Chronic eosinophilic pneumonia after radiation therapy for breast cancer

Cottin, Vincent; Frognier, R.; Monnot, H.; Levy, Alexander N.; Devuyst, Paul; Jf, Cordier

doi:10.1183/09031936.03.00071303

Cited by 73 publications

(45 citation statements)

References 20 publications

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“…4 Eosinophilia identification is important for diagnosis and can be determined by BAL Ն 25%. 1,4,5,8 This proves the eosinophilic nature of the lung injury. Increased eosinophilia in BAL is secondary to a suppressed Fas-mediated apoptosis, thus prolonging the survival of those apoptotic cells.…”

Section: Case Reportmentioning

confidence: 68%

“…10 As part of the treatment for breast cancer, radiation therapy has been shown to lead to CEP, especially in those who have underlying allergies such as asthma or atopic manifestations. 1,11 Usually the areas that are irradiated are the ones that may develop CEP. 1 High-resolution CT is highly sensitive in the detection of lung injury post-radiation.…”

Section: Case Reportmentioning

confidence: 99%

“…1,11 Usually the areas that are irradiated are the ones that may develop CEP. 1 High-resolution CT is highly sensitive in the detection of lung injury post-radiation. 10 Radiation therapy may predispose for CEP; however, a trigger such as an environmental exposure, drugs, and Aspergillus is usually needed.…”

Section: Case Reportmentioning

confidence: 99%

“…10 Radiation therapy may predispose for CEP; however, a trigger such as an environmental exposure, drugs, and Aspergillus is usually needed. 1 The proposed mechanism is priming followed by an antigenic stimulation. 1,12 The patient presented is a runner, thus putting her at high risk of exposure to environmental allergens.…”

Section: Case Reportmentioning

confidence: 99%

“…1 Onset is insidious, with symptoms lasting up to 2-4 weeks. It is usually idiopathic; however, it has been associated with drugs, allergy shots, parasites, irradiation for breast cancer, and rheumatoid arthritis.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Chronic Eosinophilic Pneumonia in a Breast Cancer Patient Post-Radiation Therapy: A Case Report

Chaaban

Salloum

2013

Respir Care

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Section: Case Reportmentioning

confidence: 68%

Section: Case Reportmentioning

confidence: 99%

Section: Case Reportmentioning

confidence: 99%

Section: Case Reportmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Chronic Eosinophilic Pneumonia in a Breast Cancer Patient Post-Radiation Therapy: A Case Report

Chaaban

Salloum

2013

Respir Care

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Respiratory Complications

Shannon

Eapen

Jiménez

et al. 2017

Holland‐Frei Cancer Medicine

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Overview The respiratory system is particularly susceptible to complications of cancer and cancer therapy. This vulnerability arises from the stringent architectural requirements for gas exchange, the continuous exposure of the respiratory tract to the external environment, and the severe symptoms that can accompany respiratory compromise. Gas exchange requires patent airways, an effective musculoskeletal ventilatory pump, a thin alveolocapillary membrane, and adequate blood flow through the pulmonary circulation. In cancer patients, primary and metastatic tumors of the chest compromise major airways; pleural effusions externally compress the lungs and impair diaphragmatic function; direct, hematogenous, or lymphangitic spread of tumor replaces functioning lung parenchyma; resectional surgery reduces parenchymal volume; nonresectional surgery can transiently impair lung function; radiotherapy, chemotherapy, stem cell therapy, and infection injure the vulnerable alveolocapillary membrane; tumors directly or indirectly compromise the musculoskeletal pump; and venous thromboembolism (VTE) and pulmonary vasculopathy obstruct pulmonary blood flow. The normal respiratory system contains considerable physiologic reserve, such that surgical loss of one lung is generally well tolerated. However, in cancer patients, insults to multiple components of the respiratory system may result in progressive loss of physiologic reserve and increasing dyspnea. Dyspnea, cough, wheezing, stridor, chest pain, and hemoptysis are common symptoms in the cancer setting that lead to pulmonary consultation. In this chapter, we will discuss the pathophysiology, diagnosis, and management of the major respiratory complications of cancer and its therapy. We begin with the direct effects of cancer and cancer therapies on the lungs, review major indirect effects of cancer on the lungs, and end with respiratory failure in the cancer patient.

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Respiratory Complications

Shannon¹,

Eapen²,

Jiménez³

et al. 2022

Holland‐Frei Cancer Medicine

View full text Add to dashboard Cite

Overview The respiratory system is particularly susceptible to complications of cancer and cancer therapy. This vulnerability arises from the stringent architectural requirements for gas exchange, the continuous exposure of the respiratory tract to the external environment, and the severe symptoms that can accompany respiratory compromise. Gas exchange requires patent airways, an effective musculoskeletal ventilatory pump, a thin alveolocapillary membrane, and adequate blood flow through the pulmonary circulation. In cancer patients, primary and metastatic tumors of the chest compromise major airways; pleural effusions externally compress the lungs and impair diaphragmatic function; direct, hematogenous or lymphangitic spread of tumor replaces functioning lung parenchyma; resectional surgery reduces parenchymal volume; nonresectional surgery can transiently impair lung function; radiotherapy, chemotherapy, stem cell therapy, and infection injure the vulnerable alveolocapillary membrane; tumors directly or indirectly compromise the musculoskeletal pump; venous thromboembolism and pulmonary vasculopathy obstruct pulmonary blood flow. The normal respiratory system contains considerable physiologic reserve, such that surgical loss of one lung is generally well tolerated. However, in cancer patients, insults to multiple components of the respiratory system may result in progressive loss of physiologic reserve and increasing dyspnea. Dyspnea, cough, wheezing, stridor, chest pain, and hemoptysis are common symptoms in the cancer setting that lead to pulmonary consultation. In this article, we will discuss the pathophysiology, diagnosis, and management of the major respiratory complications of cancer and its therapy. We begin with the direct effects of cancer and cancer therapies on the lungs, review major indirect effects of cancer on the lungs, and end with respiratory failure in the cancer patient.

show abstract

Chronic eosinophilic pneumonia after radiation therapy for breast cancer

Cited by 73 publications

References 20 publications

Chronic Eosinophilic Pneumonia in a Breast Cancer Patient Post-Radiation Therapy: A Case Report

Chronic Eosinophilic Pneumonia in a Breast Cancer Patient Post-Radiation Therapy: A Case Report

Respiratory Complications

Respiratory Complications

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