Chronic bullous disease of childhood, childhood cicatricial pemphigoid, and linear IgA disease of adults

Wojnarowska, Fenella; Marsden, R.A.; Bhogal, B.S.; Black, Martin M.

doi:10.1016/s0190-9622(88)70236-4

Cited by 328 publications

(250 citation statements)

References 32 publications

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“…Then triggering event such as: infection and subsequent treatment, may be required to initiate an immunologic response, even in patients who were not previously sensitized to the drug. 6,8,9 In our patient the blistering eruption occurred three weeks after the last dose of the cefuroxime axetil. The disease occurred probably because of two factors -drug and infection together.…”

Section: Figurementioning

confidence: 55%

Drug-induced linear IgA bullous dermatosis after discontinuation of cefuroxime axetil treatment

Pastuszczak¹,

Lipko-Godlewska²,

Jaworek³

et al. 2012

J Dermatol Case Rep

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Background: Linear immunoglobulin A (IgA) bullous dermatosis (LABD) is a rare autoimmune blistering disorder. The disease may be either idiopathic or druginduced. Over the past 30 years, approximately one hundred LABD cases have been described as induced by a wide range of drugs, chiefly antibiotics. Main observations:We report the case of 37-year-old woman who developed pruritic bullous lesions spread all over the body three weeks after her last dose of cefuroxime axetil. Antibiotic therapy was started due to rhino-sinusitis. Conclusions:In most reported cases of drug-induced LABD, skin lesions occur within the time of drug administration. However, the onset of disease may be even after discontinuation of treatment. It seems that in such cases, other clinical conditions (like infection) act, as cofactors of immunologic response. (J Dermatol Case Rep.

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Section: Figurementioning

confidence: 55%

Drug-induced linear IgA bullous dermatosis after discontinuation of cefuroxime axetil treatment

Pastuszczak¹,

Lipko-Godlewska²,

Jaworek³

et al. 2012

J Dermatol Case Rep

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“…In a series of 25 children with CBDC, 16 cases presented remission within 2 years, while three patients still had persistent disease post puberty [23,30].…”

Section: Prognosismentioning

confidence: 99%

“…In a series of 25 cases of childhood CBDC, 38% of them had either preceding infection or ingestion of drugs [23]. Drugs may serve as haptens, completing complexes with dermal/epidermal proteins, and eliciting an autoimmune response.…”

Section: Pathophysiology and Autoimmunitymentioning

confidence: 99%

Chronic Bullous Disease or Linear IgA Dermatosis of Childhood -Revisited

Patsatsi¹

2013

J Genet Syndr Gene Ther

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Linear IgA dermatosis or chronic bullous disease of childhood (CBDC) is a nonhereditary, autoimmune subepidermal bullous disease, characterized by the presence of continuous linear deposits of IgA autoantibodies along the basement membrane zone. Antigens mainly involved in the pathogenesis of CBDC are a 97-kDa and a 120 -kDa protein, which represent fragments of the extracellular domain of collagen XVII (BP180), a transmembrane protein playing a critical role in maintaining the linkage between the intracellular and the extracellular structural elements involved in epidermal adhesion. Humoral and cellular response contributes to the pathogenetic mechanism leading to blister formation. CBDC is characterized by a clinical polymorphism in each patient, with the "cluster of jewels" pattern being the most typical clinical lesion. For the establishment of CBDC diagnosis, combination of histology and immunofluorescence studies are of utmost importance. The majority of patients respond to dapsone, sulfapiridine or systemic steroids in cases of widespread disease. CBDC tends to resolve spontaneously within several months to 5 years after its onset. In this review article, the key features of this rare autoimmune bullous disease are revisited.

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“…8 El compromiso de mucosas es mucho menos frecuente que en adultos, principalmente en la cavidad oral y los genitales. 1,9 La histopatología característica consiste en ampollas subepidérmicas con infiltrado inflamatorio de neutrófilos y/o eosinófilos en la dermis. La inmunofluorescencia directa es clave para poder realizar el diagnóstico; muestra el depósito predominantemente lineal de IgA a lo largo de la membrana basal en la piel normal y perilesional.…”

Section: Figura 2 Tronco Se Destaca Una Ampolla De Forma Anular Y Cunclassified

Dermatosis IgA lineal de la infancia: reporte de un caso

2014

Arch Argent Pediat

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Chronic bullous disease of childhood, childhood cicatricial pemphigoid, and linear IgA disease of adults

Cited by 328 publications

References 32 publications

Drug-induced linear IgA bullous dermatosis after discontinuation of cefuroxime axetil treatment

Drug-induced linear IgA bullous dermatosis after discontinuation of cefuroxime axetil treatment

Chronic Bullous Disease or Linear IgA Dermatosis of Childhood -Revisited

Dermatosis IgA lineal de la infancia: reporte de un caso

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