Chronic ethanol intake leads to structural and molecular alterations in the rat endometrium

Martinez, Marcelo; Milton, Flora Aparecida; Pinheiro, Patrícia Fernanda Felipe; Almeida-Francia, Camila Contin Diniz de; Cagnon, Valéria Helena Alves; Tirapelli, Luís Fernando; Padovani, Carlos Roberto; Chuffa, Luiz Gustavo de Almeida; Martinez, Francisco Eduardo

doi:10.1016/j.alcohol.2016.02.002

Cited by 5 publications

(8 citation statements)

References 24 publications

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“…This finding is consistent with a study conducted by J Lyngsø et al in which they also identified shorter cycles among women abstaining from alcohol, associating these alterations with the fact that alcohol exposure can produce alterations in the hormonal system [ 47 ]. In addition, studies in rats have associated chronic alcohol consumption with endometrial changes and reproductive disorders [ 48 ].…”

Section: Discussionmentioning

confidence: 99%

Relationship between Diet, Menstrual Pain and other Menstrual Characteristics among Spanish Students

et al. 2020

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This study sought to describe and compare adherence to the Mediterranean diet and consumption of local foods from the Huelva region among Spanish university women in relation to menstrual pain and other menstrual characteristics. This cross-sectional study included 311 health science students. The study variables were sociodemographic and gynecologic characteristics, adherence to the Mediterranean diet using the KIDMED questionnaire, alcohol consumption (SDU) and consumption of local food. A descriptive bivariate analysis and multiple binary regression were performed for menstrual pain. Up to 55.3% of participants had moderate adherence to the Mediterranean diet and only 29.6% had high adherence. Women with low adherence had longer menstrual cycles (p < 0.01). Eating less than two pieces of fruit per day (OR = 3.574; 95%CI = 1.474–8.665; p < 0.05) and eating pulses more than one day a week (OR = 2.320; 95%CI = 1.006–5.348) raised the probability of suffering menstrual pain. A positive correlation between SDU and cycle length was identified (r = 0.119, p = 0.038), and menstrual bleeding was lower in women who consumed olive oil daily (p = 0.044). In conclusion, the Mediterranean diet, alcohol consumption and consuming typical foods from southern Spain appear to influence cycle length, menstrual flow and menstrual pain. Further research is necessary to confirm and expand these findings.

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Section: Discussionmentioning

confidence: 99%

Relationship between Diet, Menstrual Pain and other Menstrual Characteristics among Spanish Students

et al. 2020

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“…We found alterations in the female and male reproductive organs in the high drinkers' group. Studies noticed an irregularity in the estrous cycle, reduction of LH and FSH, follicular atresia, and damage in uterine endometrial cells in drinkers, with effects related to the dose consumed (Chuffa et al 2009, Martinez et al 2016. Acetaldehyde and oxidative stress increase and impairs to HPG/HPA axes are mechanisms that change reproductive hormones balance and, consequently, uterine and ovarian tissues (Buthet et al 2003, Rachdaoui & Sarkar 2017.…”

Section: Discussionmentioning

confidence: 99%

“…CC-BY-NC-ND 4.0 International license made available under a (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is The copyright holder for this preprint this version posted July 18, 2021. ; https://doi.org/10.1101/2021.07.16.452713 doi: bioRxiv preprint a voluntary model of ethanol exposure, UCh rats, avoiding the stress associated with forced feeding and providing knowledge about the effects of voluntary ethanol consumption as observed in society (Gapp et al 2014, Martinez et al 2016).…”

Section: Animals and Experimental Designmentioning

confidence: 99%

“…The animals were housed in polypropylene cages (32 cm × 40 cm × 18 cm) and maintained under controlled conditions (25 ± 1 °C, humidity 55 ± 5 %, and light from 6 to 18 h) with access to commercial feed and water ad libitum. In this study, we employed a voluntary model of ethanol exposure, UCh rats, avoiding the stress associated with forced feeding and providing knowledge about the effects of voluntary ethanol consumption as observed in society (Gapp et al 2014, Martinez et al 2016).…”

Section: Animals and Experimental Designmentioning

confidence: 99%

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The low and high postpubertal ethanol use: long-term effects on drinkers’ reproductive parameters and ethanol-naive offspring development

