Cholesterol Level and Stroke

Willey, Joshua Z.; Gonzalez‐Castellon, Marco

doi:10.1001/jamainternmed.2013.10100

Cited by 8 publications

(4 citation statements)

References 9 publications

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“…Consistent with previous studies, increased levels of UA showed higher concentrations of neutrophils and WBCs, except for those in the grade 1 group. These results further support the notion that higher SUA is closely linked to dyslipidemia in intravascular low-degree inflammation, which might promote atherosclerosis and ultimately induce cardiovascular diseases, such as hypertension, coronary artery disease, and stroke [48][49][50]. Several studies showed that the presence of neutrophils is necessary to induce an inflammatory reaction by monosodium urate monohydrate (MSUM) crystals.…”

Section: Int J Neurosci Downloaded From Informahealthcarecom By Univsupporting

confidence: 79%

Association of uric acid with traditional inflammatory factors in stroke

Zhu

Zou

Xiong

et al. 2015

International Journal of Neuroscience

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Uric acid (UA) plays an important role in the oxidant stress that causes inflammation. We assessed the association between UA and neutrophil ratio, white blood cell (WBC) count and blood lipid in 524 patients admitted with stroke. Stroke patients with a neutrophil ratio >70% displayed significantly lower UA levels than those with a neutrophil ratio ≤70% (p < 0.05). According to UA quartiles, neutrophil ratio, WBC count, and high-density lipoprotein cholesterol in the UA grade 1 group (≤214.10 μmol/L) were significantly increased over those in other UA grade groups. The results of stepwise regression analysis found that UA levels were inversely associated with neutrophil ratios (B ± SE = -1.11 ± 0.35), high-density lipoprotein cholesterol (B ± SE = -46.18 ± 14.17), total cholesterol (B ± SE = 9.82 ± 3.66), blood urea nitrogen (B ± SE = 6.30 ± 1.73), and creatinine (B ± SE = 0.63 ± 0.10). There is a correlationship between lower serum uric acid with neutrophil ratios in inflammation associated with stroke and the reasons need to be investigated further.

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Section: Int J Neurosci Downloaded From Informahealthcarecom By Univsupporting

confidence: 79%

Association of uric acid with traditional inflammatory factors in stroke

Zhu

Zou

Xiong

et al. 2015

International Journal of Neuroscience

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“…They are defined as disorders of lipoprotein metabolism, including lipoprotein overproduction or deficiency [8, 9]. Elevated LDL levels appear to increase the risk of ischemic stroke, while low HDL levels appear to be associated with a greater risk, whereas the importance of high TAG levels is less clear [8, 10]. The discordant results of observational studies might result from the heterogeneity of stroke, since dyslipidemia is less likely to play a major role in the pathogenesis of some ischemic stroke subtypes (e.g., lacunar and cardio-embolic strokes) [9].…”

Section: Introductionmentioning

confidence: 99%

The Prevalence of Dyslipidemia and Hyperglycemia among Stroke Patients: Preliminary Findings

Ali

Abuissa²,

Alawneh

et al. 2019

Stroke Research and Treatment

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Background/Aim Stroke or cerebrovascular accident is defined as sudden or sub acute onset of focal neurologic deficit, caused by the interruption of blood flow to parts of the brain. In this study, we aimed to investigate the prevalence of dyslipidemia and hyperglycemia among stroke patients in Palestine. Materials and Methods A total of 70 patients with stroke were included in a cross-sectional study between November 2017 and February 2018. Stroke patients were diagnosed based on a CT scan reviewed by a neurologist. Fasting venous blood samples were collected to measure the lipid profile (cholesterol, low-density lipoproteins (LDL), triacylglycerol (TAG), high-density lipoproteins (HDL)), fasting blood glucose (FBG), and glycosylated hemoglobin (HbA1c) levels. An interview-based questionnaire, included background data, past medical history, family history, and other risk factors for stroke, was filled for each patient. Results Based on our results, 28.57% of patients had high LDL, 17.1% had high cholesterol, 15.7% had high TAG and 61.3% had low HDL. About half of the patients (51.4%) had abnormal HbA1c and abnormal FBG (52.8%). The majority (67.1%) of patients were males, whereas, 11% of patients were obese (BMI of more than 30 kg/m2) and 51.4% were smokers. Regarding the family history of diseases, 81% of patients had a family history of hypertension, 50% had a family history of stroke, and 58% had a family history of diabetes mellitus. ConclusionMale gender and smoking were most likely to increase the risk of stroke. Risk factors like low HDL, high LDL, high FBG, high HbA1c, and hypertension contribute substantially to the incidence of stroke. A family history of stroke, hypertension and diabetes were significant risk factors for stroke.

