2022
DOI: 10.1111/aos.15112
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Abstract: The pachychoroid disease spectrum (PDS) includes several chorioretinal diseases that share specific choroidal abnormalities. Although their pathophysiological basis is poorly understood, diseases that are part of the PDS have been hypothesized to be the result of venous congestion. Within the PDS, central serous chorioretinopathy is the most common condition associated with vision loss, due to an accumulation of subretinal fluid in the macula. Central serous chorioretinopathy is characterized by distinct risk … Show more

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Cited by 26 publications
(31 citation statements)
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“…Durch eine choroidale Anastomose kommt es zu einem Blutfluss von Arterie zu Vene unter Umgehung des intermediären Kapillarbettes. Dies kann zu einer venösen Überbelastung führen, was wiederum in einer Erweiterung und Hyperpermeabilität dieser Gefäße und folglicher Verdrängung der Choriokapillaris resultiert [12]. Merke Viele Autoren betrachten eine SCT von mehr als 300 µm als pathologisch [3,9].…”
Section: Merkeunclassified
“…Durch eine choroidale Anastomose kommt es zu einem Blutfluss von Arterie zu Vene unter Umgehung des intermediären Kapillarbettes. Dies kann zu einer venösen Überbelastung führen, was wiederum in einer Erweiterung und Hyperpermeabilität dieser Gefäße und folglicher Verdrängung der Choriokapillaris resultiert [12]. Merke Viele Autoren betrachten eine SCT von mehr als 300 µm als pathologisch [3,9].…”
Section: Merkeunclassified
“…The CSC pathophysiology remains incompletely understood, but clinical findings of dilated choroidal vessels, anastomoses, and vascular hyperpermeability point to a venous overload hypothesis [3,9], which has also been linked to a thicker sclera [10,11]. Exposure to corticosteroids is a strong risk factor for CSC [12].…”
Section: Introductionmentioning
confidence: 99%
“…Exposure to corticosteroids is a strong risk factor for CSC [12]. Male sex is another strong risk factor for CSC [9,13]. Schellevis et al [14] reported increased levels of steroid hormones that are considered precursors of testosterone in patients with CSC.…”
Section: Introductionmentioning
confidence: 99%
“…Increased cortisol levels, both due to exogenous and endogenous causes, are linked to the development of central serous chorioretinopathy (CSC) [ 5 , 6 ]. Developments in retinal and choroidal imaging, especially during the last decade, have revealed that CSC is linked to a thicker choroid, i.e., pachychoroid, and that this pachychoroid is seen in a spectrum of conditions, which appear to share both clinical nature and etiological findings [ 7 , 8 , 9 , 10 ]. It is hypothesized that pachychoroid reflects a choroidal venous overload, which is supported by angiographic evidence of choroidal vascular hyperpermeability, dilated veins, vortex venous anastomoses, and delayed filling of the choroidal veins [ 7 , 8 , 9 , 10 ].…”
Section: Introductionmentioning
confidence: 99%
“…Developments in retinal and choroidal imaging, especially during the last decade, have revealed that CSC is linked to a thicker choroid, i.e., pachychoroid, and that this pachychoroid is seen in a spectrum of conditions, which appear to share both clinical nature and etiological findings [ 7 , 8 , 9 , 10 ]. It is hypothesized that pachychoroid reflects a choroidal venous overload, which is supported by angiographic evidence of choroidal vascular hyperpermeability, dilated veins, vortex venous anastomoses, and delayed filling of the choroidal veins [ 7 , 8 , 9 , 10 ]. These circumstances are hypothesized to explain a disease progression of first a gradual development of a pachychoroid phenotype; followed by a pachychoroid pigment epitheliopathy (PPE), i.e., pigment epithelium detachment (PED) without any subretinal fluid or intraretinal fluid; followed by CSC; and CSC complicated by neovascularizations, e.g., seen as polypoidal choroidal vasculopathy (PCV)/aneurysmal type 1 neovascularization [ 7 , 8 , 9 , 10 ].…”
Section: Introductionmentioning
confidence: 99%