Chondroma of the Larynx

Laryngeal chondromas: Current knowledge and future directions

“…Although LC is mainly described during the fifth decade of life, 2 it can also occur in the pediatric population with less than 10 cases reported, including three in neonates. 19 , 20 , 21 , 22 The sex ratio of LC varies considerably among different studies, ranging from 10:1 to 2:1. 1 , 2 , 4 , 9 , 13 , 23 , 24 In our study, we observed that males were affected 2.8 times more frequently than females.…”

“…LC is most commonly found in the cricoid cartilage followed by the thyroid cartilage, with the arytenoids and epiglottis cartilages being the least common locations. 1 , 4 , 7 , 15 , 20 Further, within the cricoid cartilage, the internal surface of the posterior lamina is the most prevalent location for LC. 13 , 30 , 31 The slow‐growing nature and diverse locations of LC result in a range of presentations, from asymptomatic patients to airway obstruction cases with a strong predominance of long‐lasting symptoms before any clinical consultation.…”

“…This process typically occurs during adulthood, but it is hypothesized that disordered ossification associated with pluripotent mesenchymal stem cells may contribute to the development of chondromas and chondrosarcomas 23 . To date, pediatric cases do not have an established etiology 20 …”

“…The frequency of localization reported in the literature is supported by our study. LC is most commonly found in the cricoid cartilage followed by the thyroid cartilage, with the arytenoids and epiglottis cartilages being the least common locations 1,4,7,15,20 . Further, within the cricoid cartilage, the internal surface of the posterior lamina is the most prevalent location for LC 13,30,31 .…”

“…23 To date, pediatric cases do not have an established etiology. 20 The development of LC is not currently associated with any identifiable risk factors. However, some studies have suggested that a history of radiotherapy and Teflon injection may be predisposing factors for malignant cartilaginous tumors.…”