Journal of Chromatography A 2012 DOI: 10.1016/j.chroma.2012.03.015 View full text
Mayuratheepan Puthirasigamany, Peter van Beijeren, Peter Kreis

Abstract: Therapeutic proteins are biotechnological products with a fast-growing market. Despite the rapid development of available process technologies, a bottleneck in production capacities is still present due to limitations in the associated downstream process, particularly within chromatographic purification steps. Membrane chromatography has been introduced as a promising alternative for conventional chromatography because it allows for higher throughputs but it does not deliver comparable dynamic binding capaciti…

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