Chronic Hepatitis C Activity: Correlation with Lymphadenopathy on MR  Imaging

Zhang, Xiaoming; Mitchell, Donald G.; Shi, Hongyu; Holland, George A.; Parker, Laurence; Herrine, Steven K.; Pasqualin, Denise da Cunha; Rubin, Raphael

doi:10.2214/ajr.179.2.1790417

Cited by 27 publications

(23 citation statements)

References 26 publications

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“…25 Nodal sizes were also positively correlated with viremia 19,22 and could be markers for the virological response in the treatment of chronic hepatitis C. 29,32 However, they may be correlated with serological values that would consequently become controversial. 17,22,24,29 Our study demonstrated that different parameters of nodal size led to different results and that nodal width might be superior to other parameters in terms of representing a lymph node in its reactive state. Additional studies are needed to further elucidate this phenomenon.…”

Section: Discussionmentioning

confidence: 80%

“…[16][17][18][19] Indeed, enlarged lymph nodes might be the only sonographic manifestation of significant liver disease. 10 Enlarged lymph nodes in the hepatoduodenal ligament have been reported in chronic hepatitis B 20,21 and in chronic hepatitis C, [16][17][18][19][22][23][24] with a variable incidence of 45-100%. Most studies performed before the era of hepatitis C virus (HCV) dealt with the nodal prevalence [8][9][10][11] ; studies performed after this era focused mainly on chronic hepatitis.…”

mentioning

confidence: 99%

“…Most studies performed before the era of hepatitis C virus (HCV) dealt with the nodal prevalence [8][9][10][11] ; studies performed after this era focused mainly on chronic hepatitis. [15][16][17][18][19][20][22][23][24] A few studies have included lymph nodes of healthy subjects and asymptomatic subjects with anti-HCV antibodies with normal transaminase values. 25,26 In these studies, nodal sizes and their clinical significance differed.…”

mentioning

confidence: 99%

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Enlarged lymph nodes in porta hepatis: Sonographic sign of chronic hepatitis B and C infections

Kuo

Lin

Chen

et al. 2006

J of Clinical Ultrasound

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Section: Discussionmentioning

confidence: 80%

mentioning

confidence: 99%

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confidence: 99%

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Enlarged lymph nodes in porta hepatis: Sonographic sign of chronic hepatitis B and C infections

Kuo

Lin

Chen

et al. 2006

J of Clinical Ultrasound

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“…In recent years, multiple non-invasive magnetic resonance imaging (MRI) and spectroscopy (MRS) procedures have been developed which yield a number of parameters characterizing diseased tissue. Using conventional MRI, some correlation was observed between lymph node number, size and hyperintensity, and the activity of chronic hepatitis C. 12 Another rapid MRI technique is diffusion-weighted imaging (DWI) which can be recorded in the liver within an apnea period. It measures the apparent diffusion coefficient (ADC) of water, a parameter dependent on the tissue structure.…”

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confidence: 99%

Diffusion‐weighted MR imaging of the liver of hepatitis C patients

et al. 2003

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Magnetic resonance diffusion-weighted imaging (DWI) of the liver was investigated to determine whether this method could be used to differentiate between the stages of fibrosis and inflammation for hepatitis C viral infection. DWI data were recorded for 18 hepatitis C patients and 10 control subjects using a modified pulse sequence allowing a 52 ms echo time delay. Acquisitions were performed with breath holding using five different b gradient factor values ranging between 50 and 250 s/mm(2) and in the three axes. Apparent diffusion coefficient (ADC) values were measured from a 5.7 cm(2) area in the central region of the liver. The inflammation and fibrosis grades were evaluated histologically on a biopsy sample. The mean ADC values were 2.30 +/- 1.28 x 10(-3) and 1.79 +/- 0.25 x 10(-3) mm(2)/s for hepatitis C patients and control subjects, respectively. Using our technique, no correlation could be found between the ADC values and the inflammation or fibrosis scores, indicating that tissue changes produced by hepatitis C do not appear to be quantifiable by DWI.

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“…it has been reported that the lymph node size was correlated with an index of hepatocellular injury, aST, indices of cholestasis, alP and γ-GTP, and a humoral immune reaction marker, IgM level, and was a secondary reaction of inflammation in hepatic lobules (2). regarding cHc, lyttkens et al (1) reported a positive correlation between the ln index and γ-GTP (r=0.53), and Spinetti et al (8) reported a significant correlation with ALT, though no significant correlation with liver function was noted in other reports (5,15). Thus, the correlation between lymph node size and laboratory data was inconsistent among the previous reports, and the lymph node may be observed even in healthy individuals.…”

Section: Measurement No 8 Ln (Cut-off Value 70) --------------------mentioning

confidence: 93%

Clinical significance of ultrasonographic imaging of the common hepatic arterial lymph node (No. 8 LN) in chronic liver diseases

Nakanishi

Shiraki²,

Sugimoto³

et al. 2010

Mol Med Rep

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Abstract. in chronic liver diseases, the size of the portal lymph node and the common hepatic arterial lymph node (no. 8a ln) is often altered. The objective of this study was to investigate the relationship between the pathology of chronic liver diseases and the common hepatic arterial lymph nodes using an ultrasonographic diagnostic system. The subjects included 115 patients with hepatitis c (chronic hepatitis c, 75; liver cirrhosis c, 40), 31 patients with hepatitis B (chronic hepatitis B, 17; liver cirrhosis B, 14), 16 patients with primary biliary cirrhosis (PBc), 11 patients with autoimmune hepatitis (aiH), 29 patients with alcoholic hepatitis (alc.ld) and 190 healthy adults with no abnormalities in liver function or inflammatory reactions (100 males and 90 females, age range 26-71 years, mean 49.2). The long and short axes of no. 8 ln were measured, and the value calculated by multiplying the two diameters was designated as the ln index (Fig. 1). The No. 8 LN appearance rate and LN index were significantly higher in the patients with hepatitis c, PBc and aiH than in the healthy subjects. When the ln index cut-off value was set to 50, alanine aminotransferase and aspartate aminotransferase were significantly higher in chronic hepatitis C (cHc) patients than in the healthy subjects. in addition, the LN and splenic indexes were significantly correlated in CHC patients, suggesting that the lX index is related to portal pressure increase with an elevation of sinusoidal pressure. The LN index after interferon therapy was significantly lower in complete responders than in non-responders. The no. 8 ln index may be closely related to the pathology of chronic liver diseases.

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Chronic Hepatitis C Activity: Correlation with Lymphadenopathy on MR Imaging

Abstract: MR imaging depicts perihepatic lymph nodes in most patients with chronic hepatitis C. Lymph node number, size, and hyperintensity were related to the activity of chronic hepatitis C, but the results of liver function tests were not.

Cited by 27 publications

References 26 publications

Enlarged lymph nodes in porta hepatis: Sonographic sign of chronic hepatitis B and C infections

Enlarged lymph nodes in porta hepatis: Sonographic sign of chronic hepatitis B and C infections

Diffusion‐weighted MR imaging of the liver of hepatitis C patients

Clinical significance of ultrasonographic imaging of the common hepatic arterial lymph node (No. 8 LN) in chronic liver diseases

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