Chondromyxoid fibroma of the nasal cavity with an interstitial insertion between chromosomes 6 and 19

Smith, Cristina A.; Magenis, R. Ellen; Himoe, Eleanor; Smith, Cheree; Mansoor, Atiya

doi:10.1016/j.cancergencyto.2006.05.018

Cited by 21 publications

(10 citation statements)

References 6 publications

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“…In particular, rearrangements of the chromosome 6 long arm were most frequent, with four of the cases having pericentric inversion inv(6)(p25q13). 23 Importantly, chromosome 6 has been implicated in normal cartilaginous development, carrying genes BMP6 (bone morphogenetic protein 6), COL9A1 (collagen type 9 α 1), COL10A1 (collagen type 10 α 1), and IGF2 (insulin-like growth factor 2). Additionally, supporting the possible genetic propensity for CMF, our literature review revealed three cases of congenital CMF presenting in newborns.…”

Section: Discussionmentioning

confidence: 99%

Chondromyxoid Fibroma of the Skull Base and Calvarium: Surgical Management and Literature Review

Yaghi

DeMonte

2016

J Neurol Surg Rep

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Chondromyxoid fibroma (CMF) is an exceedingly rare tumor that represents less than 1% of all primary bone neoplasms. Occurrence in the facial and cranial bones is extremely rare and frequently misdiagnosed. Case Reports We report two cases of CMF, one in the sphenoclival skull base and the other involving the parietal bone in two young female patients. Excision was performed in both cases. Presenting symptoms, treatment, and follow-up are reported. Methods A retrospective review of the literature on cranial CMF was performed. The location, demographics, presenting symptoms, and treatment of all calvarial and skull base CMF cases published since 1990 are summarized. Discussion In our literature review, we found 67 published cases of cranial CMF. Mean age of all calvarial and skull base CMFs at diagnosis was 38.2 years old. Of the cases affecting the cranium, the sinonasal structures were most commonly involved. To our knowledge we report only the second case of CMF involving the parietal bone published in an English-language journal. Total resection is the best treatment, and should be the goal of surgical intervention. Curettage results in high recurrence rates. Radiotherapy in the setting of subtotal resection or recurrence cannot be definitively recommended and needs further investigation.

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Section: Discussionmentioning

confidence: 99%

Chondromyxoid Fibroma of the Skull Base and Calvarium: Surgical Management and Literature Review

Yaghi

DeMonte

2016

J Neurol Surg Rep

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“…[23] It has been suggested that several distinct breakpoints on chromosome 6 are nonrandomly involved in CMF. The other cytogenetic case report on a nasal cavity CMF has shown insertion between chromosome 6 and 19 in a nasal CMF [24]. …”

Section: Discussionmentioning

confidence: 99%

Chondromyxoid Fibroma of Sphenoid Sinus with Unusual Calcifications: Case Report with Literature Review

Morris

Rihani

Lebowitz

et al. 2009

Head and Neck Pathol

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Chondromyxoid fibroma (CMF) is a rare benign primary tumor which usually affects the metaphyses of the long bone of the lower extremities in childhood and young adults. Rarely, CMF occurs in the skull base and parasinuses, which may be difficult to distinguish from chondrosarcoma or chordoma and other tumors in the head. It is composed of chondroid, myxoid, and fibrous tissue growth in a lobular pattern, infrequently with calcifications. We report one case of CMF involving the sphenoid sinus mimicking a chondrosarcoma. The tumor mass showed calcifications on images and histology.

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“…This may be due to the fact that chromosome 6 is location for several genes responsible for normal development of cartilage. 16 Abnormalities reported include pericentric inversion of chromosome 6 [inv (6) (p25q13)] in CMF of long bone 17 or insertion between chromosomes 6 and 19 in nasal CMF. 16…”

Section: Discussionmentioning

confidence: 99%

Chondromyxoid Fibroma of the Anterior Skull Base Invading the Orbit in a Pediatric Patient: Case Report and Review of the Literature

Khalatbari¹,

Hamidi²,

Moharamzad³

2012

Neuropediatrics

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Chondromyxoid fibroma (CMF) is a rare bone tumor of cartilaginous derivation representing less than 1% of all benign bone neoplasms. It is a slow-growing, locally destructive tumor that usually affects the metaphyseal region of long bones of patients in their second or third decade of life. Involvement of the skull base and orbit is extremely rare. We present the first case of histopathology-proven CMF originating in the greater sphenoid wing and extending into the orbit in a 14-year-old boy. He complained of pain and swelling of his left lateral orbit for 4 months and had 3-mm nonaxial proptosis. Magnetic resonance imaging of the orbit revealed a well-defined lesion in the lateral wall of the left orbit, hypointense on T1-weighted images, and heterogenous hyperintense on T2-weighted images and enhanced after contrast media injection. Through a left semicoronal skin incision, the mass was removed totally and the lateral orbital wall was reconstructed. The clinical manifestations, imaging findings, and surgical treatment of the lesion are discussed with a review of the literature.

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Chondromyxoid fibroma of the nasal cavity with an interstitial insertion between chromosomes 6 and 19

Cited by 21 publications

References 6 publications

Chondromyxoid Fibroma of the Skull Base and Calvarium: Surgical Management and Literature Review

Chondromyxoid Fibroma of the Skull Base and Calvarium: Surgical Management and Literature Review

Chondromyxoid Fibroma of Sphenoid Sinus with Unusual Calcifications: Case Report with Literature Review

Chondromyxoid Fibroma of the Anterior Skull Base Invading the Orbit in a Pediatric Patient: Case Report and Review of the Literature

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