Chronic (89-week) feeding study with hydroxypropyl distarch phosphate, starch acetate, lactose and sodium alginate in mice

Chemical, Functional and Biological Properties of Modified Corn Starch

“…In this respect, Cervenka and Kay (1963) reported that no adverse effects were observed on blood chemistry such as, urine parameters and liver functions in rats groups after given gelatine capsules containing 50, 250 and1250 mg modified starch/kg b.wt. This results differs from the results of Til et al(1986) who found slight urinary changes in rats fed on hydroxypropyl distarch phosphate and starch acetate.…”

“…These ratings are higher in WAC and viscosity and thus influencing the emptying and digestion of other compounds in the gut digestal ( Raben et al,1997 andEbihara et al,1998 ) . These results are in agreement with Til et al (1986) who reported that feeding on hydroxypropyl distarch phosphate and starch acetate caused slightly lower body weights. Also, feeding on five chemically modified starches ( acetylated distarch phosphate, acetylated diamylopectin phosphate, starch acetate, hydroxypropyl distarch glycerol and phosphated distarch phosphate reduced body weights except that of the phosphated distarch phosphate ( deGroot et al,1974 ).…”

Chemical, Functional and Biological Properties of Modified Corn Starch

“…In this respect, Cervenka and Kay (1963) reported that no adverse effects were observed on blood chemistry such as, urine parameters and liver functions in rats groups after given gelatine capsules containing 50, 250 and1250 mg modified starch/kg b.wt. This results differs from the results of Til et al(1986) who found slight urinary changes in rats fed on hydroxypropyl distarch phosphate and starch acetate.…”

“…These ratings are higher in WAC and viscosity and thus influencing the emptying and digestion of other compounds in the gut digestal ( Raben et al,1997 andEbihara et al,1998 ) . These results are in agreement with Til et al (1986) who reported that feeding on hydroxypropyl distarch phosphate and starch acetate caused slightly lower body weights. Also, feeding on five chemically modified starches ( acetylated distarch phosphate, acetylated diamylopectin phosphate, starch acetate, hydroxypropyl distarch glycerol and phosphated distarch phosphate reduced body weights except that of the phosphated distarch phosphate ( deGroot et al,1974 ).…”

The safety of PolyGlycopleX® (PGX®) as shown in a 90-day rodent feeding study

“…The observed effects of this study have been reported in previous high dose studies of similar substances in rats, and can be explained in terms of the predictable physiological adaptive response to a high level of both indigestible and fermentable dietary fibers [ 21 , 36 , 37 ]. In the present study, no differences in any organ tissue under histopathological analysis were observed between control and treated animals, supporting the hypothesis that the observed minimal clinical changes were adaptive in nature and/or a result of the increased urinary volume.…”

Clear Evidence of Carcinogenic Activity by a Whole-Leaf Extract of Aloe barbadensis Miller (Aloe vera) in F344/N Rats

“…Dilatation of the rodent cecum, often accompanied with severe diarrhea, has been reported for a variety of compounds (Birnbaum et al, 1986;Courtney, 2000;Leegwater et al, 1974; TWO-YEAR CARCINOGENESIS STUDY OF ALOE VERA Smits-Van Prooije et al, 1990;Til et al, 1986). Polydipsia, diarrhea, and cecal dilatation were common observances in this study, and cecal dilatation was the noted cause of death for a number of rats.…”

Chemical, Functional and Biological Properties of Modified Corn Starch

“…In this respect, Cervenka and Kay (1963) reported that no adverse effects were observed on blood chemistry such as, urine parameters and liver functions in rats groups after given gelatine capsules containing 50, 250 and1250 mg modified starch/kg b.wt. This results differs from the results of Til et al(1986) who found slight urinary changes in rats fed on hydroxypropyl distarch phosphate and starch acetate.…”

