Chromosomal Abnormalities and Menstrual Cycle Disorders

Abstract

Chromosomal abnormalities have long been recognized as a cause of menstrual cycle disorders, premature ovarian insufficiency, and recurrent pregnancy loss. In women with X chromosome abnormalities, premature ovarian insufficiency is mainly a consequence of ovarian follicle depletion, due to insufficient initial follicle number and/or spontaneous accelerated follicle loss. The level of X chromosome mosaicism and its reproductive significance is still under debate. In our study, we evaluated the contribution of X chromosome abnormalities in women with sporadic idiopathic premature ovarian insufficiency (POI) and in women with a history of recurrent pregnancy loss. The results show that X aneuploidy and low-level mosaicism have reproductive significance in the phenotypically normal women with recurrent pregnancy loss and/or fertility problems. These results have practical implications for genetic counseling and fertility treatment.

Magnitude and associated factors of menstrual irregularity among undergraduate students of Debre Berhan University, Ethiopia

“…According to a previous study regular menstrual cycle (counting from the first day of one menstrual period to the first day of the next cycle) is 21 to 35 days and lasts from 3 to 7 days duration with a volume of blood loss of 5-80 ml [2]. Otherwise, menstrual irregularity refers to any kind of changes occurring irregularity of onset, frequency of onset, duration of flow, and volume from the regular menstrual cycle [3][4][5]. The regular cycle at puberty depends on a complex series of interactions involving the hypothalamus, anterior pituitary, and ovaries.…”