Chlorpromazine and Communication Processes

Neuroleptics: Effects on Neuropsychological Function in Chronic Schizophrenic Patients

“…No significant alterations in performance after CPZ have been reported on the Tactile Performance Test. When CPZ is administered for less than a 3-week period, there are no significant effects on performance on the Finger Tapping Test (Kornetsky et al 1959; Fredericks and Finkel 1978), but some authors have reported improvement after 4 or more weeks of CPZ (Tourlentes et al 1958; Pugh 1968) or perphenazine (Pearl 1962). However, these results were not replicated by other laboratories (Spiegel and Keith-Spiegel 1967; Small et al 1972) where no significant effects were observed.…”

“…The remaining 12 studies did not specify the chronicity of the diagnosis of schizophrenia (Gilgash 1957; Porteus and Barclay 1957; Castner et al 1958; Grygier and Waters 1958; Nickols 1958; Tourlentes et al 1958; Judson and MacCasland 1960; Lloyd and Newbrough 1964; Small et al 1972; Spohn et al 1977; Fredericks and Finkel 1978; Killian et al 1984). Because of the failure of many of the studies to specify the criteria used for the diagnosis of schizophrenia and the evolution of that diagnosis during the time period in question, the subjects in this review are undoubtedly heterogeneous.…”

“…There were no consistent effects of chronic neuroleptic administration on vocabulary tasks. While two of the studies (Gardner et al 1955;Spiegel and Keith-Spiegel 1967) show significant improvement after chronic administration of either 400-600 mg/day of CPZ (Gardner et al 1955) or 50-150 mg/day of carphenazine (Spiegel and Keith-Spiegel 1967), these findings were not replicated by others (Abrams 1958;Grygier and Waters 1958;Tourlentes et al 1958). A closer examination of these studies (to rule out significant differences in length of hospitalization, age, or other factors) reveals no obvious explanation for the inconsistencies in these findings.…”

“…+( 0) performance on the Finger Tapping Test (Kornetsky et al 1959;Fredericks and Finkel 1978), but some authors have reported improvement after 4 or more weeks of CPZ (Tourlentes et al 1958;Pugh 1968) or perphenazine (Pearl 1962). However, these results were not replicated by other laboratories (Spiegel and Keith-Spiegel 1967;Small et al 1972) where no significant effects were observed.…”

Neuroleptics: Effects on Neuropsychological Function in Chronic Schizophrenic Patients

“…No significant alterations in performance after CPZ have been reported on the Tactile Performance Test. When CPZ is administered for less than a 3-week period, there are no significant effects on performance on the Finger Tapping Test (Kornetsky et al 1959; Fredericks and Finkel 1978), but some authors have reported improvement after 4 or more weeks of CPZ (Tourlentes et al 1958; Pugh 1968) or perphenazine (Pearl 1962). However, these results were not replicated by other laboratories (Spiegel and Keith-Spiegel 1967; Small et al 1972) where no significant effects were observed.…”

“…The remaining 12 studies did not specify the chronicity of the diagnosis of schizophrenia (Gilgash 1957; Porteus and Barclay 1957; Castner et al 1958; Grygier and Waters 1958; Nickols 1958; Tourlentes et al 1958; Judson and MacCasland 1960; Lloyd and Newbrough 1964; Small et al 1972; Spohn et al 1977; Fredericks and Finkel 1978; Killian et al 1984). Because of the failure of many of the studies to specify the criteria used for the diagnosis of schizophrenia and the evolution of that diagnosis during the time period in question, the subjects in this review are undoubtedly heterogeneous.…”

“…There were no consistent effects of chronic neuroleptic administration on vocabulary tasks. While two of the studies (Gardner et al 1955;Spiegel and Keith-Spiegel 1967) show significant improvement after chronic administration of either 400-600 mg/day of CPZ (Gardner et al 1955) or 50-150 mg/day of carphenazine (Spiegel and Keith-Spiegel 1967), these findings were not replicated by others (Abrams 1958;Grygier and Waters 1958;Tourlentes et al 1958). A closer examination of these studies (to rule out significant differences in length of hospitalization, age, or other factors) reveals no obvious explanation for the inconsistencies in these findings.…”

“…+( 0) performance on the Finger Tapping Test (Kornetsky et al 1959;Fredericks and Finkel 1978), but some authors have reported improvement after 4 or more weeks of CPZ (Tourlentes et al 1958;Pugh 1968) or perphenazine (Pearl 1962). However, these results were not replicated by other laboratories (Spiegel and Keith-Spiegel 1967;Small et al 1972) where no significant effects were observed.…”

Picture recognition as an index of social sensitivity in chronic schizophrenia: The effects of chlorpromazine.

