Chondroblastoma‐like osteosarcoma

Martin, Karrie; Firestone, Daniel E.; McGarry, Sean V.; Dorfman, Howard D.; Kazmi, Syed A. Jaffar

doi:10.1111/pin.12182

Cited by 5 publications

(14 citation statements)

References 7 publications

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“…We also report here the H3F3 mutational status of a tumor combining typical areas of chondroblastoma and areas of high-grade conventional osteosarcoma, with a sudden transition between the two components. In view of these tumors, very few cases of which have been described in the literature, 16,17 the diagnosis of malignant chondroblastoma rather than chondroblastoma-like osteosarcoma could be raised. This sample exhibited a rare mutation of H3F3A (K37M), never to our knowledge described in the other giant cell-rich tumors.…”

Section: Discussionmentioning

confidence: 99%

H3F3 mutation status of giant cell tumors of the bone, chondroblastomas and their mimics: a combined high resolution melting and pyrosequencing approach

et al. 2017

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Behjati et al recently described recurrent mutations of H3F3 genes in giant cell tumors of the bone and chondroblastomas. Both these entities belong to the spectrum of giant cell-rich bone lesions, often presenting a diagnostic challenge for the pathologist. Our aim was to investigate the value of searching for H3F3 mutations in the diagnosis of giant cell tumors of the bone and giant cell-rich chondroblastomas. Two hundred eighty-one bone lesion samples, including 170 giant cell tumors of the bone, 26 chondroblastomas and 85 other giant cell-rich and/or epiphyseal tumors, were analyzed. Mutation status was determined using first high resolution melting screening and then mutation profiling pyrosequencing. Mutational status was compared with clinical data and, for giant cell tumors of the bone, with p63 immunostaining status. As histone methylation changes have been reported in association with H3F3 mutations, the methylation status of lysine 37 was investigated. H3F3A and H3F3B were found in 85% of giant cell tumors of the bone and 88% of chondroblastomas. In addition to the major G35W mutation, we found two rare H3F3A mutations: one G35R and one G35V. Among the other tumors studied, we only found H3F3A gene mutations in two cases of 'dedifferentiated chondrosarcoma mimicking giant cell tumor of the bone'. A H3F3B mutation was also observed in one case of dedifferentiated chondroblastoma. P63 expression in giant cell tumors of the bone seems to be associated with H3F3 gene mutations (P=0.004). H3F3 mutations did not correlate with clinical data, outcome or methylation changes in Lysin 37. In conclusion, H3F3 mutations are sensitive and specific markers of giant cell tumors of the bone and chondroblastomas. High resolution melting and pyrosequencing procedures are high-performance tools in this context. Determination of H3F3 mutation will allow reclassification of some entities belonging to the spectrum of giant cell-rich lesions.

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Section: Discussionmentioning

confidence: 99%

H3F3 mutation status of giant cell tumors of the bone, chondroblastomas and their mimics: a combined high resolution melting and pyrosequencing approach

et al. 2017

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“…In long bones, the tumor was located in the metadiaphysis (6 cases) and in the epiphysis (2 cases). [4][5][6][7][8][9] Radiographs were available for 19 of 22 cases (86%). Sixteen of the 22 cases (72%) were diagnosed as malignant or worrisome for malignancy, 2 (9%) were interpreted as benign lesions, and 1 (4.5%) had an equivocal diagnosis.…”

Section: Resultsmentioning

confidence: 99%

“…As such, only one case had detailed gross description, which showed a tan, glistening mass replacing the bone and infiltrating into soft tissue. 7 Treatment history was available for 3 of 22 cases (14%): 1 was treated with resection, 1 with curettage, and 1 with curettage and resection. Follow-up, ranging from 6 months to 12 years, was available for 13 of the 22 patients (59%).…”

Section: Resultsmentioning

confidence: 99%

“…The radiologic differential diagnosis includes CBL, giant cell tumor, aneurysmal bone cyst, and chondrosarcoma, among others. 4,5,[7][8][9] Histologically, CBL-like OS is characterized by cellular areas resembling CBL and abnormal osteoid deposition with destruction of the nonneoplastic bone. 6 The tumor shows an infiltrative growth pattern composed of small cells showing ovoid, folded, or grooved nuclei with pale eosinophilic cytoplasm, resembling the cells observed in CBL (Figures 2 through 4).…”

Section: Discussionmentioning

confidence: 99%

“…1 A very rare variant is chondroblastoma (CBL)-like OS, 4 with 22 cases described in the literature. [4][5][6][7][8][9] It is characterized by cellular areas resembling CBL and abnormal osteoid deposition with destruction of the bone. 6…”

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Chondroblastoma-like Osteosarcoma

Hmada

Bernieh

Morris

et al. 2019

Archives of Pathology &Amp; Laboratory Medicine

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Context.— Chondroblastoma-like osteosarcoma is an exceedingly rare variant of osteosarcoma, with 22 cases reported in the English-language literature. The tumor is slightly more common in males, with a broad age range (from childhood to elderly). The most commonly involved bones are the metatarsus and tibia, followed by the femur. Most tumors have malignant or worrisome radiographic findings. Prognosis is variable, depending on the presence or absence of lung metastases, local recurrence, and probably tumor location. Histologically, chondroblastoma-like osteosarcoma is characterized by monotonous, minimally to moderately atypical rounded cells with ovoid nuclei resembling chondroblastoma, and abnormal osteoid deposition with destruction of the bone. Objective.— To review the clinical, radiographic, and histopathologic features of chondroblastoma-like osteosarcoma. Data Sources.— PubMed-published chondroblastoma-like osteosarcoma cases in the English-language literature. Conclusions.— Although exceedingly rare, chondroblastoma-like osteosarcoma should be considered in the differential diagnosis of chondroblastoma, especially in the presence of radiologic findings suggestive of an aggressive lesion.

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Aggressive curettage of a chondroblastoma-like osteosarcoma of the proximal end of the tibia. A case report with seven-year follow-up

et al. 2018

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A chondroblastoma-like osteosarcoma (CLO) in the proximal epiphysis and metaphysis of the tibia in a 30-year-old male is presented. With a wrong diagnosis of chondroblastoma, an aggressive curettage was performed. Later, the patient refused en-bloc resection. Seven years after surgery, there has been no local recurrence, and the patient is living an ordinary and active life. CLO is a very uncommon and controversial histologic subtype of osteosarcoma that can be misdiagnosed as chondroblastoma and therefore incorrectly treated. However, aggressive curettage with its functional advantages could be a reasonable option in selected cases.

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Chondroblastoma‐like osteosarcoma

Cited by 5 publications

References 7 publications

H3F3 mutation status of giant cell tumors of the bone, chondroblastomas and their mimics: a combined high resolution melting and pyrosequencing approach

H3F3 mutation status of giant cell tumors of the bone, chondroblastomas and their mimics: a combined high resolution melting and pyrosequencing approach

Chondroblastoma-like Osteosarcoma

Aggressive curettage of a chondroblastoma-like osteosarcoma of the proximal end of the tibia. A case report with seven-year follow-up

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