Chlorination of Tectochrysin and Pinostrobin in Methanol.

Abstract

Other natural productsOther natural products U 0800Chlorination of Tectochrysin and Pinostrobin in Methanol. -The chlorination of natural flavonoids (I) and (III) gives rise to their 6,8-dichloro derivatives. Under the reaction conditions, dichloropinostrobin (V) is transformed further into a tetrachloromethoxy derivative (VI). -(KULMAGAMBETOVA, E. A.; SEITEMBETOVA, A. G.; KULYJASOV, A. T.; RALDUGIN*, V. A.; GATILOV, Y. V.; SHAKIROV, M. M.; ADEKENOV, S. M.; TOLSTIKOV, G. A.; Russ. Chem. Bull. 52 (2003) 3, 752-754; Vorozhtsov Inst. Org. Chem., Sib. Branch Russ. Acad. Sci., Novosibirsk 630090, Russia; Eng.) -Staver 41-219

Synthesis and Cytotoxicity of Pinostrobin Hydrazone Derivatives

“…Hydrazone 2 reacted readily with substituted aromatic aldehydes (anisaldehyde, 4-fluorobenzaldehyde, 4-hydroxybenzaldehyde, 4-nitrobenzaldehyde, 2-chlorobenzaldehyde, 5-bromosalicylaldehyde, 2,4-dimethoxybenzaldehyde, 4-hydroxy-3-nitrobenzaldehyde, and 2-hydroxy-6-nitrosobenzaldehyde) to form the corresponding pinostrobin N-arylidenehydrazones (3)(4)(5)(6)(7)(8)(9)(10)(11) (68-95% yields) (Scheme 2).…”

“…Halosubstituted pinostrobin derivatives were synthesized [9]. Also, prenylation of 1 was described and the cytotoxicity of new derivatives against human tumor cells was studied [10].…”