“…The patients were asked, merely, to name ward mates from memory before being asked for positive and negative judgments. As in the Tourlentes et al (1958) study on drug effects were found in the frequency with which treated patients were named by others. However, compared with patients given placebo and phenobarbital, patients treated with chlorpromazine showed a significant increase in the number of "names known."…”

Neuroleptics: Effects on Neuropsychological Function in Chronic Schizophrenic Patients

“…No significant alterations in performance after CPZ have been reported on the Tactile Performance Test. When CPZ is administered for less than a 3-week period, there are no significant effects on performance on the Finger Tapping Test (Kornetsky et al 1959; Fredericks and Finkel 1978), but some authors have reported improvement after 4 or more weeks of CPZ (Tourlentes et al 1958; Pugh 1968) or perphenazine (Pearl 1962). However, these results were not replicated by other laboratories (Spiegel and Keith-Spiegel 1967; Small et al 1972) where no significant effects were observed.…”

“…The remaining 12 studies did not specify the chronicity of the diagnosis of schizophrenia (Gilgash 1957; Porteus and Barclay 1957; Castner et al 1958; Grygier and Waters 1958; Nickols 1958; Tourlentes et al 1958; Judson and MacCasland 1960; Lloyd and Newbrough 1964; Small et al 1972; Spohn et al 1977; Fredericks and Finkel 1978; Killian et al 1984). Because of the failure of many of the studies to specify the criteria used for the diagnosis of schizophrenia and the evolution of that diagnosis during the time period in question, the subjects in this review are undoubtedly heterogeneous.…”

“…There were no consistent effects of chronic neuroleptic administration on vocabulary tasks. While two of the studies (Gardner et al 1955;Spiegel and Keith-Spiegel 1967) show significant improvement after chronic administration of either 400-600 mg/day of CPZ (Gardner et al 1955) or 50-150 mg/day of carphenazine (Spiegel and Keith-Spiegel 1967), these findings were not replicated by others (Abrams 1958;Grygier and Waters 1958;Tourlentes et al 1958). A closer examination of these studies (to rule out significant differences in length of hospitalization, age, or other factors) reveals no obvious explanation for the inconsistencies in these findings.…”

“…+( 0) performance on the Finger Tapping Test (Kornetsky et al 1959;Fredericks and Finkel 1978), but some authors have reported improvement after 4 or more weeks of CPZ (Tourlentes et al 1958;Pugh 1968) or perphenazine (Pearl 1962). However, these results were not replicated by other laboratories (Spiegel and Keith-Spiegel 1967;Small et al 1972) where no significant effects were observed.…”

Picture recognition as an index of social sensitivity in chronic schizophrenia: The effects of chlorpromazine.

“…The patients were asked, merely, to name ward mates from memory before being asked for positive and negative judgments. As in the Tourlentes et al (1958) study on drug effects were found in the frequency with which treated patients were named by others. However, compared with patients given placebo and phenobarbital, patients treated with chlorpromazine showed a significant increase in the number of "names known."…”

Neuroleptics: Effects on Neuropsychological Function in Chronic Schizophrenic Patients

“…No significant alterations in performance after CPZ have been reported on the Tactile Performance Test. When CPZ is administered for less than a 3-week period, there are no significant effects on performance on the Finger Tapping Test (Kornetsky et al 1959; Fredericks and Finkel 1978), but some authors have reported improvement after 4 or more weeks of CPZ (Tourlentes et al 1958; Pugh 1968) or perphenazine (Pearl 1962). However, these results were not replicated by other laboratories (Spiegel and Keith-Spiegel 1967; Small et al 1972) where no significant effects were observed.…”

“…The remaining 12 studies did not specify the chronicity of the diagnosis of schizophrenia (Gilgash 1957; Porteus and Barclay 1957; Castner et al 1958; Grygier and Waters 1958; Nickols 1958; Tourlentes et al 1958; Judson and MacCasland 1960; Lloyd and Newbrough 1964; Small et al 1972; Spohn et al 1977; Fredericks and Finkel 1978; Killian et al 1984). Because of the failure of many of the studies to specify the criteria used for the diagnosis of schizophrenia and the evolution of that diagnosis during the time period in question, the subjects in this review are undoubtedly heterogeneous.…”

“…There were no consistent effects of chronic neuroleptic administration on vocabulary tasks. While two of the studies (Gardner et al 1955;Spiegel and Keith-Spiegel 1967) show significant improvement after chronic administration of either 400-600 mg/day of CPZ (Gardner et al 1955) or 50-150 mg/day of carphenazine (Spiegel and Keith-Spiegel 1967), these findings were not replicated by others (Abrams 1958;Grygier and Waters 1958;Tourlentes et al 1958). A closer examination of these studies (to rule out significant differences in length of hospitalization, age, or other factors) reveals no obvious explanation for the inconsistencies in these findings.…”

“…+( 0) performance on the Finger Tapping Test (Kornetsky et al 1959;Fredericks and Finkel 1978), but some authors have reported improvement after 4 or more weeks of CPZ (Tourlentes et al 1958;Pugh 1968) or perphenazine (Pearl 1962). However, these results were not replicated by other laboratories (Spiegel and Keith-Spiegel 1967;Small et al 1972) where no significant effects were observed.…”

Picture recognition as an index of social sensitivity in chronic schizophrenia: The effects of chlorpromazine.

“…The patients were asked, merely, to name ward mates from memory before being asked for positive and negative judgments. As in the Tourlentes et al (1958) study on drug effects were found in the frequency with which treated patients were named by others. However, compared with patients given placebo and phenobarbital, patients treated with chlorpromazine showed a significant increase in the number of "names known."…”