Cholinergic, dopaminergic and insulin receptors gene expression in the cerebellum of streptozotocin-induced diabetic rats: Functional regulation with Vitamin D3 supplementation

Peeyush, Kumar T.; Sadasivam, Balakrishnan; Antony, Sherin; Anju, T. R.; Paul, Jes; Paulose, C S

doi:10.1016/j.pbb.2010.01.008

Cited by 37 publications

(18 citation statements)

References 81 publications

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“…Cells transfected with si-InR, si-IGF-1R, or si-IGF-2R each had reduced levels of ChAT, corresponding with an earlier finding that ChAT is regulated by insulin and IGF (Soscia, Tong et al 2006). ChAT generates acetylcholine, which has an important role in cognitive and motor functions (Dineley-Miller and Patrick 1992;Deutsch, Urbano et al 2010;Peeyush, Savitha et al 2010;Pepeu and Giovannini 2010). Since inhibition of neuronal insulin, IGF-1, or IGF-2 receptors leads to deficits in ChAT expression, impairments in cognition can be attributed to CNS insulin/IGF resistance (Rivera, Goldin et al 2005; LesterColl, Rivera et al 2006;Soscia, Tong et al 2006 Lyn-Cook, Lawton et al 2009;Tong, Longato et al 2010).…”

Section: Discussionmentioning

confidence: 99%

Insulin Resistance, Cognitive Impairment and Neurodegeneration: Roles of Nitrosamine Exposure, Diet and Lifestyles

Monte¹,

Tong²,

Wands³

2011

Alzheimer's Disease Pathogenesis-Core Concepts, Shifting Paradigms and Therapeutic Targets

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Section: Discussionmentioning

confidence: 99%

Insulin Resistance, Cognitive Impairment and Neurodegeneration: Roles of Nitrosamine Exposure, Diet and Lifestyles

Monte¹,

Tong²,

Wands³

2011

Alzheimer's Disease Pathogenesis-Core Concepts, Shifting Paradigms and Therapeutic Targets

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“…Speer et al [31] reported that patients with diabetes and obesity with the BB genotype of the BsmI allele in the VDR gene presented higher levels of postprandial serum C-peptide, which points to a possible role in the pathogenesis of type 2 diabetes. It has also been reported that in subjects with 25 …”

Section: Vitamin D Receptor Polymorphismsmentioning

confidence: 80%

“…To become biologically active, vitamin D needs two successive hydroxylations in the liver (at carbon 25) . This is the biologically active form of vitamin D [7] ( Fig.…”

Section: Metabolism Of Vitamin Dmentioning

confidence: 99%

“…The Possible mechanism is likely to be the indirect effect of vitamin D. Vitamin D contributes to normalization of extracellular calcium ensuring normal intracellular calcium pool as elevated intracellular calcium impairs insulin receptor phosphorylation leading to impaired insulin signal transduction and decreased GLUT-4 activity. Peeyush et al [25] examined the effect of vitamin D supplementation on preventing the altered expression of GLUT-3 in STZ-induced diabetic rats leading to imbalanced glucose transport in the neurons of cerebellum. They observed that treatment with vitamin D and insulin, stabilized the glucose transport mechanism mediated through GLUT-3 in the cerebellum.…”

Section: Vitamin D and Glucose Transportmentioning

confidence: 99%

“…A study by K.T. Peeyush [25] reported the altered expression of cholinergic and dopaminergic receptors in the central nervous system of STZ-induced diabetic rats. They further suggested that the altered expression of these receptors was brought back to control by the treatment with vitamin D. A small, clinical study of 51 patients with type 2 diabetes (37 female) evaluated neuropathic complaints such as pain, burning, tingling, numbness, and throbbing sensations.…”

Section: Vitamin D and Complications Of Diabetesmentioning

confidence: 99%

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Role of Vitamin D in Diabetes

