Chronic disruption of circadian rhythms impairs hippocampal memory in the rat

Craig, Laura A.; McDonald, Robert J.

doi:10.1016/j.brainresbull.2008.02.013

Cited by 86 publications

(72 citation statements)

References 52 publications

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“…While the direct sleep-wake comparison was not significant in the short feedback condition, there was a significant 10% improvement after sleep (P = 0.03), while the matched Wake group showed only a nonsignificant 3% improvement (P = 0.22). In addition, there was a trend toward a correlation between initial performance and subsequent improvement in the Sleep group (r = À0.50, P = 0.08), but no hint of a correlation in the Wake group (r = 0.05, P = 0.85), further supporting the possibility that sleep leads to improved performance on the WPT in short feedback condition.Some evidence, mainly from animal studies, has suggested a circadian influence on synaptic plasticity, particularly in the hippocampus (Craig and McDonald 2008;Ruby et al 2008). Thus, as with any study comparing memory consolidation over a period of wakefulness vs. sleep, we cannot exclude the possibility of additional circadian effects on our results.…”

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confidence: 85%

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Sleep enhances category learning

Djonlagic¹,

Rosenfeld²,

Shohamy³

et al. 2009

Learn. Mem.

102

100

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The ability to categorize objects and events in the world around us is a fundamental and critical aspect of human learning. We trained healthy adults on a probabilistic category-learning task in two different training modes. The aim of this study was to see whether either form of probabilistic category learning (feedback or observational) undergoes subsequent enhancement during sleep. Our results suggest that after training, a good night of sleep can lead to improved performance the following day on such tasks.[Supplemental material is available online at http://www.learnmem.org.]From infancy, humans categorize objects and events they encounter. In our daily lives, this category learning enables us to extract rules and patterns from our varied experiences, and to formulate new responses and inferences to familiar objects and events, thereby facilitating decision-making and problem-solving processes .While there is now considerable understanding of the early stages of category learning, relatively little is known about how such learning evolves over time. A growing literature shows that post-training sleep plays an important role in long-term memory consolidation and enhancement (Stickgold 2005;Diekelmann et al. 2009). The most compelling evidence thus far comes from simple perceptual and motor procedural learning, such as fingertapping sequences and visual discrimination tasks (Karni et al. 1994;Gais et al. 2000;Stickgold et al. 2000;Walker et al. 2002;Huber et al. 2004). Much less is understood about the role of sleep in the learning of explicit episodic memory tasks, and even less for more complex memory tasks, such as probabilistic category learning (Smith and Smith 2003;Wagner et al. 2004;Ellenbogen et al. 2007).There are two basic patterns by which categorizations can be learned: We can simply observe stimuli and their outcomes (observational learning), or we can be shown stimuli and then asked to predict outcomes, only then receiving feedback on the accuracy of our response (feedback learning). The Weather Prediction Task (WPT) was initially described by Knowlton et al. (1994) and has been extensively studied as a paradigm for such category learning (Knowlton et al. 1994;Gluck et al. 2002;Meeter et al. 2008).Studies have shown that the WPT activates different memory systems depending on how the task is learned and on the extent of training. Neuroimaging studies have shown that subjects who simply observe stimuli and their outcomes activate learning and memory systems that are supported by the medial temporal lobe (MTL) and prefrontal cortex (observational learning, Fig. 1, top). On the other hand, subjects who must predict outcomes for each stimulus and only then receive feedback on their accuracy (feedback learning, Fig. 1, bottom), initially activate the MTL, but as training continues shift this activation to the striatum, which is known to be involved with habit and skill-learning behaviors (Poldrack et al. 2001).Evidence from studies with patient populations supports this conclusion. Patients in whom b...

