Cholesterol granuloma of the paranasal sinuses

Abstract

Cholesterol granulomata of the middle ear occasionally accompany chronic middle-ear diseases with diminished ventilation. In the paranasal sinuses, especially in the frontal sinus, they have occasionally been mentioned in the literature.Disordered ventilation and impaired drainage are decisive pathogenic factors in the causation of cholesterol granuloma. Views remain divided on the source of the cholesterol and on the importance of bleeding in the development of cholesterol granuloma. Two patients with a cholesterol granuloma of the frontal sinus are presented and discussed.

Large Cholesterol Granuloma Arising From the Frontal Sinus. Case Report.

“…6) Cholesterol granuloma in the frontal sinus may be caused by disturbance of air drainage in the frontal sinus by a middle nose polyp (Table 1). 3,4,10,21) In our case, no causative nasal obstruction such as nasal…”

“…Symptoms may be caused by the extension of the granuloma to the orbit, and usually the roof of the orbit is eroded and destructed. 3) The main symptoms are bulging of the forehead and lateral-inferior displacement of the eye, accompanied by mass extension. In contrast, orbitofrontal cholesterol granuloma causes medialinferior displacement of the eye, because the orbitofrontal cholesterol granuloma arises adjacent to the lacrimal fossa.…”

“…2) Cholesterol granuloma arising from the paranasal sinus is uncommon. 1,3,6,10,16,18) Cholesterol granuloma is generally considered to be caused by poor ventilation and impaired drainage. Orbitofrontal cholesterol granuloma is uncommon, although some cases have been reported.…”

“…5,7,11,15) Most cases arose adjacent to the lacrimal fossa, whereas cholesterol granuloma originating from the frontal sinus is rare. 3,4,10,21) Treatment of cholesterol granuloma is usually simple evacuation and drainage, but large cases causing facial deformity require more intervention for cosmetic purposes. We report a case of large cholesterol granuloma of the frontal sinus extending to the orbit and anterior cranial fossa.…”

Tinnitus due to clarithromycin

“…[2][3][4] In a recent publication 4 the Cyfra 21-1 serum concentration is evaluated by means of an ELISA test kit. Deng…”