Chlorhexidine Inhibits the Activity of Dental Cysteine Cathepsins

Scaffa, Polliana Mendes Cándia; Vidal, Cristina; Barros, Nilana M.T.; Gesteira, Tarsis F.; Carmona, Adriana K.; Breschi, Lorenzo; Pashley, David H.; Tjäderhane, Leo; Tersariol, Ivarne L.S.; Nascimento, Fábio D.; Carrilho, Marcela Rocha de Oliveira

doi:10.1177/0022034511435329

Cited by 189 publications

(176 citation statements)

References 32 publications

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“…40,68,70,71,72 It is well-known that certain substances are promising MMPs inhibitors, but the most studied in adhesive dentistry is chlorhexidine (CHX). 37,58,73,74 It is, in addition, also capable of inhibiting cysteine cathepsins (CCs) 75 the other key class of proteolytic enzymes identified in dentin. 76 CHX was accordingly shown to partially conserve the integrity of the hybrid layer, 77 , favoring bond durability.…”

Section: Enzymatic Inhibitorsmentioning

confidence: 99%

Bonding efficiency and durability: current possibilities

et al. 2017

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Bonding plays a major role in dentistry nowadays. Dental adhesives are used in association with composites to solve many restorative issues. However, the wide variety of bonding agents currently available makes it difficult for clinicians to choose the best alternative in terms of material and technique, especially when different clinical situations are considered. Moreover, although bonding agents allow for a more conservative restorative approach, achieving a durable adhesive interface remains a matter of concern, and this mainly due to degradation of the bonding complex in the challenging oral environment. This review aims to present strategies that are being used or those still in development which may help to prevent degradation. It is fundamental that professionals are aware of these strategies to counteract degradation as much as possible. None of them are efficient to completely solve this problem, but they certainly represent reasonable alternatives to increase the lifetime of adhesive restorations.

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Section: Enzymatic Inhibitorsmentioning

confidence: 99%

Bonding efficiency and durability: current possibilities

et al. 2017

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“…As chlorhexidine possesses desirable MMP-inhibitory properties 16) and outstanding substantivity to human dentin 17,18) , it has been well studied as a MMP-inhibitor to prevent dentin bond degradation 13,14,[19][20][21][22][23][24][25][26] . Recent studies revealed that cysteine cathepsins are also present in intact and carious dentin which may also contribute to the breakdown of the exposed collagen in dentin hybrid layers 27,28) , and that chlorhexidine can also inhibits the activity of dentin cysteine cathepsins 29) . Although the effect of chlorhexidine on the bond durability of coronal dentin to resin is well studied, few studies have evaluated the effect of chlorhexidine application on the bond durability of radicular dentin to resin.…”

Section: Introductionmentioning

confidence: 99%

Pre-treatment of radicular dentin by self-etch primer containing chlorhexidine can improve fiber post bond durability

Zhou¹,

Yang²,

Chen³

et al. 2013

Dent. Mater. J.

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We evaluated whether the pre-treatment of radicular dentin by ED Primer containing different concentrations of chlorhexidine can improve the bond durability of fiber post to radicular dentin. Experimental ED primers containing different concentrations of chlorhexidine (0%, 0.5% and 1.0%) were prepared. Thirty extracted maxillary anterior teeth were divided into 3 groups, each group corresponding to different chlorhexidine concentrations. Fiber posts were cemented in endodontically treated teeth with experimental ED primers and Panavia F. The bonded teeth were transversally sectioned into six slices and then were processed for thin slice push-out test 24 h later or after 18-months water storage. Eighteen-month storage resulted in significant bond strength reduction of all groups (p<0.05). The bond strength reduction of 1.0% group was significantly lower than that of control group and 0.5% group (p<0.05). In conclusion, the incorporation of 1.0% chlorhexidine into ED primer can extend the bond longevity of fiber post to radicular dentin.

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“…CHX effectively inhibits MMP-2, -8 and -9 (13,16,17) and cysteine cathepsins (18). In addition, many studies have demonstrated that CHX may improve the structural stability of collagen matrix in the hybrid layer and decrease time-dependent reduction in resin-dentin bond strength (14,17,19,20).…”

Section: Discussionmentioning

confidence: 99%

Effect of Metalloproteinase Inhibitors on the Microtensile Bond Strength of Composite Resin to Er:YAG Laser-Irradiated Dentin

et al. 2016

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This study evaluated the effect of matrix metalloproteinase (MMP) inhibitors -2% (CHX) and sodium fluoride (NaF) (5000 ppm) -on microtensile bond strength (μTBS) of composite resin to Er:YAG laser-irradiated dentin after chemical degradation of the bond interface. The occlusal surface of forty sound human molars was removed exposing the dentin surface (n=10), which was polished, irradiated with Er:YAG laser, acid etched and dried. Twenty specimens were rewetted with 2% CHX (control group) and 20 were rewetted with NaF (5000 ppm). The adhesive system was applied and a 4-mm-high plateau of light-cured composite resin was built up. Resin-dentin sticks were obtained with a rectangular cross-sectional area (0.8-1 mm 2 ) and were either stored in water at 37 °C for 24 h or submitted to chemical degradation. For chemical degradation, they were immersed in 10% NaOCl aqueous solution for 5 h and rinsed in water for 1 h. The sticks were submitted to microtensile test in a mechanical testing machine at 0.5 mm/min until failure. Fracture pattern was analyzed using SEM. μTBS values were calculated in MPa and submitted to analysis of variance ANOVA (α=0.05). The variance analysis showed that the 'MMP inhibitor ' and 'degradation' factors (p=0.214 and p=0.093, respectively) and interaction between the factors were not statistically significant (p=0.143). Mixed failure predominated in all groups. In conclusion, the 2% CHX and NaF 5000 ppm presented similar μTBS of composite resin to laser-irradiated dentin before and after chemical degradation

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Chlorhexidine Inhibits the Activity of Dental Cysteine Cathepsins

Cited by 189 publications

References 32 publications

Bonding efficiency and durability: current possibilities

Bonding efficiency and durability: current possibilities

Pre-treatment of radicular dentin by self-etch primer containing chlorhexidine can improve fiber post bond durability

Effect of Metalloproteinase Inhibitors on the Microtensile Bond Strength of Composite Resin to Er:YAG Laser-Irradiated Dentin

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