Chromophobe Cell Carcinoma of the Kidney

Akhtar, Mohammed; Kardar, Hafeez; Linjawi, T.; McClintock, Joseph; Ali, Muhammad

doi:10.1097/00000478-199511000-00004

Cited by 149 publications

(15 citation statements)

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“…It has been shown that metastatic chromophobe RCC progressed more indolently than other variants 82 . Lymph node metastasis and infiltration of neighboring organs are rare, but nevertheless occur 6,83–85 . The proclivity for hepatic metastases might distinguish chromophobe RCC from other subtypes of RCC, which tend to spread to bone or lungs 86 …”

Section: Prognosis and Predictive Factorsmentioning

confidence: 99%

“…Sarcomatoid transformation, which historically was considered to be a distinctive histopathological entity, has been described in virtually every type of RCCs and represents a common pathway of transformation to a higher‐grade malignancy. Chromophobe RCC with sarcomatoid transformation are uncommon, and the presence of sarcomatoid changes is associated with a more aggressive clinical course 79,83,87 . Single reported cases showed large pleomorphic spindle or polygonal cells with large hyperchromatic nuclei and high mitotic activity.…”

Section: Prognosis and Predictive Factorsmentioning

confidence: 99%

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Molecular pathology of chromophobe renal cell carcinoma: A review

Yusenko

2010

Int J of Urology

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Abstract:The recognition of chromophobe renal cell carcinoma (RCC) among other distinct types of renal cell tumors (RCT) based on light-microscopic features, such as cytoplasmic and nuclear characteristics, might pose a dilemma in some cases because of morphological pattern overlapping with renal oncocytoma or conventional RCC. The present article reviews chromophobe RCC with focus on aspects of its molecular pathology, which was shown using ancillary modern microarray-based technology that can distinguish it from its mimics and therefore be helpful for its correct diagnosis. Although the high resolution DNA-microarray analyses excluded with all certainty the occurrence of small specific alterations, the loss of entire chromosomes 2, 10, 13, 17 and 21 occurs exclusively in chromophobe RCC and therefore probes localized at these chromosomes might be used to establish the diagnosis of chromophobe RCC in cases with uncertain histology. The usefulness of proposed candidate genes selected by the global gene expression analyses in the diagnostic pathology is far below expectations. The conflicting staining patterns, together with the poor specificity of used antibodies, leads us to believe that these candidate immunomarkers might not help in the separation of chromophobe RCC, with the exception of CD82, which has recently been suggested to be used for routine histological diagnosis.Key words: chromophobe renal cell carcinoma, diagnosis, electron microscopy, histology, molecular markers. Prehistory and epidemiologyBased on its morphological and electron-microscopic characteristics, chromophobe renal cell carcinoma (RCC) was delineated among experimental kidney tumors nitrosomorpholine-induced in rats.1 In 1985, Thoenes et al. described the first human renal carcinomas as an analogy to the cases in rodents showing similar morphology.2 They noticed a 4.6% incidence of the chromophobe variant in a series of 697 renal cell carcinoma cases. Initially, diagnosis of chromophobe RCC appeared to be straightforward as a result of its characteristic light microscopic features. The same authors 3 years later described an eosinophilic variant of chromophobe RCC, which can easily be confused with renal oncocytoma or "eosinophilic" clear cell carcinoma based on morphological characteristics.3 The latter discovery is also related to its close phenotypic similarity to "eosinophilic" clear cell carcinoma on the one hand and to oncocytoma on the other hand. Presently, chromophobe RCC is considered to account for approximately 5% of all cases of renal cell carcinoma. The mean age of incidence with chromophobe RCC in a series of 104 patients reported by Cindolo et al. 4 was in the sixth decade (58 years), with a range in age of 27-86 years, and the number of men and women was roughly equal. Mortality was less than 10%.

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Section: Prognosis and Predictive Factorsmentioning

confidence: 99%

Section: Prognosis and Predictive Factorsmentioning

confidence: 99%

Molecular pathology of chromophobe renal cell carcinoma: A review

Yusenko

2010

Int J of Urology

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“…Chromophobe renal cell carcinoma (chRCC) accounts for approximately 5% of surgically removed renal cell tumours (RCT). Although chRCC has a better prognosis than conventional or papillary RCC, it is a malignant tumour with a tendency to sarcomatous transformation and metastatic growth in around 10% of cases 1–4 . Renal oncocytoma (RO), in spite of growth into small veins or ‘infiltration’ of the parenchyma or perinephric fatty tissue, is a benign tumour 5 .…”

Section: Introductionmentioning

confidence: 99%

Identifying CD82 (KAI1) as a marker for human chromophobe renal cell carcinoma

Yusenko

Kovács

2009

Histopathology

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“…In the majority of cases, it is taken for granted that this type of RCC arises from a clear or granular RCC [45]. Sarcomatoid tumours derived from papillary, chromophobe, and collecting duct carcinoma have been reported, however, demonstrating that every type of RCC possesses the potential for progression to sarcomatoid carcinoma [4,6,45]. The presence of epithelial components would lead to a diagnosis of sarcomatoid carcinoma in tumours with mostly spindle cells before we could consider them to be other renal sarcomas.…”

Section: Discussionmentioning

confidence: 99%

Differential expression of SHP2, a protein-tyrosine phosphatase with SRC homology-2 domains, in various types of renal tumour

Hayashi¹,

Matozaki

Hanioka³

et al. 1998

Virchows Archiv

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SHP2, a widely distributed protein-tyrosine phosphatase with src homology-2 (SH2) domains, is highly expressed in the brain and may play a role in synaptic communications or cellular proliferation. In this study, we examined SHP2 protein expression in 110 renal cell tumours of various histological subtypes, including clear, granular, papillary, chromophobe, collecting duct, and sarcomatoid-type renal cell carcinoma (RCC), and oncocytoma. SHP2 was expressed predominantly in normal distal tubules and collecting ducts, and positivity in various types of renal tumours was as follows: clear cell RCC, 0% (0/77 cases); granular, 7.7% (1/13); papillary, 50% (3/6); sarcomatoid, 0% (0/1); chromophobe, 85.7% (6/7); collecting duct carcinoma, 0% (0/2); oncocytoma, 100% (4/4). Clear and granular-type RCCs showed a very low but positive expression of SHP2. Chromophobe RCC and oncocytoma showed the highest rates and strongest intensities of SHP2 protein on immunostaining. SHP2 may serve as a powerful marker in detecting rare tumours. Estimates of its expression may be useful in histological diagnosis.

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Chromophobe Cell Carcinoma of the Kidney

Cited by 149 publications

References 0 publications

Molecular pathology of chromophobe renal cell carcinoma: A review

Molecular pathology of chromophobe renal cell carcinoma: A review

Identifying CD82 (KAI1) as a marker for human chromophobe renal cell carcinoma

Differential expression of SHP2, a protein-tyrosine phosphatase with SRC homology-2 domains, in various types of renal tumour

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