1979
DOI: 10.1007/bf00295589 View full text |Buy / Rent full text
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Abstract: The incidence of chromosome breakage was found to be elevated in 42 patients with Crohn's disease. This phenomenon was much more striking in cultures set up with TCM 199 than in cultures set up with RPMI 1629 rich in L-cysteine. The drug D-penicillamine, a close analog of L-cysteine, gave an apparent therapeutic response in several patients and reduced the chromosome breakage frequency in the lymphocytes of these patients in vitro and in vivo.

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“…Recent results with CFs from SLE, Crohn disease, and NZB mice point towards deficiencies in the detoxification of superoxide radicals in these diseases. Addition of superoxide dismutase or the radical scavengers penicillamine and cysteine strongly reduced the clastogenic activities of serum ultrafiltrates (19,30,31). As shown in the present work, superoxide dismutase also strongly suppresses the clastogenic activity of concentrated ultrafiltrates of culture media of BS fibroblasts.…”
Section: Methodssupporting
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rupbmjkragerfmgwileyiopcupepmcmbcthiemesagefrontiersapsiucrarxivemeralduhksmucshluniversity-of-gavle
“…Recent results with CFs from SLE, Crohn disease, and NZB mice point towards deficiencies in the detoxification of superoxide radicals in these diseases. Addition of superoxide dismutase or the radical scavengers penicillamine and cysteine strongly reduced the clastogenic activities of serum ultrafiltrates (19,30,31). As shown in the present work, superoxide dismutase also strongly suppresses the clastogenic activity of concentrated ultrafiltrates of culture media of BS fibroblasts.…”
Section: Methodssupporting
“…As expected [3], increased breaks were found in a female child with classical incontinentia pigmenti ( Table I).…”
Section: Cytogeneticsmentioning
“…"~ High levels of free radicals may also explain the increased chromosomal breakage which occurs in lymphocytes of CD patients. 297 Although the chemotherapy data do not exclude mycobacterial involvement in some cases of CD, neither do they provide definitive proof. Clearly their role, if any, is only contributory as demonstrated from the results of therapeutic regimens with antimicrobial and anti-inflammatory agents.…”
Section: Eficacy Of Anti-mycobacterial Drugs Against the Mai Complexmentioning