Chronic exposure to cobalt compounds — an in vivo study

Gluhcheva, Yordanka; Atanasov, Vasil; Ivanova, Juliana; Pavlova, Ekaterina

doi:10.2478/s11535-014-0334-x

Cited by 3 publications

(2 citation statements)

References 16 publications

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“…Co (specially CoCl2) has been associated with hepatocellular injuries and -ns [ 16 ], even though the literature is scarce for this element. For human and animal populations, diet (including drinking water) is the main source of Co [ 25 ]. In hedgehogs, the only mean value of Co found in the literature was 0.40 ± 0.04 mg/kg dw [ 6 ], which is exactly the same mean value we found in hedgehogs with biliary hyperplasia (0.40 ± 0.42 mg/kg dw), but higher than the one we obtained for the whole group of hedgehogs (0.27 ± 0.28 mg/kg dw).…”

Section: Discussionmentioning

confidence: 99%

High Levels of Heavy Metal(loid)s Related to Biliary Hyperplasia in Hedgehogs (Erinaceus europaeus)

Baptista

Seixas

Gonzalo-Orden

et al. 2023

Animals

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Heavy metal(loid) pollution of ecosystems is a current One Health problem. The liver is one of the most affected organs in cases of acute or chronic exposure to abnormal amounts of these substances, inducing histopathologic lesions. In order to assess the influence of heavy metal(loids), forty-five European hedgehogs (Erinaceus europaeus) were submitted to necropsy, and liver samples were collected for a routine histopathology exam and metal(loid)s determination (As, Cd, Co, Cr, Cu and Pb) by ICP-MS. Age was estimated during the necropsy exam. Biliary hyperplasia was the most frequent lesion observed (16/45; 35.56%). No statistically significant associations were found between biliary hyperplasia and age or sex. Metal(loid)s’ concentrations were higher in animals with biliary hyperplasia (except for As). There was a statistically significant difference for both Cd and Co. For As, Cd and Co, cubs and juveniles animals showed significantly lower concentrations than elder individuals. Only for Pb were significant differences found between females and males. As described in the literature, exposure to metal(loid)s may be a cause of biliary hyperplasia, although further research (including the use of biochemical methods) is needed to support these results. To the authors’ knowledge, this is the first report of this association in hedgehogs.

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Section: Discussionmentioning

confidence: 99%

High Levels of Heavy Metal(loid)s Related to Biliary Hyperplasia in Hedgehogs (Erinaceus europaeus)

Baptista

Seixas

Gonzalo-Orden

et al. 2023

Animals

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“…According to studies on laboratory animals exposed to metal ions over an extended period of time, these ions build up in organs such the kidney, liver, spleen, heart, stomach, intestines, muscle, brain, and testes. Additionally, whole blood, serum, and urine all have higher concentrations of Co [19]. Although absorption varies depending on the species, water-soluble cobalt compounds absorb more than non-water-soluble forms [20].…”

Section: Introductionmentioning

confidence: 99%

Acute Toxicity of Aluminum, Cobalt, and Lithium Chlorides in Albino wistar Mice: Determination of Lethal Doses

Taha,

Mohammed,

Mohammed

2024

IJDNE

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Chlorides are considered one of the dangerous pollutants that pose a threat to human and animal health. The study aims to determine the acute lethal doses (LD50) of aluminum, cobalt, and lithium chlorides in Albino wistar mice. Albino wistar mice were divided into four groups with the mice were randomly divided into 4 groups, 8 mice for experimental group and 6 mice for control group. Short tests were conducted to determine the acute lethal dose of the metals under study. Over 168 hours, mice were exposed to four different concentrations of (AlCl2) metal in concentrations of 40, 50, 60 and 70 mg/kg per liter of water, where 1 liter of water was placed in each bottle, while the second group was exposed to cobalt chloride (CoCl2) in concentrations 75, 100, 125 and 150 mg/kg per liter of water, where 1 liter of water was placed in each bottle. As well as, the third group, it was exposed to (LiCl2) at concentrations 75, 100, 125 and 150 mg/kg per liter of water, while the fourth group included the control group. 1 liter of water was placed in each bottle and it was given orally. LC50 was calculated by use Finney's probit analysis method where LC50 it is abbreviation "lethal concentration 50%" or "intermediate lethal concentration". It is the concentration of a material (in the water) which it killed a half the members of populations after a specific during of exposed to toxic metal. This value is so importance in toxicology because it gives an indicated of materials poisoning. The LC50 is inverse proportionate to toxicity. The current study concluded the dose that killed 50% of the Albino wistar mice was 50mg/kg of AlCl2, 100mg/kg of CoCl2, while it was 125mg/kg of lithium chloride. Long-term use of greater doses of chlorides can have varying degrees of negative impact on various organs in mice. This study provides context for a more thorough investigation of the toxicity of chlorides compounds on humans, which may be significant for public health.

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Heavy metals and metalloids in wild boars (Sus Scrofa) – a silent but serious public health hazard

Jota Baptista,

Seixas,

Gonzalo-Orden

et al. 2023

Vet Res Commun

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Chronic exposure to cobalt compounds — an in vivo study

Cited by 3 publications

References 16 publications

High Levels of Heavy Metal(loid)s Related to Biliary Hyperplasia in Hedgehogs (Erinaceus europaeus)

High Levels of Heavy Metal(loid)s Related to Biliary Hyperplasia in Hedgehogs (Erinaceus europaeus)

Acute Toxicity of Aluminum, Cobalt, and Lithium Chlorides in Albino wistar Mice: Determination of Lethal Doses

Heavy metals and metalloids in wild boars (Sus Scrofa) – a silent but serious public health hazard

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