Chronic Acquired Demyelinating Symmetric Polyneuropathy Classified by Pattern of Weakness

Abstract

Classification by presence or absence of proximal weakness separates patients with chronic acquired symmetric demyelinating polyneuropathy into groups that are different in clinical course, disability, and treatment response.

Prognosis and outcome in patients with chronic inflammatory demyelinating polyradiculoneuropathy in a tertiary center in Oman

“…In our study, there was a male predominance among the patients with CIDP in Oman with a male-to-female ratio of 1.6:1, which is similar to some other studies, 9 - 14 while other studies reported different ratios: Rajabally et al: 2.3:1, 15 Chio et al: 2.1:1, 16 Mahdi-Rogers and Hughes: 1.9:1, 17 and Abraham et al: 4:1. 18 …”

“…The average age of onset was 43 years, similar to the Okhovat et al 19 study at 40 years, while Mygland and Monstad 14 reported a mean age of 48 years. However, some studies stated older ages of onset ranging from 53 to 61 years.…”

“…Mixed sensory motor manifestations were predominant in our study, with a percentage of 65%, while Rentzos et al 9 reported 92%, and Mygland and Monstad 14 reported 100% of patients with mixed sensory and motor manifestations. The distal manifestation was predominant in 57% of patients, as reported by Panaite et al, 26 and 82.6% showed symmetrical presentations, which is similar to Rentzos et al 9 …”

Prognosis and outcome in patients with chronic inflammatory demyelinating polyradiculoneuropathy in a tertiary center in Oman

“…In our study, there was a male predominance among the patients with CIDP in Oman with a male-to-female ratio of 1.6:1, which is similar to some other studies, 9 - 14 while other studies reported different ratios: Rajabally et al: 2.3:1, 15 Chio et al: 2.1:1, 16 Mahdi-Rogers and Hughes: 1.9:1, 17 and Abraham et al: 4:1. 18 …”

“…The average age of onset was 43 years, similar to the Okhovat et al 19 study at 40 years, while Mygland and Monstad 14 reported a mean age of 48 years. However, some studies stated older ages of onset ranging from 53 to 61 years.…”

“…Mixed sensory motor manifestations were predominant in our study, with a percentage of 65%, while Rentzos et al 9 reported 92%, and Mygland and Monstad 14 reported 100% of patients with mixed sensory and motor manifestations. The distal manifestation was predominant in 57% of patients, as reported by Panaite et al, 26 and 82.6% showed symmetrical presentations, which is similar to Rentzos et al 9 …”

CIDP With and Without Monoclonal Gammopathy of Undetermined Significance ( MGUS ): Comparison of Clinical Phenotype, Diagnostic Features, and Treatment Response

“…Previous studies, varying in used screening techniques, inclusion criteria, and sample characteristics, reported an IgG paraproteinemia prevalence of 0%-17% in patients with CIDP [7,[21][22][23][24][25][26][27][28][29][30]. In most studies, the prevalence of IgM paraproteinemia seemed higher than IgG paraproteinemia in patients with CIDP, but those studies did not exclude patients with anti-MAG, unlike ours [24,[26][27][28]31].…”

Onset and course of chronic inflammatory demyelinating polyneuropathy

“…Among the patients with proximal weakness, 55% were in remission at follow‐up, compared with none of the DADS patients. Based partly on the same material, we have previously shown that the presence of proximal weakness is associated with a higher incidence of relapsing course and a better response to treatment than that seen in the distal or purely sensory phenotype 7…”

Prognosis and outcome in patients with chronic inflammatory demyelinating polyradiculoneuropathy in a tertiary center in Oman

“…In our study, there was a male predominance among the patients with CIDP in Oman with a male-to-female ratio of 1.6:1, which is similar to some other studies, 9 - 14 while other studies reported different ratios: Rajabally et al: 2.3:1, 15 Chio et al: 2.1:1, 16 Mahdi-Rogers and Hughes: 1.9:1, 17 and Abraham et al: 4:1. 18 …”

“…The average age of onset was 43 years, similar to the Okhovat et al 19 study at 40 years, while Mygland and Monstad 14 reported a mean age of 48 years. However, some studies stated older ages of onset ranging from 53 to 61 years.…”

“…Mixed sensory motor manifestations were predominant in our study, with a percentage of 65%, while Rentzos et al 9 reported 92%, and Mygland and Monstad 14 reported 100% of patients with mixed sensory and motor manifestations. The distal manifestation was predominant in 57% of patients, as reported by Panaite et al, 26 and 82.6% showed symmetrical presentations, which is similar to Rentzos et al 9 …”

CIDP With and Without Monoclonal Gammopathy of Undetermined Significance ( MGUS ): Comparison of Clinical Phenotype, Diagnostic Features, and Treatment Response

“…Previous studies, varying in used screening techniques, inclusion criteria, and sample characteristics, reported an IgG paraproteinemia prevalence of 0%-17% in patients with CIDP [7,[21][22][23][24][25][26][27][28][29][30]. In most studies, the prevalence of IgM paraproteinemia seemed higher than IgG paraproteinemia in patients with CIDP, but those studies did not exclude patients with anti-MAG, unlike ours [24,[26][27][28]31].…”

Onset and course of chronic inflammatory demyelinating polyneuropathy

“…Among the patients with proximal weakness, 55% were in remission at follow‐up, compared with none of the DADS patients. Based partly on the same material, we have previously shown that the presence of proximal weakness is associated with a higher incidence of relapsing course and a better response to treatment than that seen in the distal or purely sensory phenotype 7…”

Prognosis and outcome in patients with chronic inflammatory demyelinating polyradiculoneuropathy in a tertiary center in Oman

“…In our study, there was a male predominance among the patients with CIDP in Oman with a male-to-female ratio of 1.6:1, which is similar to some other studies, 9 - 14 while other studies reported different ratios: Rajabally et al: 2.3:1, 15 Chio et al: 2.1:1, 16 Mahdi-Rogers and Hughes: 1.9:1, 17 and Abraham et al: 4:1. 18 …”

“…The average age of onset was 43 years, similar to the Okhovat et al 19 study at 40 years, while Mygland and Monstad 14 reported a mean age of 48 years. However, some studies stated older ages of onset ranging from 53 to 61 years.…”

“…Mixed sensory motor manifestations were predominant in our study, with a percentage of 65%, while Rentzos et al 9 reported 92%, and Mygland and Monstad 14 reported 100% of patients with mixed sensory and motor manifestations. The distal manifestation was predominant in 57% of patients, as reported by Panaite et al, 26 and 82.6% showed symmetrical presentations, which is similar to Rentzos et al 9 …”

CIDP With and Without Monoclonal Gammopathy of Undetermined Significance ( MGUS ): Comparison of Clinical Phenotype, Diagnostic Features, and Treatment Response

“…Previous studies, varying in used screening techniques, inclusion criteria, and sample characteristics, reported an IgG paraproteinemia prevalence of 0%-17% in patients with CIDP [7,[21][22][23][24][25][26][27][28][29][30]. In most studies, the prevalence of IgM paraproteinemia seemed higher than IgG paraproteinemia in patients with CIDP, but those studies did not exclude patients with anti-MAG, unlike ours [24,[26][27][28]31].…”

Onset and course of chronic inflammatory demyelinating polyneuropathy

“…Among the patients with proximal weakness, 55% were in remission at follow‐up, compared with none of the DADS patients. Based partly on the same material, we have previously shown that the presence of proximal weakness is associated with a higher incidence of relapsing course and a better response to treatment than that seen in the distal or purely sensory phenotype 7…”