Chronic Cystoisospora belli infection in an HIV/AIDS patient treated at the specialized assistance service in Porto Velho County - Rondônia.

Batista, Flávia Serrano; Miranda, Laís de Souza; Silva, Márcia Benedita de Oliveira; Taborda, Roger Lafontaine Mesquita; Soares, Maiara Cristina F.; Matos, Najla Benevides

doi:10.1590/0037-8682-0204-2018

Cited by 5 publications

(3 citation statements)

References 9 publications

(7 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Cystoisospora belli chronicity could be related to infection persistence possibly associated with the reactivation of the tissue cysts formed by the parasite in extra-intestinal organs or in the lamina propria of the intestine 3 . Cystoisosporiasis recurrences are increasingly observed in patients living with HIV/AIDS, particularly in those who do not respond properly to the treatment 20 . The standard treatment for C. belli infection is oral trimethoprim-sulfamethoxazole for 7 to 10 days in immunocompetent patients; however, immunosuppressed patients usually need longer treatment schedules or high doses, as well as maintenance therapy with cotrimoxazole to prevent relapses, which occur in nearly 50% of patients following discontinuation of initial therapy 21 .…”

Section: Discussionmentioning

confidence: 99%

Chronic Cystoisospora belli infection in a Colombian patient living with HIV and poor adherence to highly active antiretroviral therapy

et al. 2021

View full text Add to dashboard Cite

Cystoisospora belli is an intestinal Apicomplexan parasite associated with diarrheal illness and disseminated infections in humans, mainly immunocompromised individuals such as those living with the human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome (AIDS). An irregular administration of highly active antiretroviral therapy (HAART) in HIV patients may increase the risk of opportunistic infections like cystoisosporiasis.We describe here a case of C. belli infection in a Colombian HIV patient with chronic gastrointestinal syndrome and poor adherence to HAART. His clinical and parasitological cure was achieved with trimethoprim-sulfamethoxazole treatment. Although a reduction in the number of C. belli cases has been observed since the use of HAART, this parasite still has to be considered as a differential diagnosis of diarrheal disease in HIV/AIDS patients.Effective interventions enhancing adherence to HAART should be included in HIV patient care programs.

show abstract

Section: Discussionmentioning

confidence: 99%

Chronic Cystoisospora belli infection in a Colombian patient living with HIV and poor adherence to highly active antiretroviral therapy

et al. 2021

View full text Add to dashboard Cite

show abstract

“…The prevalence of opportunistic parasitosis in PLWHA has decreased considerably [9][10][11]. Isospora belli infection in particular is one of the least frequently encountered [2,12].…”

Section: Discussionmentioning

confidence: 99%

Diagnostic and Therapeutic Difficulties of Chronic Diarrhea with <i>Cystoisospora belli</i> Inaugural Infection by the HIV at the NTHC-HKM of Cotonou: Literature Review

Kouanou¹,

Tovè²,

Anthelme³

et al. 2021

IJIDT

View full text Add to dashboard Cite

Isosporosis is an opportunistic parasitosis caused by Cystoisospora belli. It was more or less frequently found during HIV immunodepression. Its prevalence has considerably decreased since the democratization of antiretroviral treatments and the implementation of a strategy of systematic global management of People Living with HIV (PLWH) and opportunistic infections. We report the case of a 49-year-old PLHIV patient discovered during the exploration of recurrent diarrhea. This diarrhea was found to be due to Cystoisospora belli. The patient was allergic to cotrimoxazole and was therefore initially treated with ciprofloxacin and tinidazole with poor evolution. The other treatments selected are limited by the lack of access to drugs, both geographically and financially. In view of the persistence of the clinical picture and the continuous presence of the parasite in the stools, several hypotheses have been put forward. That of an under-dosage of the molecule used, of a lack of therapeutic compliance, or of the resistance of the germ to the prescribed molecule. Although the coproculture and antibiogram revealed the sensitivity of the germ to the Ciprofloxacin already prescribed, and to the Cotrimoxazole to which the patient is very allergic, and which can therefore no longer be prescribed. After a second opinion and a review of the literature, the patient was put on Pyrimethamine tablets and Albendazole with folic acid. The evolution was favorable with a significant regression of stools, resumption of appetite, and weight gain after one month. A last coproculture of control did not find any more oocysts of cystoisospora belli. In the face of chronic diarrhea, the systematic search for opportunistic germs in PLWHIV is essential. Management is possible.

