Choroidal Thickness in Behcet's Uveitis: An Enhanced Depth Imaging-Optical Coherence Tomography and Its Association With Angiographic Changes

Kim, Min; Kim, Hye‐Sun; Kwon, Hee Jung; Kim, Sung Soo; Koh, Hyoung Jun; Lee, Sung Chul

doi:10.1167/iovs.13-12231

Cited by 137 publications

(98 citation statements)

References 25 publications

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“…Previous studies, by using EDI OCT, have shown choroidal thickening in acute phases of both Behçet's disease 21 and Vogt-Koyanagi-Harada syndrome. 22,23 It is known that mydriatic agents including cyclopentolate can be used not only for the pupil dilation before the evaluation of ChT by EDI OCT but also for the treatment 24 of these aforementioned diseases.…”

Section: Discussionmentioning

confidence: 97%

The effect of topical anti-muscarinic agents on subfoveal choroidal thickness in healthy adults

Öner

Bulut

Öter

2016

Eye

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Purpose To investigate the effects of tropicamide and cyclopentolate, which are two anti-muscarinic agents commonly used in the ophthalmologic practice, on subfoveal choroidal choroidal thickness (ChT) in healthy adults. Methods A total of 74 healthy adult subjects were enrolled in the study. Subjects were randomly divided into two groups: (1) cyclopentolate group (n = 37) in which the right eye (study eye) of each subject received topical cyclopentolate 1%, and the fellow eye (control eye) received artificial tears and (2) tropicamide group (n = 37) in which the right eye (study eye) of each subject received topical tropicamide 1% and the fellow eye (control eye) received artificial tears. Each topical medication was applied three times with 10-min intervals. ChT measurements were performed at baseline and 40 min after the last drops of the topical medications by enhanced depth imaging (EDI) optical coherence tomography (OCT). Results In the cyclopentolate group, subfoveal ChT significantly increased in the study eyes (P = 0.013), whereas it did not significantly change in the control eyes (P = 0.417). On the other hand, in the tropicamide group, no significant subfoveal ChT changes were observed in either the study eyes (P = 0.715) or the control eyes (P = 0.344). Conclusions The current study demonstrated that cyclopentolate caused significant choroidal thickening, whereas tropicamide had no significant effect on ChT in healthy adults. As a result, mydriasis by cyclopentolate may complicate ChT measurements by EDI OCT. Use of tropicamide may provide more reliable results for evaluation of ChT in ocular pathologies.

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Section: Discussionmentioning

confidence: 97%

The effect of topical anti-muscarinic agents on subfoveal choroidal thickness in healthy adults

Öner

Bulut

Öter

2016

Eye

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“…The CT in myopia also has a positive correlation with final visual acuity. 21,22 In polypoidal choroidal vasculopathy, 23 Vogt-Koyanagi-Harada disease, 24 and Behçet's disease, 25 the choroid is thickened during the active phase and thereafter shows progressive thinning. The CT, therefore, has the potential to be used as a parameter to monitor the activity of these diseases.…”

Section: Discussionmentioning

confidence: 99%

Subfoveal choroidal thickness as a predictor of central serous chorioretinopathy

Ambiya

Yogi

et al. 2016

Eye

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Purpose The purpose of the study was to evaluate the role of subfoveal choroidal thickness (CT) measurements as a predictor for the course of central serous chorioretinopathy (CSC). Patients and methods Thirty-eight eyes of 33 patients with CSC were analyzed retrospectively. Key inclusion criteria were naive (acute or recurrent) CSC; a minimum of 12 months of follow up; and the availability of good quality enhanced depth imaging SD-OCT images at each visit. Eyes with changes suggestive of chronic CSC and history of any treatment were excluded. Collected data included demographic profile, visual acuity, subfoveal CT, central macular thickness (CMT), and treatment details. Univariate and multivariate analyses for association of baseline features with need for treatment were performed. On the basis of results of this analysis, the 38 eyes were divided into two groups: Group A (subfoveal CT ≤ 356 μm) and Group B (subfoveal CT4356 μm). Results On univariate analysis, the need for treatment had significantly positive correlation with duration of symptoms (P = 0.02), negative correlation with the baseline CT (Po0.01), and no significant correlation with CMT (P = 0.13). On multivariate regression analysis, only baseline CT had a statistically significant association with the need for treatment (odds ratio (OR), 0.989; CI, 0.979-0.999; P = 0.048). Group A eyes were more likely to require treatment (Group A: 54.55%, 12 of 22 eyes; Group B: 18.75%, 3 of 16 eyes; OR: 5.2, 95% CI, 1.15-23.54; P = 0.04). There was a significant decrease in subfoveal CT in Group B (−105.62 ± 108.91 μm; P = 0.002). Conclusion CSC with a subfoveal CT ≤ 356 μm is of chronic nature and is more likely to require treatment rather than observation.