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“…2,4 However, these relationships have not been as clearly established for stroke, and some studies have even questioned whether cholesterol is a risk factor for stroke. 5 In Asian populations, dyslipidemia is dominated by low HDL-C; conversely, dyslipidemia is dominated by high LDL-C in Western populations. 6 In China, there is a higher prevalence of low HDL-C than of high LDL-C. 7 Therefore, the relationship between HDL-C and the risk of stroke requires further analysis in China.…”

Section: Introductionmentioning

confidence: 99%

“… 2 , 4 However, these relationships have not been as clearly established for stroke, and some studies have even questioned whether cholesterol is a risk factor for stroke. 5 …”

Section: Introductionmentioning

confidence: 99%

High-Density Lipoprotein Cholesterol and the Risk of First Ischemic Stroke in a Chinese Hypertensive Population

Zhang¹,

Li²,

Yu³

et al. 2021

CIA

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Background and Purpose: Elevated high-density lipoprotein cholesterol (HDL-C) levels have displayed protection against cardiovascular disease. However, the association between specific lipoprotein classes and first ischemic stroke (IS) has not been well defined, particularly in higher-risk hypertensive populations. Our study evaluated the associations of HDL-C with first IS in a Chinese hypertensive population. Methods: The study population was obtained from a community-based cohort study of hypertension in Lianyungang and Rongcheng, China. A nested case-control design was used that included 2463 identified first IS cases and 2463 controls matched by age ± 1 year, sex, and region. Results: After adjusting for potential confounders, HDL-C was inversely associated with first IS (adjusted odds ratio [aOR]: 0.91; 95% confidence interval [CI]: 0.85-0.98). HDL-C levels of at least 65.4 mg/dL displayed a significant protective effect for first IS (aOR: 0.82; 95% CI: 0.69-0.98). Conversely, adverse effects of first IS were observed for low-density lipoprotein cholesterol (LDL-C) levels ≥138.1 mg/dL (aOR: 1.20; 95% CI: 1.02-1.42) and triglyceride (TG) levels ≥140.8 mg/dL (aOR: 1.27; 95% CI: 1.09-1.49). The risk associations of LDL-C and TG with first IS were attenuated in the presence of high HDL-C (≥53.0 mg/dL); an increased risk of first IS was only found in the presence of low HDL-C (<53.0 mg/dL) when LDL-C (aOR: 1.66; 95% CI: 1.19-2.31) and TG (aOR: 1.47; 95% CI: 1.17-1.84) were combined with HDL-C for analysis. Conclusion:In this community-based Chinese hypertensive population, higher HDL-C was a significant protective factor of first IS. These data add to the evidence describing the relationship between lipids and IS and suggest that HDL-C maybe is a marker of IS risk in Chinses hypertensive population.

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Cholesterol Level and Stroke

Cited by 8 publications

References 9 publications

Association of uric acid with traditional inflammatory factors in stroke

Association of uric acid with traditional inflammatory factors in stroke

The Prevalence of Dyslipidemia and Hyperglycemia among Stroke Patients: Preliminary Findings

High-Density Lipoprotein Cholesterol and the Risk of First Ischemic Stroke in a Chinese Hypertensive Population

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