“…These ratings are higher in WAC and viscosity and thus influencing the emptying and digestion of other compounds in the gut digestal ( Raben et al,1997 andEbihara et al,1998 ) . These results are in agreement with Til et al (1986) who reported that feeding on hydroxypropyl distarch phosphate and starch acetate caused slightly lower body weights. Also, feeding on five chemically modified starches ( acetylated distarch phosphate, acetylated diamylopectin phosphate, starch acetate, hydroxypropyl distarch glycerol and phosphated distarch phosphate reduced body weights except that of the phosphated distarch phosphate ( deGroot et al,1974 ).…”

The safety of PolyGlycopleX® (PGX®) as shown in a 90-day rodent feeding study

“…The observed effects of this study have been reported in previous high dose studies of similar substances in rats, and can be explained in terms of the predictable physiological adaptive response to a high level of both indigestible and fermentable dietary fibers [ 21 , 36 , 37 ]. In the present study, no differences in any organ tissue under histopathological analysis were observed between control and treated animals, supporting the hypothesis that the observed minimal clinical changes were adaptive in nature and/or a result of the increased urinary volume.…”

Clear Evidence of Carcinogenic Activity by a Whole-Leaf Extract of Aloe barbadensis Miller (Aloe vera) in F344/N Rats

“…Dilatation of the rodent cecum, often accompanied with severe diarrhea, has been reported for a variety of compounds (Birnbaum et al, 1986;Courtney, 2000;Leegwater et al, 1974; TWO-YEAR CARCINOGENESIS STUDY OF ALOE VERA Smits-Van Prooije et al, 1990;Til et al, 1986). Polydipsia, diarrhea, and cecal dilatation were common observances in this study, and cecal dilatation was the noted cause of death for a number of rats.…”

Chemical, Functional and Biological Properties of Modified Corn Starch

“…In this respect, Cervenka and Kay (1963) reported that no adverse effects were observed on blood chemistry such as, urine parameters and liver functions in rats groups after given gelatine capsules containing 50, 250 and1250 mg modified starch/kg b.wt. This results differs from the results of Til et al(1986) who found slight urinary changes in rats fed on hydroxypropyl distarch phosphate and starch acetate.…”

“…These ratings are higher in WAC and viscosity and thus influencing the emptying and digestion of other compounds in the gut digestal ( Raben et al,1997 andEbihara et al,1998 ) . These results are in agreement with Til et al (1986) who reported that feeding on hydroxypropyl distarch phosphate and starch acetate caused slightly lower body weights. Also, feeding on five chemically modified starches ( acetylated distarch phosphate, acetylated diamylopectin phosphate, starch acetate, hydroxypropyl distarch glycerol and phosphated distarch phosphate reduced body weights except that of the phosphated distarch phosphate ( deGroot et al,1974 ).…”

The safety of PolyGlycopleX® (PGX®) as shown in a 90-day rodent feeding study

“…The observed effects of this study have been reported in previous high dose studies of similar substances in rats, and can be explained in terms of the predictable physiological adaptive response to a high level of both indigestible and fermentable dietary fibers [ 21 , 36 , 37 ]. In the present study, no differences in any organ tissue under histopathological analysis were observed between control and treated animals, supporting the hypothesis that the observed minimal clinical changes were adaptive in nature and/or a result of the increased urinary volume.…”

Clear Evidence of Carcinogenic Activity by a Whole-Leaf Extract of Aloe barbadensis Miller (Aloe vera) in F344/N Rats

“…Dilatation of the rodent cecum, often accompanied with severe diarrhea, has been reported for a variety of compounds (Birnbaum et al, 1986;Courtney, 2000;Leegwater et al, 1974; TWO-YEAR CARCINOGENESIS STUDY OF ALOE VERA Smits-Van Prooije et al, 1990;Til et al, 1986). Polydipsia, diarrhea, and cecal dilatation were common observances in this study, and cecal dilatation was the noted cause of death for a number of rats.…”