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“…9 With the advent of enhanced depth imaging optical coherence tomography (EDI-OCT), changes in choroidal thickness (CT) have been reported in chorioretinal diseases such as DMO, age-related macular degeneration, and uveitis. [13][14][15] Recent studies have revealed mixed results of either increased or decreased CT relating to disease severity or response to treatments for DMO. 14,16 Although the clinical implication of changes in CT and its exact role in the pathophysiology of DMO remains undetermined, it would be clinically meaningful to study the changes of the choroid and evaluate the potential role of subfoveal CT as a biomarker for treatment response after IVD as many previous studies have implicated choroidal changes and its potential role in the pathophysiology of DMO.…”

Section: Introductionmentioning

confidence: 99%

Effect of intravitreal dexamethasone implant on retinal and choroidal thickness in refractory diabetic macular oedema after multiple anti-VEGF injections

Kim

Cho

Lee

et al. 2016

Eye

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Aims To investigate the effect of intravitreal dexamethasone implant (IVD) on central foveal thickness (CFT), choroidal thickness (CT) and its correlation with visual acuity in eyes with refractory diabetic macular oedema (DMO). Methods This was a retrospective interventional case-series. Thirty-five eyes of 35 patients were treated with a single injection of IVD because of refractory DMO with CFT over 300 μm, and persistent intraretinal and subretinal fluid despite of multiple intravitreal bevacizumab injections. Patients were followed-up for 6 months for the evaluation of CFT and subfoveal CT by spectral-domain optical coherence tomography. Results All eyes (mean age: 59.4 ± 12.35 years; 18 males, 17 females) had been previously treated with multiple bevacizumab injections and showed persistent DMO (mean number of injections 4.08 ± 2.98) The preoperative logMAR BCVA was 0.49 ± 0.24, which gradually improved to 0.46 ± 0.32 at 6 months (P = 0.652) and 26% gained two or more lines of Snellen visual acuity. At baseline, the mean CFT was 526.29 ± 123.48 μm, which significantly improved to 316.15 ± 100.09 μm at 3 months (Po0.001). However, CFT deteriorated to 457.07 ± 136.53 μm at 6 months (P = 0.051). Similarly, the mean preoperative subfoveal CT was 288.91 ± 36.47 μm and it decreased to 266.85 ± 30.93 μm at 3 months (Po0.01), but increased to 278.63 ± 32.55 μm at 6 months (P = 0.137). The reduction of CFT from baseline showed significant correlation with that of subfoveal CT at 3 months (P = 0.041) and at 6 months (P = 0.008). Conclusions In DMO refractory to multiple bevacizumab injections, IVD significantly reduced CFT and subfoveal CT, with BCVA improvement in one-fourth of the patients. The reduction of CFT showed significant correlation with reduction of subfoveal CT.

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Choroidal Thickness in Behcet's Uveitis: An Enhanced Depth Imaging-Optical Coherence Tomography and Its Association With Angiographic Changes

Cited by 137 publications

References 25 publications

The effect of topical anti-muscarinic agents on subfoveal choroidal thickness in healthy adults

The effect of topical anti-muscarinic agents on subfoveal choroidal thickness in healthy adults

Subfoveal choroidal thickness as a predictor of central serous chorioretinopathy

Effect of intravitreal dexamethasone implant on retinal and choroidal thickness in refractory diabetic macular oedema after multiple anti-VEGF injections

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