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confidence: 85%

“…Some evidence, mainly from animal studies, has suggested a circadian influence on synaptic plasticity, particularly in the hippocampus (Craig and McDonald 2008;Ruby et al 2008). Thus, as with any study comparing memory consolidation over a period of wakefulness vs. sleep, we cannot exclude the possibility of additional circadian effects on our results.…”

mentioning

confidence: 85%

Sleep enhances category learning

Djonlagic¹,

Rosenfeld²,

Shohamy³

et al. 2009

Learn. Mem.

102

100

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“…As the leading symptom of AD is the memory deficit [28], molecules that influence memory formation might have a pathogenic role. In connection with its role in circadian regulation [15] AVP might be such a molecule. Indeed, administration of AVP receptor antagonists resulted in memory impairment both in mice [3] and in rats [39].…”

Section: Introductionmentioning

confidence: 99%

Increase in Alzheimer's related markers preceeds memory disturbances: Studies in vasopressin-deficient Brattleboro rat

Várga

Klausz

Domokos

et al. 2014

Brain Research Bulletin

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Alzheimer's disease (AD) is the most common form of dementia in the elderly. For more effective therapy early diagnostic markers could be beneficial. Therefore we compared one year old rats with adults and examined if changes in possible brain markers of AD preceeded memory decline. We also tested if vasopressin-deficient animals were useful model of AD as vasopressin has well known positive effect on memory and AD patient has decreased vasopressin production.We compared adult (3 month) and old (12 month), normal and vasopressin-deficient Brattleboro rats. To receive a comprehensive picture about their memory we examined their social discrimination, object discrimination and conditioned learning abilities (shuttle box).Amyloid precursor protein (APP), mitogen-activated protein kinase 1 (MAPK1), β-actin and tryptophan 2,3-dioxygenase 2 (TDO2) mRNA levels was measured by quantitative PCR.There was no difference between the memory of adult and aged groups. The vasopressin-deficient rats at both ages showed a weaker performance in the course of social and object discrimination tests and a higher escape failure during the shuttle box experiment. The brain marker mRNAs of the elder animals were higher than the levels of the adults, but the absence of vasopressin had no influence on them.Thus, the one year old rats showed elevated levels of AD-related markers, but memory deficits were observable only in vasopressin deficient animals. Vasopressin does not seem to have pathogenic role in AD. Changes in the studied markers might predict later symptoms, although further studies are required for confirmation.

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“…This has been demonstrated in many [17,[21][22][23][24], but not all [22,23], disruption and memory paradigms. Moreover, arrhythmic Siberian hamsters show deficits in long-term object recognition and spatial learning [25,26].…”

Section: Introductionmentioning

confidence: 88%

Circadian waveform bifurcation, but not phase-shifting, leaves cued fear memory intact

Harrison

Carmack

Block

et al. 2017

Physiology & Behavior

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• The circadian system was experimentally bifurcated into two days and nights per 24 h.• Pavlovian fear conditioning was used to quantify acquisition and retrieval of memory.• Retrieval of cued fear remained intact in bifurcated, but not phase-shifted, mice. a b s t r a c t a r t i c l e i n f o In mammals, memory acquisition and retrieval can be affected by time of day, as well as by manipulations of the light/dark cycle. Under bifurcation, a manipulation of circadian waveform, two subjective days and nights are experimentally induced in rodents. We examined the effect of bifurcation on Pavlovian fear conditioning, a prominent model of learning and memory. Here we demonstrate that bifurcation of the circadian waveform produces a small deficit in acquisition, but not on retrieval of fear memory. In contrast, repeated phase-shifting in a simulated jet-lag protocol impairs retrieval of memory for cued fear. The results have implications for those attempting to adjust to shift-work or other challenging schedules.

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Chronic disruption of circadian rhythms impairs hippocampal memory in the rat

Cited by 86 publications

References 52 publications

Sleep enhances category learning

Sleep enhances category learning

Increase in Alzheimer's related markers preceeds memory disturbances: Studies in vasopressin-deficient Brattleboro rat

Circadian waveform bifurcation, but not phase-shifting, leaves cued fear memory intact

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