show abstract

“…More than half of immunocompromised PLWHA experience diarrheas that can cause significant morbidity, contributing negatively to the quality of life and to adherence to antiretroviral therapy (ART). This may be due to a multitude of etiologies from infectious pathogens to malignancy to medications [4][5][6]. Over the past decade, due to the unprecedented increase in the use of ART, the incidence of diarrhea from opportunistic infections has decreased [6]; however, it remains a remarkable threat.…”

Section: Introductionmentioning

confidence: 99%

Global Burden of Cyclospora cayetanensis Infection and Associated Risk Factors in People Living with HIV and/or AIDS

Ramezanzadeh

Beloukas

Pagheh

et al. 2022

Viruses

View full text Add to dashboard Cite

Cyclospora cayetanensis infections remain one of the most common protozoan opportunistic causes of gastrointestinal diseases and diarrhea among people living with HIV and/or AIDS (PLWHA). This study was conducted to provide a summary of the evidence on the global burden of C. cayetanensis infection and associated risk factors among PLWHA. Scopus, PubMed, Science Direct, and EMBASE were searched up to February 2022. All original peer-reviewed original research articles were considered, including descriptive and cross-sectional studies describing C. cayetanensis in PLWHA. Incoherence and heterogeneity between studies were quantified by I index and Cochran’s Q test. Publication and population bias were assessed with funnel plots and Egger’s asymmetry regression test. All statistical analyses were performed using StatsDirect. The pooled prevalence of C. cayetanensis infection among PLWHA was 3.89% (95% CI, 2.62–5.40). The highest prevalence found in South America was 7.87% and the lowest in Asia 2.77%. In addition, the prevalence of C. cayetanensis was higher in PLWHA compared to healthy individuals. There was a relationship between a higher C. cayetanensis prevalence in PLWHA with a CD4 cell count below 200 cells/mL and people with diarrhea. The results show that PLWHA are more vulnerable to C. cayetanensis infection and emphasizes the need to implement the screening and prophylaxis tailored to the local context. Owing to the serious and significant clinical manifestations of the parasite, an early identification of seropositivity is recommended to initiate prophylaxis between PLWHA with a CD4 count ≤200 cells/mL and PLWHA who do not receive antiviral therapy.

show abstract

Chronic Cystoisospora belli infection in an HIV/AIDS patient treated at the specialized assistance service in Porto Velho County - Rondônia.

Cited by 5 publications

References 9 publications

Chronic Cystoisospora belli infection in a Colombian patient living with HIV and poor adherence to highly active antiretroviral therapy

Chronic Cystoisospora belli infection in a Colombian patient living with HIV and poor adherence to highly active antiretroviral therapy

Diagnostic and Therapeutic Difficulties of Chronic Diarrhea with <i>Cystoisospora belli</i> Inaugural Infection by the HIV at the NTHC-HKM of Cotonou: Literature Review

Global Burden of Cyclospora cayetanensis Infection and Associated Risk Factors in People Living with HIV and/or AIDS

Contact Info

Product

Resources

About

Chronic Cystoisospora belli infection in an HIV/AIDS patient treated at the specialized assistance service in Porto Velho County - Rondônia.

Cited by 5 publications

References 9 publications

Chronic Cystoisospora belli infection in a Colombian patient living with HIV and poor adherence to highly active antiretroviral therapy

Chronic Cystoisospora belli infection in a Colombian patient living with HIV and poor adherence to highly active antiretroviral therapy

Diagnostic and Therapeutic Difficulties of Chronic Diarrhea with &lt;i&gt;Cystoisospora belli&lt;/i&gt; Inaugural Infection by the HIV at the NTHC-HKM of Cotonou: Literature Review

Global Burden of Cyclospora cayetanensis Infection and Associated Risk Factors in People Living with HIV and/or AIDS

Contact Info

Product

Resources

About

Diagnostic and Therapeutic Difficulties of Chronic Diarrhea with <i>Cystoisospora belli</i> Inaugural Infection by the HIV at the NTHC-HKM of Cotonou: Literature Review