Chromomycosis. Treatment with thiabendazole

Repurposing Benzimidazoles against Causative Agents of Chromoblastomycosis: Albendazole Has Superior In Vitro Activity Than Mebendazole and Thiabendazole

“…Albendazole, mebendazole, and thiabendazole showed in vitro antifungal activity against F. pedrosoi in the initial screening of the NCC library. In the past, thiabendazole has been used to treat CBM [57,[71][72][73][74], however its use was discouraged due to relapses of the disease [75]. Among the benzimidazoles, albendazole was the one that presented the lowest MIC values, and consequently, the greatest selectivity against CBM agents.…”

Successful treatment of chromomycosis using carbon dioxide laser associated with topical heat applications

“…Treatment of chromomycosis is aimed at eradication through the use of a variety of antifungal medications. Systemic agents, such as 5‐fluorocytosine (5‐FU), 1 thiabendazole, 2 amphotericine B, 3 ketoconazole, 4 and miconazole 5 are used for chronic and extensive lesions. Recently, we also found reports on the use of newer antifungal drugs, such as itraconazole, 6 fluconazole, 7 and terbinafine 8 .…”

ITRACONAZOLE IN THE TREAMENT OF CHROMOBLASTOMYCOSIS DUE TO FONSECAEA PEDROSOI

“…The length of drug administration mu.st be guided by the application of clinical, mycologic, and histopathologic criteria. The severe cases in our trial satisfied the criteria of clinical healing or clinical improvement, but in these patients parasites were still present at the control biopsies, showing that sterilization of their lesions was not ob- 12 3 4 5 6 7 9 10 1112 13 14 15 Patient No. taincd.…”