Chronic Arthritis in Goats Caused by a Retrovirus

Abstract

A virus was isolated from an adult goat with chronic arthritis and shown to belong to the retrovirus group by electron microscopy and biochemical methods. Inoculation of the virus into cesarean-derived specific-pathogen-free goats' kids produced arthritic lesions similar to those in the spontaneous disease. Vrus was reisolated from the experimentally induced lesions.

Antigenic Variation of Caprine Arthritis-Encephalitis Virus during Persistent Infection of Goats

“…Cloned virus 095 D was shown to cause a syncytial c.p.e, and have similar kinetics of replication and cell fusion to the inoculum virus, and to other CAEV isolates described previously (Ellis et al, 1985;Ellis, 1986). The virus formed by C-type budding from cytoplasmic membranes and had the same dimensions and morphology as reported for other isolates of CAEV (Narayan et al, 1980;Crawford et al, 1980;Dahlberg et al, 1981). Additionally, a common antigen in virus 095 D and virus 020 was demonstrated by the use of AGID tests.…”

Produção de antígeno nucleoprotéico do vírus da artrite-encefalite caprina e comparação com o do vírus Maedi-Visna para utilização em teste de imunodifusão em ágar gel

“…Para a produção do Ag foi utilizada a amostra de CAEV 3 isolada nos Estados Unidos da América (Crawford et al 1980) replicada em células de MSC. Para isto, 1ml de suspensão viral estocada em N 2 líquido foi diluída 1:10 e inoculada (2ml por garrafa de 75cm 2 de área de cultivo) em monocamadas subconfluentes.…”

An Epidemic of Caprine Arthritis Encephalitis in Japan: Isolation of the Virus

“…CAE has been identified in most goatrearing countries around the world [2,15]. Most infected goats develop specific antibodies which persist for life [1,6], and the detection of antibodies can be taken as proof of the presence of the viral infection [3,15]. However, only some of the infected goats, less than 10%, develop clinical disease characterized by chronic persistent arthritis, mastitis, respiratory distress and encephalitis [6,7,15,16,24].…”

“…Caprine arthritis-encephalitis (CAE) is a disease of domestic goats caused by a lentivirus of the family Retroviridae [5,6]. CAE has been identified in most goatrearing countries around the world [2,15].…”

“…Most infected goats develop specific antibodies which persist for life [1,6], and the detection of antibodies can be taken as proof of the presence of the viral infection [3,15]. However, only some of the infected goats, less than 10%, develop clinical disease characterized by chronic persistent arthritis, mastitis, respiratory distress and encephalitis [6,7,15,16,24]. The time between the moment of infection and the development of detectable levels of antibody and the onset of clinical disease may vary from months to years [1,18].…”