Fioravante

Godoi

Camargo

et al. 2021

Preprint

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The relationship between adolescent ethanol uses and its impacts throughout life is not conclusive. Thus, we evaluated if the low and high consumption of ethanol during the postpuberty period interferes with reproduction in adulthood, the ethanol-naive offspring development and if there are dose-related effects. Females and males rats were divided into three groups: low drinker (L), with UChA rats fed with ethanol ad libitum drinking < 1.9 g / kg / day, high drinker (H), with UChB rats fed with ethanol ad libitum drinking from 2 to 5 g / kg / day, and control (C), with rats without access to ethanol. The L and H groups were exposed to ethanol 10% (v/ v) from 65 to 80 days, with withdrawal after this period. The study was conducted in two phases. The retrospective analysis (1st phase) verified the consumption of ethanol between sexes, the litter size, and the sex ratio of offspring. The gestational and reproductive parameters of parents and the development of pups were analyzed in the 2nd phase. We observed a higher consumption of ethanol in females and a reduced litter size in both drinkers groups. Body weight gain and gestational feed consumption were lower in L and H. The offspring body weight was also lower associated with alteration in landmarks of physical development. The high postpubertal ethanol use accents the impacts on consumers and offspring. The paternal and maternal reproductive organs weight was altered in group H, with an increase in morphologically abnormal sperm. We conclude that low and high post-pubertal alcohol consumption impairs reproductive parameters, even after withdrawal with long-term effects. Ethanol-naive offspring are also harmed, with effects associated with the dose of ethanol.

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“…The animals were housed in polypropylene cages (32 cm × 40 cm × 18 cm) and maintained under controlled conditions (25 ± 1°C, humidity 55 ± 5%, and light from 6 to 18 h) with access to commercial feed and water ad libitum . We employed a voluntary model for ethanol exposure, UCh rat strain, avoiding the stress associated with forced feeding and providing knowledge about the effects of voluntary ethanol consumption as observed in society ( Gapp et al 2014 , Martinez et al 2016 ).…”

Section: Methodsmentioning

confidence: 99%

Low and high postpubertal ethanol use: damage on adulthood reproduction and offspring

Fioravante

Godoi

Camargo

et al. 2022

Reproduction and Fertility

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The relationship between adolescent ethanol uses and its impacts throughout life are not conclusive. Thus, we evaluated if the low and high consumption of ethanol at postpuberty interferes with the reproduction, ethanol-naive offspring and if the effects are dose-related. Female and male rats were divided into three groups: low drinker (L), high drinker (H), and control (C). The L and H groups were exposed to ethanol to 10% from 65 to 80 days with withdrawal after this period. The ethanol consumed by low drinkers was 1.41 ± 0.21 g/ kg / day and high drinkers 4.59 ± 0.45 g/ kg / day. The study was conducted in two phases. The 1st phase verified the reproductive capacity in adulthood on generations (litter size and sex ratio). Data were collected over ten years. The 2nd phase analyzed the parent reproductive parameters (body weight, reproductive organ weight, sperm parameters and estrous cycle) and the pup development. We observed a reduced litter size in both drinker groups. Gestational body weight gain and feed consumption were lower in L and H. We observed an alteration in reproductive organs weight in both sexes of H. Females presented a longer estrous cycle duration. Males presented an increase in abnormal sperm, a decrease in sperm count and accelerated transit time. The ethanol-naïve offspring development was also impaired. We conclude that low and high postpubertal alcohol use impairs long-term reproductive parameters, even after alcohol withdrawal. There is also impaired ethanol-naive offspring. Besides, the effects are dose-related.

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Chronic ethanol intake leads to structural and molecular alterations in the rat endometrium

Cited by 5 publications

References 24 publications

Relationship between Diet, Menstrual Pain and other Menstrual Characteristics among Spanish Students

Relationship between Diet, Menstrual Pain and other Menstrual Characteristics among Spanish Students

The low and high postpubertal ethanol use: long-term effects on drinkers’ reproductive parameters and ethanol-naive offspring development

Low and high postpubertal ethanol use: damage on adulthood reproduction and offspring

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