Chondromyxoid Fibroma of the Ethmoid Sinus Complicated by a Brain Abscess - A Case Report and Literature Review -

Won, Kyu Yeoun; Lee, Juhie; Kim, Youn Wha; Kim, Eui Jong; Kim, Sung Wan; Park, Yong-Koo

doi:10.4132/koreanjpathol.2010.44.5.547

Cited by 3 publications

(3 citation statements)

References 13 publications

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“…Histologically, chondrosarcoma reveals hypercellularity without zonal architecture. The CMF also differs from chondrosarcoma, with the latter usually producing a large amount of well-differentiated hyaline cartilage and entrapping the pre-existing lamellar bone trabeculae with permeation [11].…”

Section: Discussionmentioning

confidence: 99%

Juxtacortical chondromyxoid fibroma in the small bones: two cases with unusual location and a literature review

Chung

2022

J Pathol Transl Med

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Chondromyxoid fibroma (CMF) is a rare, benign neoplasm of the bones, mostly affecting people in the second or third decade of life, with a slight male predominance. Long bones, especially the proximal tibia, are the most frequently affected sites, followed by the distal femur, pelvis, and small bones of acral sites [1,2]. The typical CMF eccentrically arises in the medulla of the metaphysis, with sharply circumscribed margins. Infrequent cases of juxtacortical subtypes have been documented in long bones, but only three of the short tubular bones have been reported in the English literature (Table 1). Here we present two new cases of juxtacortical CMF in the hand and foot, respectively. CASE REPORTCase 1A 43-year-old man presented with a swelling on the dorsum of the right foot for more than one year. He complained of intermittent pain for a few months. Plain films demonstrated a wellmarginated osteolytic lesion on the second metatarsal bone of the right foot (Fig. 1A). Magnetic resonance imaging (MRI) showed a 2 × 1.7 cm intracortical mass with expansile growth (Fig. 1B). Medullary bone was partially involved. T1-weighted images revealed an intermediate signal, while T2-weighted images showed a heterogeneous signal with some areas of high intensity. Preoperative diagnosis was a benign bone tumor such as simple bone cyst, and curettage with bone graft was performed.Histological examination of the lesion showed a lobular architecture on the low-power view (Fig. 2A). Lobules demonstrated hypocellular centers with hypercellular peripheries. Center of the lobules consisted of stellate or spindle-shaped cells with eosinophilic cytoplasmic processes in a myxoid background (Fig. 2B). Cellular areas in the periphery contained round cells with enlarged, hyperchromatic, and pleomorphic nuclei (Fig. 2C). Vacuolization was observed. The nucleocytoplasmic ratio of these cells, however, was low, and no mitosis was found, which implied degeneration rather than malignancy. Overall histologic features rendered a diagnosis of chondromyxoid fibroma. There has been no recurrence for seven months after the surgery.

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Section: Discussionmentioning

confidence: 99%

Juxtacortical chondromyxoid fibroma in the small bones: two cases with unusual location and a literature review

Chung

2022

J Pathol Transl Med

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“…However, CMF in craniofacial region has been rarely reported, about 2%. [ 5 , 6 ] According to the report of Won et al, [ 7 ] the morbidity of CMF in craniofacial region was near to 5.4%; it often involved maxilla and mandible, but the morbidity in mandible was 76%, evidently higher than the 24% in maxilla, and there was no significant difference in sex. [ 4 ] This tumor can be cured after local excochleation, but the recurrence rate is high if the surgical treatment is improper.…”

Section: Introductionmentioning

confidence: 99%

Treatment of cryotherapy and orthotopic transplantation following chondromyxoid fibroma of zygomatic bone

Zhu¹,

Yang²,

Xu³

et al. 2018

Medicine

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Introduction:Chondromyxoid fibrotherma (CMF) is a rare benign cartilage tumor that occurs more frequently in young males at the age of 20 to 30. It occurs more frequently on long bones, but rarely involves craniofacial bones.Case presentation:This study mainly introduced a 30-year-old male with CMF of zygomatic bone. Single tumor excochleation was conducted initially. However, CMF reoccurred, and then the following steps were adopted: firstly, the tumor was extensively excised; secondly, in vitro tumor excochleation was conducted; thirdly, the excised tumor bone was placed in liquid nitrogen for 3 cycles of cryoablation; finally, the orthotopic transplantation was performed to reconstruct the zygomatic appearance, with satisfactory follow-up efficacy obtained.Conclusions:Orthotopic transplantation after tumorectomy and cryopreservation of tumor bone in liquid nitrogen could lead to excellent therapeutic efficacy and deserves to be widely applied in clinical practice in the treatment of a male patient with CMF of zygomatic bone, because it not only radically eliminates the tumor and kills tumor cells, but also provides bony skeleton for the growth of new bone, thus greatly promoting postoperative aesthetic degree and reducing the occurrence rates of complications.

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“…[ 3 ] This benign neoplasm occurs most frequently in young adults and it is found in numerous anatomic locations, including long bones, flat bones and craniofacial bones. [ 2 3 ] The craniofacial region bones tumors are extremely rare, approximately 2% of the cases,[ 3 4 ] nearly 5.4% according to Won et al ., 2010[ 5 ] and they often involve the jaw and maxilla,[ 4 ] with a higher incidence in the mandible (76%) than in the maxilla (24%) and an equal sex distribution. [ 6 ]…”

Section: Introductionmentioning

confidence: 99%

Chondromyxoid fibroma of the mandible: Case report and review of the literature

Fomete

Adeosun

Awelimobor

et al. 2014

Ann Maxillofac Surg

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Introduction:Chondromyxofibroma (CMF) is exceedingly rare, accounting for 0.5% of the 10,065 bone tumors categorized by Unni and Inwards and 1.6% of their catalog of benign bone tumors. Only 2 of the 50 chondromyxoid fibromas included in their study occurred in the skull. Chondromyxoid fibroma of the maxillofacial region is typically seen in patients in the 2nd-3rd decade of life with slight female predominance. It is more commonly seen in the maxilla and is unusual in the sphenoid and ethmoid sinuses. The tumor is composed of hypocellular chondroid or myxochondroid tissue with multinucleated giant cells.Case Report:A 30 year old Nigerian house wife was seen at the Oral and Maxillofacial clinic of the Dental and Maxillofacial Department of the Federal Medical Centre Lokoja with a 4 year history of Rt mandibular swelling which was initially slow growing and painless and difficulty in eating. The whole lesion was removed and result confirmed the previous biopsy of chondromyxofbroma of the jaw.Conclusion:Patients with CMF need close monitoring due to high rate of recurrence with cases of malignant transformation at rate of 1-2%, and this seems to have occurred following irradiation.

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Chondromyxoid Fibroma of the Ethmoid Sinus Complicated by a Brain Abscess - A Case Report and Literature Review -

Cited by 3 publications

References 13 publications

Juxtacortical chondromyxoid fibroma in the small bones: two cases with unusual location and a literature review

Juxtacortical chondromyxoid fibroma in the small bones: two cases with unusual location and a literature review

Treatment of cryotherapy and orthotopic transplantation following chondromyxoid fibroma of zygomatic bone

Chondromyxoid fibroma of the mandible: Case report and review of the literature

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