Chlorogenic acid alleviates obesity and modulates gut microbiota in high‐fat‐fed mice

Wang, Zhengyu; Lam, Kwok Wai; Hu, Jiamiao; Ge, Shengfang; Zhou, Arong; Zheng, Baodong; Zeng, Shaoxiao; Lin, Shaoling

doi:10.1002/fsn3.868

Cited by 125 publications

(105 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Previous studies have shown that A. keiskei chalcone extract prevents adiposity in mice fed a high‐fat diet (HFD) . In addition, flavonoids, coumarins, and phenolic acids in A. keiskei also have anti‐obesity effects . The ability of phytochemical‐rich foods to prevent obesity and metabolic diseases via gut microbiota modulation has been extensively reported .…”

Section: Introductionmentioning

confidence: 99%

Daily Supplementation with Fresh Angelica keiskei Juice Alleviates High‐Fat Diet‐Induced Obesity in Mice by Modulating Gut Microbiota Composition

Zhang

et al. 2019

Molecular Nutrition Food Res

View full text Add to dashboard Cite

Scope: Angelica keiskei is associated with several health benefits, but little is known about the effect of A. keiskei juice (AKJ), which is rich in polyphenols, coumarins, and other healthful agents, on high-fat diet-induced obesity or its relationship with intestinal microbiota composition changes. Methods and results: C57BL/6 mice are fed either a normal diet (ND group; n = 8), a high-fat diet (HFD group; n = 8), or a high-fat diet supplemented with AKJ (AKJ group; n = 8) for 10 weeks. The results show that AKJ prevents weight gain, lowered fat accumulation, blood glucose, serum lipid levels, hepatic steatosis, and modulates the level of expression of genes involved in lipid metabolism in mice with obesity. AKJ is found to normalize HFD-induced gut dysbiosis. Particularly, AKJ ameliorates HFD-dependent changes in the relative abundance of several taxa back to normal status (e.g., AKJ increased Bacteroides and decreased Mollicutes RF9, Ruminococcaceae UCG-014, Faecalibacterium, and Lactobacillus). Spearman's correlation analysis reveals that those genera are closely correlated with body weight, fasting serum glucose, and serum lipid levels. Conclusion: The results show that consumption of phytochemical-rich AKJ may prevent HFD-induced obesity and metabolic disorders via changes in metabolic genes and gut microbiota composition.

show abstract

Section: Introductionmentioning

confidence: 99%

Daily Supplementation with Fresh Angelica keiskei Juice Alleviates High‐Fat Diet‐Induced Obesity in Mice by Modulating Gut Microbiota Composition

Zhang

et al. 2019

Molecular Nutrition Food Res

View full text Add to dashboard Cite

show abstract

“…Also, in rats treated with chlorogenic acid-polyphenols (rich in green coffee bean), the concentration of beneficial bacteria such as Bacteroides, Bifidobacterium, and Lactobacillus spp. was significantly increased, while the composition of Ruminococcaceae, Desulfovibrionaceae, Lachnospiraceae, and Erysipelotrichaceae decreased with the experimental treatment [51]. Moreover, phenolic compounds extracted from Allium sativum juice decrease the growth of pathogenic bacteria such as Staphylococcus epidermidis and Klebsiella pneumoniae [52].…”

Section: Phenolic Compoundsmentioning

confidence: 96%

Role of Herbs and Medicinal Spices as Modulators of Gut Microbiota

Martínez¹,

Más²

2020

Herbs and Spices

View full text Add to dashboard Cite

Currently, herbs, medicinal spices, green medicine, or traditional Chinese medicine has gained many followers in the world, especially as a way of life and as an alternative to the indiscriminate use of synthetic medicines such as antibiotics. These natural products are rich in secondary metabolites or phytochemicals, which are chemical compounds of relatively complex structures and restricted distribution; these compounds have defensive functions against insects, bacteria, fungi, parasites, and viruses. Likewise, several studies have shown their effectiveness in the prevention and treatment of several diseases such as cancer, autoimmune diseases, gastrointestinal diseases, diabetes, neurodegenerative diseases, Crohn's disease, and human immunodeficiency virus (HIV), among others. In addition, this review addresses the mechanisms of action of the herbs and medicinal spices on intestinal microbiota, increasing competitive exclusion in the intestinal membrane and inhibiting bacterial translocation and damage to the intestinal barrier.

show abstract

“…CGA was shown to have potent antimicrobial activity by binding and permeabilizing the bacterial cell membrane . In ICR male mice (29–31 g) with HFD‐induced dysbiosis, oral CGA (150 mg d −1 for 6 weeks) inhibited the growth of Desulfovibrionaceae, Ruminococcaceae, Lachnospiraceae and Erysipelotrichaceae, and improved the growth of Bacteroidaceae and Lactobacillaceae, therefore reversing the HFD‐induced gut microbiota dysbiosis . In another study using male Kunming mice (20–30 g) with Pb‐induced cognitive impairments and hepatic and renal toxicity, oral CGA (30 mg kg −1 d −1 for 8 weeks) had a remarkable reversion effect of the Pb‐induced dysbiosis by increasing Helicobacter and decreasing Lachnospiraceae ratios …”

Section: Hca Interactions With the Gut Microbiotamentioning

confidence: 99%

Hydroxycinnamic acids and human health: recent advances

2019

View full text Add to dashboard Cite

There is an urgent need to improve human diet globally. Compelling evidence gathered over the past several decades suggests that a suboptimal diet is associated with many chronic diseases and may be responsible for more deaths than any other risks worldwide. The main components in our diet that need higher intake are whole grains, fruit and vegetables, and nuts and seeds; all of these are important sources of dietary fiber and polyphenols. The health benefits of dietary fiber and polyphenols are also supported by several decades of valuable research. However, the conclusions drawn from interventional human trials are not straightforward and the action mechanisms in improving human health are not fully understood. Moreover, there is a great inter‐individual variation caused by different individual capabilities of processing, absorbing and using these compounds effectively. Data on the bioavailability and bioefficacy of hydroxycinnamic acids (HCAs) are limited when compared to other classes of polyphenols (e.g. anthocyanins). This review aims to summarize the latest research advances related to HCA bioavailability and their biological effects revealed by epidemiological data, pre‐clinical and clinical studies. Moreover, we aim to review the effects of HCAs on gut microbiota diversity and function and its respective influence on host health. © 2019 Society of Chemical Industry

show abstract

Chlorogenic acid alleviates obesity and modulates gut microbiota in high‐fat‐fed mice

Cited by 125 publications

References 48 publications

Daily Supplementation with Fresh Angelica keiskei Juice Alleviates High‐Fat Diet‐Induced Obesity in Mice by Modulating Gut Microbiota Composition

Daily Supplementation with Fresh Angelica keiskei Juice Alleviates High‐Fat Diet‐Induced Obesity in Mice by Modulating Gut Microbiota Composition

Role of Herbs and Medicinal Spices as Modulators of Gut Microbiota

Hydroxycinnamic acids and human health: recent advances

Contact Info

Product

Resources

About