Seshadri

2011

J Endocrinol Metab

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The role of vitamin D in the pathogenesis and prevention of diabetes has sparked widespread interest. Vitamin D receptors are present in both pancreatic beta-cells and immune cells. Beside its classical role as the major regulator for calcium absorption, vitamin D mediates the activity of beta-cell calcium-dependent endopeptidases promotes conversion of proinsulin to insulin and increases insulin output. In peripheral insulin target tissues, vitamin D enhances insulin action via regulation of the calcium pool. Vitamin D also acts as a potent immunosuppressor. It tends to down-regulate the transcription of various proinflammatory cytokine genes like Interleukin-2, Interlukin-12, and Tumor Necrosis Factor-α. It promotes the induction of regulatory T-lymphocytes, the production of antiinflammatory cytokines and protects beta-cell from destruction. Vitamin D deficiency predisposes to type 1 diabetes in animal models and in humans. It is probable that a similar relationship exists for type 2 diabetes. Vitamin D deficiency impairs insulin secretion and induces glucose intolerance. Several vitamin D related genes are associated with different pathogenetic traits of the disease. Vitamin D supplementation has shown to reduce the risk of developing type 1 diabetes. Vitamin D has also been shown to reduce the risk of diabetes associated complications. Prospective clinical studies on vitamin D are required to firmly establish the role of vitamin D in the prevention and management of diabetes.

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Effect of vitamin D₃on behavioural and biochemical parameters in diabetes type 1‐induced rats

Calgaroto

Thomé

Costa

et al. 2014

Cell Biochemistry & Function

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Diabetes is associated with long-term complications in the brain and reduced cognitive ability. Vitamin D3 (VD3 ) appears to be involved in the amelioration of hyperglycaemia in streptozotocin (STZ)-induced diabetic rats. Our aim was to analyse the potential of VD3 in avoiding brain damage through evaluation of acetylcholinesterase (AChE), Na(+) K(+) -adenosine triphosphatase (ATPase) and delta aminolevulinate dehydratase (δ-ALA-D) activities and thiobarbituric acid reactive substance (TBARS) levels from cerebral cortex, as well as memory in STZ-induced diabetic rats. Animals were divided into eight groups (n = 5): control/saline, control/metformin (Metf), control/VD3 , control/Metf + VD3 , diabetic/saline, diabetic/Metf, diabetic/VD3 and diabetic/Metf + VD3 . Thirty days after treatment, animals were submitted to contextual fear-conditioning and open-field behavioural tests, after which they were sacrificed and the cerebral cortex was dissected. Our results demonstrate a significant memory deficit, an increase in AChE activity and TBARS levels and a decrease in δ-ALA-D and Na(+) K(+) -ATPase activities in diabetic rats when compared with the controls. Treatment of diabetic rats with Metf and VD3 prevented the increase in AChE activity when compared with the diabetic/saline group. In treated diabetic rats, the decrease in Na(+) K(+) -ATPase was reverted when compared with non-treated rats, but the increase in δ-ALA-D activity was not. VD3 prevented diabetes-induced TBARS level and improved memory. Our results show that VD3 can avoid cognitive deficit through prevention of changes in important enzymes such as Na(+) K(+) -ATPase and AChE in cerebral cortex in type 1 diabetic rats.

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Cholinergic, dopaminergic and insulin receptors gene expression in the cerebellum of streptozotocin-induced diabetic rats: Functional regulation with Vitamin D3 supplementation

Cited by 37 publications

References 81 publications

Insulin Resistance, Cognitive Impairment and Neurodegeneration: Roles of Nitrosamine Exposure, Diet and Lifestyles

Insulin Resistance, Cognitive Impairment and Neurodegeneration: Roles of Nitrosamine Exposure, Diet and Lifestyles

Role of Vitamin D in Diabetes

Effect of vitamin D₃on behavioural and biochemical parameters in diabetes type 1‐induced rats

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Cholinergic, dopaminergic and insulin receptors gene expression in the cerebellum of streptozotocin-induced diabetic rats: Functional regulation with Vitamin D3 supplementation

Cited by 37 publications

References 81 publications

Insulin Resistance, Cognitive Impairment and Neurodegeneration: Roles of Nitrosamine Exposure, Diet and Lifestyles

Insulin Resistance, Cognitive Impairment and Neurodegeneration: Roles of Nitrosamine Exposure, Diet and Lifestyles

Role of Vitamin D in Diabetes

Effect of vitamin D3on behavioural and biochemical parameters in diabetes type 1‐induced rats

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Product

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Effect of vitamin D₃on behavioural and biochemical parameters in diabetes type 1‐induced rats