Choroidal observations in Vogt–Koyanagi–Harada disease using high-penetration optical coherence tomography

Nakai, Kei; Gomi, Fumi; Ikuno, Yasushi; Yasuno, Yoshiaki; Nouchi, T.; Ohguro, Nobuyuki; Nishida, Kohji

doi:10.1007/s00417-011-1910-7

Cited by 132 publications

(93 citation statements)

References 20 publications

(35 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In patients with acute VKH disease, EDI-OCT images clearly showed bilateral diffusely thickened choroids that decreased over time with corticosteroid treatment [4][5][6]. In the current case, we clearly visualized the full-thickness choroid except in the untreated phase and the decreasing choroidal thickness during tapering of oral prednisolone.…”

Section: Discussionsupporting

confidence: 49%

“…However, Nakai et al [6] reported that a SRD developed again in four eyes with anterior inflammation and the choroidal thickness again increased markedly. The choroid appears to be primarily affected in VKH disease initially; therefore, rebound choroidal thickening seen on EDI-OCT images could be regarded as recurrent VKH disease, as in the current case, despite no clinical evidence of recurrent ocular inflammation.…”

Section: Discussionmentioning

confidence: 98%

“…These images also showed choroidal thickening across the macular area (>600 μm at the subfovea), but it was difficult to precisely measure the choroidal thickness because the boundary between the choroid and sclera was unclear (Fig. 1d, e) [6]. The test for the human leukocyte antigen-DRB1*0405 haplotype was positive.…”

Section: Ishibazawa Et Almentioning

confidence: 98%

“…Enhanced-depth imaging optical coherence tomography (EDI-OCT) has provided new information about the overall choroidal thickness [3]. Increasing evidence shows that patients with acute VKH disease have marked choroidal thickening, possibly related to inflammatory infiltration and increased choroidal exudation [4][5][6]. In addition, the choroidal thickness decreases after high-dose corticosteroid treatment but increases again in recurrent VKH disease [5,6].…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Recurrent Vogt–Koyanagi–Harada disease with sensorineural hearing loss and choroidal thickening

et al. 2013

View full text Add to dashboard Cite

Purpose We report a case of Vogt-Koyanagi-Harada (VKH) disease that recurred with sensorineural hearing loss and choroidal thickening. MethodsWe measured the choroidal thickness using enhanced-depth imaging optical coherence tomography (EDI-OCT) in a patient with VKH during corticosteroid-tapering therapy.Results A 71-year-old man presented with fever, headache, and anorthopia associated with wavy choroidal folds and a serous retinal detachment (SRD). The EDI-OCT images showed choroidal thickening (> 600 μm at the subfovea), and he was diagnosed with VKH disease. After treatment with pulsed intravenous methylprednisolone, the choroidal folds and SRD resolved and the choroidal thickness decreased. About 6 months after subsequent treatment with an oral corticosteroid started, headache, tinnitus, and sensorineural hearing loss developed, and increased choroidal thickness was observed without other evidence of increased ocular inflammation. A high-dose corticosteroid was injected and tapered, and the sensorineural hearing loss improved immediately and the choroidal thickness decreased. Ishibazawa et al. 4Conclusions In the current case, sensorineural hearing loss occurred with recurrent VKH disease; however, there were no ocular inflammatory signs except for rebound choroidal thickening. Measuring the choroidal thickness using EDI-OCT can sensitively identify recurrent VKH disease.

show abstract

Section: Discussionsupporting

confidence: 49%

Section: Discussionmentioning

confidence: 98%

Section: Ishibazawa Et Almentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Recurrent Vogt–Koyanagi–Harada disease with sensorineural hearing loss and choroidal thickening

et al. 2013

View full text Add to dashboard Cite

show abstract

“…25 Several groups have described reversal of choroidal thickening, and even atrophy, in patients with VKH disease following treatment. [26][27][28][29][30] Hessen et al described a 58-year-old black woman who developed a painless 6 Â 7 mm scleral nodule underneath normal appearing conjunctiva with no clinical evidence of scleral inflammation. 21 At the time of biopsy, the lesion was found to arise from the sclera and to involve the insertion of the medial rectus muscle.…”

mentioning

confidence: 99%

Sarcoid Uveitis

Cunningham

Lowder

Miserocchi³

et al. 2014

Ocular Immunology and Inflammation

View full text Add to dashboard Cite

Choroidal Thickness in Patients With a History of Retinopathy of Prematurity

Shih

Wang

et al. 2013

JAMA Ophthalmol

View full text Add to dashboard Cite

The cause of reduced vision in patients with a history of retinopathy of prematurity (ROP) is not yet fully understood. The role of the choroid in ROP remains unknown and existing studies of choroidal thickness in patients with a history of ROP are limited. It might be helpful to understand the association of the choroid with ROP by measuring the choroidal thickness in patients with a history of ROP and correlating these findings with the visual outcome of these patients. OBJECTIVE To examine choroidal thickness by spectral-domain optical coherence tomography in children with a history of ROP and assess the impact of choroidal thickness on visual acuity. DESIGN A prospective cross-sectional analysis from August 2011 to September 2012. SETTING Institutional referral centers. PARTICIPANTS Children aged 6 to 14 years with a history of ROP were classified into the following 2 groups: patients with a history of threshold ROP and treatment with laser or cryotherapy (treated group) and those with regressed ROP who had not received any treatment (nontreated group). All of the patients had a normal-appearing posterior pole. INTERVENTION Examinations of visual acuity, refractive errors, and optical components and measurement of choroidal thickness. MAIN OUTCOMES AND MEASURES Best-corrected visual acuity, optical components, and optical coherence tomography findings. RESULTS In total, 49 patients were enrolled in the study. Patients in the treated group had a significantly thinner choroidal thickness than the patients in the nontreated group after adjusting for age, axial length, and spherical power. Choroidal thickness was found to be positively associated with spherical power and spherical equivalent and negatively associated with axial length and vitreous depth. In addition, a thin choroidal thickness was associated with a worse best-corrected visual acuity. CONCLUSIONS AND RELEVANCE Choroidal thickness is thinner in patients with threshold ROP compared with the patients with spontaneously regressed ROP. A thinner choroid is associated with worse vision in these patients. This study might imply the association of choroid circulation with ROP.

show abstract

Choroidal observations in Vogt–Koyanagi–Harada disease using high-penetration optical coherence tomography

Abstract: Significant choroidal thickness changes underlie VKH disease, which progress over time. Objective measurement of the choroidal thickness using HP-OCT may be useful for longitudinal evaluation of VKH activity.

Cited by 132 publications

References 20 publications

Recurrent Vogt–Koyanagi–Harada disease with sensorineural hearing loss and choroidal thickening

Recurrent Vogt–Koyanagi–Harada disease with sensorineural hearing loss and choroidal thickening

Sarcoid Uveitis

Choroidal Thickness in Patients With a History of Retinopathy of Prematurity

Contact Info

Product

Resources

About