Choline and amino acid based biocompatible ionic liquid mediated transdermal delivery of the sparingly soluble drug acyclovir

Islam, Rafiqul; Chowdhury, Raihan; Wakabayashi, Rie; Tahara, Yoshiro; Kamiya, Noriho; Moniruzzaman, Muhammad; Goto, Masahiro

doi:10.1016/j.ijpharm.2020.119335

Cited by 63 publications

(58 citation statements)

References 52 publications

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“…Finally, the treated skins were processed according to our previous report [27] to estimate the topical drug delivery content (penetrated into the skin). The concentration of ACV was determined using HPLC with a Shiseido CAPCELL PAK C18 MG (4.6 mm × 250 mm) column using the United States Pharmacopeia (USP) method according to a previous report [28], where the mobile phase was 0.02 M glacial acetic acid with elution at a flow rate 1.5 mL/min, and the injected volume of sample was 100 µL. The concentration range of the standard curves was 0-25 µg/mL, and the squared correlation coefficient of the standard curve was more than 0.99 (R 2 > 0.99).…”

Section: Skin Permeation Studiesmentioning

confidence: 99%

“…Nonetheless, ACV was solubilized state in IL, but as it is hydrophilic in nature, IL alone could not deliver ACV due to of the strong hydrophobic barrier functions of the skin [9]. On the other hand, though IPM, S/Comix/IPM, and W/O MEs disrupt the barrier function as they contain IPM, ACV could not permeate across the skin from these formulations because ACV was suspended in these systems, which probably obstructed the access of ACV to the skin [9,28].…”

Section: Skin Permeation Studiesmentioning

confidence: 99%

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Ionic Liquid-In-Oil Microemulsions Prepared with Biocompatible Choline Carboxylic Acids for Improving the Transdermal Delivery of a Sparingly Soluble Drug

et al. 2020

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The transdermal delivery of sparingly soluble drugs is challenging due to of the need for a drug carrier. In the past few decades, ionic liquid (IL)-in-oil microemulsions (IL/O MEs) have been developed as potential carriers. By focusing on biocompatibility, we report on an IL/O ME that is designed to enhance the solubility and transdermal delivery of the sparingly soluble drug, acyclovir. The prepared MEs were composed of a hydrophilic IL (choline formate, choline lactate, or choline propionate) as the non-aqueous polar phase and a surface-active IL (choline oleate) as the surfactant in combination with sorbitan laurate in a continuous oil phase. The selected ILs were all biologically active ions. Optimized pseudo ternary phase diagrams indicated the MEs formed thermodynamically stable, spherically shaped, and nano-sized (<100 nm) droplets. An in vitro drug permeation study, using pig skin, showed the significantly enhanced permeation of acyclovir using the ME. A Fourier transform infrared spectroscopy study showed a reduction of the skin barrier function with the ME. Finally, a skin irritation study showed a high cell survival rate (>90%) with the ME compared with Dulbecco’s phosphate-buffered saline, indicates the biocompatibility of the ME. Therefore, we conclude that IL/O ME may be a promising nano-carrier for the transdermal delivery of sparingly soluble drugs.

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Section: Skin Permeation Studiesmentioning

confidence: 99%

Section: Skin Permeation Studiesmentioning

confidence: 99%

Ionic Liquid-In-Oil Microemulsions Prepared with Biocompatible Choline Carboxylic Acids for Improving the Transdermal Delivery of a Sparingly Soluble Drug

et al. 2020

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“…Work out of the same lab was not only able to improve upon the solubility of acyclovir using cholinium amino acid ILs but also allowed for transdermal delivery of the drug. [ 35 ] The use of ammonium and phosphonium chlorides showed enhancements of 60‐ to 120‐fold over aqueous solutions alone, and the use of imidazolium thiocyanate and dicyanamide demonstrated that both the cation and anion can operate synergistically to mediate interactions between the organic molecule and the aqueous solution, thus increasing the overall solubility. [ 36 ] Cholinium amino acid ILs were used to solubilize and stabilize paclitaxel, sterically and ionically, preventing the drug molecules from aggregating for 3 months.…”

Section: Biomedical Applicationsmentioning

confidence: 99%

Recent Advances in Ionic Liquids in Biomedicine

2021

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The use of ionic liquids and deep eutectic solvents in biomedical applications has grown dramatically in recent years due to their unique properties and their inherent tunability. This review will introduce ionic liquids and deep eutectics and discuss their biomedical applications, namely solubilization of drugs, creation of active pharmaceutical ingredients, delivery of pharmaceuticals through biological barriers, stabilization of proteins and other nucleic acids, antibacterial agents, and development of new biosensors. Current challenges and future outlooks are discussed, including biocompatibility, the potential impact of the presence of impurities, and the importance of understanding the microscopic interactions in ionic liquids in order to design task-specific solvents.

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“…Hence, Islam et al have recently reported the preparation of “ILs-in-oil” microemulsions (MEs) by combining hydrophilic choline-based ILs (“water”-like) with a mixture of the SAIL choline oleate and sorbitan laurate (“oil” phase), which allowed enhanced permeation of acyclovir through pig skin while showing no significant skin irritation [ 147 ]. The same authors have also investigated ternary systems comprising ethanol, isopropyl myristate, and choline/amino acid-based ILs, also with encouraging results for solubilization and skin permeation of acyclovir [ 148 ].…”

Section: Ionic Liquid-based Approaches In Dermal and Transdermal Drug Deliverymentioning

confidence: 99%

The Emerging Role of Ionic Liquid-Based Approaches for Enhanced Skin Permeation of Bioactive Molecules: A Snapshot of the Past Couple of Years

Gomes

Aguiar

Ferraz

et al. 2021

IJMS

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Topical and transdermal delivery systems are of undeniable significance and ubiquity in healthcare, to facilitate the delivery of active pharmaceutical ingredients, respectively, onto or across the skin to enter systemic circulation. From ancient ointments and potions to modern micro/nanotechnological devices, a variety of approaches has been explored over the ages to improve the skin permeation of diverse medicines and cosmetics. Amongst the latest investigational dermal permeation enhancers, ionic liquids have been gaining momentum, and recent years have been prolific in this regard. As such, this review offers an outline of current methods for enhancing percutaneous permeation, highlighting selected reports where ionic liquid-based approaches have been investigated for this purpose. Future perspectives on use of ionic liquids for topical delivery of bioactive peptides are also presented.

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Choline and amino acid based biocompatible ionic liquid mediated transdermal delivery of the sparingly soluble drug acyclovir

Cited by 63 publications

References 52 publications

Ionic Liquid-In-Oil Microemulsions Prepared with Biocompatible Choline Carboxylic Acids for Improving the Transdermal Delivery of a Sparingly Soluble Drug

Ionic Liquid-In-Oil Microemulsions Prepared with Biocompatible Choline Carboxylic Acids for Improving the Transdermal Delivery of a Sparingly Soluble Drug

Recent Advances in Ionic Liquids in Biomedicine

The Emerging Role of Ionic Liquid-Based Approaches for Enhanced Skin Permeation of Bioactive Molecules: A Snapshot of the Past Couple of Years

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