Chronic ethanol intake and reduction of lung tumours from urethane in strain a mice

Modulation by Ethanol of Cigarette Smoke Clastogenicity in Cells of Adult Mice and of Transplacentally Exposed Fetuses

“…In agreement with the above hypothesis, CS decreased acetaldehyde concentration after EtOH administration, while EtOH increased the rate of elimination of cotinine [34]. In mice, EtOH inhibited the pulmonary tumorigenicity of urethane [35], and disulfiram inhibited the clastogenicity of this CS constituent, which like EtOH is metabolized via the CYP2E1 pathway [36]. These findings support the hypothesis that EtOH may alter the metabolism of clastogenic MCS constituents in the lower respiratory tract.…”

Modulation by Ethanol of Cigarette Smoke Clastogenicity in Cells of Adult Mice and of Transplacentally Exposed Fetuses

“…In agreement with the above hypothesis, CS decreased acetaldehyde concentration after EtOH administration, while EtOH increased the rate of elimination of cotinine [34]. In mice, EtOH inhibited the pulmonary tumorigenicity of urethane [35], and disulfiram inhibited the clastogenicity of this CS constituent, which like EtOH is metabolized via the CYP2E1 pathway [36]. These findings support the hypothesis that EtOH may alter the metabolism of clastogenic MCS constituents in the lower respiratory tract.…”

Inhalation of an Ethanol-Based Zileuton Formulation Provides a Reduction of Pulmonary Adenomas in the A/J Mouse Model

“…Conversely, in studies conducted by Dahl et al, involving a potential chemopreventive agent dissolved in ethanol, a statistically significant reduction in the numbers of tumors induced by several carcinogens, including B(a)P, was observed; however, as with the current study, a statistically significant reduction in tumor incidence was also observed for groups exposed to vehicle only (28). In addition, studies by Stoewsand et al and Kristianssen et al have shown potential protective effects of ethanol on ethyl carbamate (urethane) induced tumorigenesis in liver and lung (29,30). Batkin and Tabrah specifically investigated the effect of ethanol vapor administered via aerosol on Lewis lung carcinoma (31).…”

The Area under the Plasma Concentration Curve (AUC) of Urethane in Mice and the Influence of Concomitant Administration of Ethanol

“…A Author for correspondence: Eva Kristiansen, Institute of Toxicology, National Food Agency, 19, M o r k h~j Bygade, DK-2860 Soborg, Denmark (fax +45 39 66 01 00). dose-dependent inhibitory action of concomitant ethanol intake upon the development of lung adenomas in mice given urethane was found (Kristiansen et al 1990). In a study where ethanol was administered as bolus, Altmann et al (1991) found no influence on the development of lung adenomas in mice dosed urethane.…”

“…Two urethane doses were used: 37.5 mg/kg b.wt. corresponding to the lowest dose previously used and demonstrated to induce tumours (Kristiansen et al 1990), and 75 mg/kg b.wt. corresponding to a dose reported to exceed saturation of the metabolism of urethane in mice (Nomeir et al 1989).…”

Modulation by Ethanol of Cigarette Smoke Clastogenicity in Cells of Adult Mice and of Transplacentally Exposed Fetuses

“…In agreement with the above hypothesis, CS decreased acetaldehyde concentration after EtOH administration, while EtOH increased the rate of elimination of cotinine [34]. In mice, EtOH inhibited the pulmonary tumorigenicity of urethane [35], and disulfiram inhibited the clastogenicity of this CS constituent, which like EtOH is metabolized via the CYP2E1 pathway [36]. These findings support the hypothesis that EtOH may alter the metabolism of clastogenic MCS constituents in the lower respiratory tract.…”

Inhalation of an Ethanol-Based Zileuton Formulation Provides a Reduction of Pulmonary Adenomas in the A/J Mouse Model

“…Conversely, in studies conducted by Dahl et al, involving a potential chemopreventive agent dissolved in ethanol, a statistically significant reduction in the numbers of tumors induced by several carcinogens, including B(a)P, was observed; however, as with the current study, a statistically significant reduction in tumor incidence was also observed for groups exposed to vehicle only (28). In addition, studies by Stoewsand et al and Kristianssen et al have shown potential protective effects of ethanol on ethyl carbamate (urethane) induced tumorigenesis in liver and lung (29,30). Batkin and Tabrah specifically investigated the effect of ethanol vapor administered via aerosol on Lewis lung carcinoma (31).…”

The Area under the Plasma Concentration Curve (AUC) of Urethane in Mice and the Influence of Concomitant Administration of Ethanol

“…A Author for correspondence: Eva Kristiansen, Institute of Toxicology, National Food Agency, 19, M o r k h~j Bygade, DK-2860 Soborg, Denmark (fax +45 39 66 01 00). dose-dependent inhibitory action of concomitant ethanol intake upon the development of lung adenomas in mice given urethane was found (Kristiansen et al 1990). In a study where ethanol was administered as bolus, Altmann et al (1991) found no influence on the development of lung adenomas in mice dosed urethane.…”

“…Two urethane doses were used: 37.5 mg/kg b.wt. corresponding to the lowest dose previously used and demonstrated to induce tumours (Kristiansen et al 1990), and 75 mg/kg b.wt. corresponding to a dose reported to exceed saturation of the metabolism of urethane in mice (Nomeir et al 1989).…”

Modulation by Ethanol of Cigarette Smoke Clastogenicity in Cells of Adult Mice and of Transplacentally Exposed Fetuses

“…In agreement with the above hypothesis, CS decreased acetaldehyde concentration after EtOH administration, while EtOH increased the rate of elimination of cotinine [34]. In mice, EtOH inhibited the pulmonary tumorigenicity of urethane [35], and disulfiram inhibited the clastogenicity of this CS constituent, which like EtOH is metabolized via the CYP2E1 pathway [36]. These findings support the hypothesis that EtOH may alter the metabolism of clastogenic MCS constituents in the lower respiratory tract.…”

Inhalation of an Ethanol-Based Zileuton Formulation Provides a Reduction of Pulmonary Adenomas in the A/J Mouse Model

“…Conversely, in studies conducted by Dahl et al, involving a potential chemopreventive agent dissolved in ethanol, a statistically significant reduction in the numbers of tumors induced by several carcinogens, including B(a)P, was observed; however, as with the current study, a statistically significant reduction in tumor incidence was also observed for groups exposed to vehicle only (28). In addition, studies by Stoewsand et al and Kristianssen et al have shown potential protective effects of ethanol on ethyl carbamate (urethane) induced tumorigenesis in liver and lung (29,30). Batkin and Tabrah specifically investigated the effect of ethanol vapor administered via aerosol on Lewis lung carcinoma (31).…”

The Area under the Plasma Concentration Curve (AUC) of Urethane in Mice and the Influence of Concomitant Administration of Ethanol

“…A Author for correspondence: Eva Kristiansen, Institute of Toxicology, National Food Agency, 19, M o r k h~j Bygade, DK-2860 Soborg, Denmark (fax +45 39 66 01 00). dose-dependent inhibitory action of concomitant ethanol intake upon the development of lung adenomas in mice given urethane was found (Kristiansen et al 1990). In a study where ethanol was administered as bolus, Altmann et al (1991) found no influence on the development of lung adenomas in mice dosed urethane.…”

“…Two urethane doses were used: 37.5 mg/kg b.wt. corresponding to the lowest dose previously used and demonstrated to induce tumours (Kristiansen et al 1990), and 75 mg/kg b.wt. corresponding to a dose reported to exceed saturation of the metabolism of urethane in mice (Nomeir et al 1989).…”