Cholesterol Content of the Blood in Heart Disease

Effects of statins on myocarditis: A review of underlying molecular mechanisms

“…Following the discovery of the role of cholesterol in cardiovascular disease (CVD) in 1856 (2), many studies confirmed the relationship between high blood cholesterol levels and an increased probability of CVD (3,4). Consequently, cholesterol reduction was identified as one of the main strategies for the treatment and control of CVD (5,6). The enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase was identified as a rate-limiting enzyme in the biosynthesis of cholesterol (7).…”

The Relationship of Streptolysin S Inhibitor to Phospholipids in the Serum of Human Beings and Experimental Animals

“…The concentration of serum cholesterol has also been observed to fall during the acute phase of this disease (14), and to be lower in patients with rheumatic heart disease than in patients with hypertensive or arteriosclerotic heart disease (15). Both lipids decrease in concentration in the serum of patients with a variety of acute and chronic infectious diseases (16,17).…”

“…It has been suggested that the fall in the concentration of serum lipids is not a feature of a particular disease process but rather a non-specific metabolic disturbance common to debilitation and malnutrition (18). While this view appears reasonable, it has not yet been demonstrated that the hypolipemia of infectious diseases is induced by either hyperpyrexia or dietary deficiency alone (15).…”