Textbooks are a cornerstone in the training of medical staff and students, and they are an important source of references and reviews for these professionals. The objective of this study was to determine both the quantity and quality of chronic fatigue syndrome (CFS) information included in medical texts. After reviewing 119 medical textbooks from various medical specialties, we found that 48 (40.3%) of the medical textbooks included information on CFS. However, among the 129,527 total pages within these medical textbooks, the CFS content was presented on only 116.3 (.090%) pages. Other illnesses that are less prevalent, such as Multiple Sclerosis and Lyme disease, were more frequently represented in medical textbooks. These findings suggest that the topic of CFS is under-reported in published medical textbooks.