Chlorpromazine for psychosis induced aggression or agitation

Abstract

Overall the quality of evidence is limited, poor and dated. Where drugs that have been better evaluated are available, it may be best to avoid use of chlorpromazine. Where chlorpromazine is used for acute aggression or where choices are limited, relevant trials are possible and urgently needed.

Effectiveness of Intramuscular Chlorpromazine for Rapid Treatment of Psychomotor Agitation

“…Our study confirms the association between CPZ and hypotension, which has been previously described 3,7 . However, hypotension was transient and not severe in the 5.8% of our patients who reported this adverse effect.…”

Effectiveness of Intramuscular Chlorpromazine for Rapid Treatment of Psychomotor Agitation

“…Our study confirms the association between CPZ and hypotension, which has been previously described 3,7 . However, hypotension was transient and not severe in the 5.8% of our patients who reported this adverse effect.…”

Developing a Sustained and Productive Clinical Research Seminar

“…Our study confirms the association between CPZ and hypotension, which has been previously described. 3,7 However, hypotension was transient and not severe in the 5.8% of our patients who reported this adverse effect.…”

Brazilian guidelines for the management of psychomotor agitation. Part 2. Pharmacological approach

“…The most common FGAs used for rapid tranquilization due to agitation are chlorpromazine,15 levomepromazine,16 haloperidol,2 and droperidol 17. Promethazine,2 primarily known as an antihistamine, but belonging to the group of phenothiazines, may also be used 18…”

“…Chlorpromazine was mentioned in a study that reported a clinical trial showing no differences between chlorpromazine injection and haloperidol 15,19. IM chlorpromazine is related to sudden, serious hypotension, and status epilepticus 15.…”

Effectiveness of Intramuscular Chlorpromazine for Rapid Treatment of Psychomotor Agitation

“…Our study confirms the association between CPZ and hypotension, which has been previously described 3,7 . However, hypotension was transient and not severe in the 5.8% of our patients who reported this adverse effect.…”

Developing a Sustained and Productive Clinical Research Seminar

“…Our study confirms the association between CPZ and hypotension, which has been previously described. 3,7 However, hypotension was transient and not severe in the 5.8% of our patients who reported this adverse effect.…”

Brazilian guidelines for the management of psychomotor agitation. Part 2. Pharmacological approach

“…The most common FGAs used for rapid tranquilization due to agitation are chlorpromazine,15 levomepromazine,16 haloperidol,2 and droperidol 17. Promethazine,2 primarily known as an antihistamine, but belonging to the group of phenothiazines, may also be used 18…”

“…Chlorpromazine was mentioned in a study that reported a clinical trial showing no differences between chlorpromazine injection and haloperidol 15,19. IM chlorpromazine is related to sudden, serious hypotension, and status epilepticus 15.…”

Effectiveness of Intramuscular Chlorpromazine for Rapid Treatment of Psychomotor Agitation

“…Our study confirms the association between CPZ and hypotension, which has been previously described 3,7 . However, hypotension was transient and not severe in the 5.8% of our patients who reported this adverse effect.…”

Developing a Sustained and Productive Clinical Research Seminar

“…Our study confirms the association between CPZ and hypotension, which has been previously described. 3,7 However, hypotension was transient and not severe in the 5.8% of our patients who reported this adverse effect.…”

Brazilian guidelines for the management of psychomotor agitation. Part 2. Pharmacological approach

“…The most common FGAs used for rapid tranquilization due to agitation are chlorpromazine,15 levomepromazine,16 haloperidol,2 and droperidol 17. Promethazine,2 primarily known as an antihistamine, but belonging to the group of phenothiazines, may also be used 18…”

“…Chlorpromazine was mentioned in a study that reported a clinical trial showing no differences between chlorpromazine injection and haloperidol 15,19. IM chlorpromazine is related to sudden, serious hypotension, and status epilepticus 15.…”