Chlorhexidine for the prevention of bloodstream infection associated with totally implantable venous ports in patients with solid cancers

Kao, Hsiang‐Fong; Chen, I‐Chun; Hsu, Chiun; Chang, Shih-Heng; Chien, Shiuh‐Shen; Chen, Yee‐Chun; Hu, Fu‐Chang; Yang, James Chih‐Hsin; Cheng, Ann‐Lii; Yeh, Kun‐Huei

doi:10.1007/s00520-013-2071-5

Cited by 14 publications

(10 citation statements)

References 29 publications

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“…41 In this regard, a recent study by Kao et al showed that topical skin disinfection with chlorhexidine was associated with a significant improvement in time to first port-a-cath associated BSI in patients with solid tumors compared with disinfection with povidoneiodine. 42 Routine replacement of CVCs and the application of topical antimicrobials in the insertion point are not recommended because they can favor fungal infections and the development of resistance. The use of CVC coated or impregnated with antimicrobials/antiseptics such as chlorhexidine and silver sulfadiazine or minocycline/ rifampin may reduce the risk of infections, although its benefit is relative and its cost is high.…”

Section: Prevention Of Catheter-related Bloodstream Infectionmentioning

confidence: 99%

Bloodstream infections in patients with solid tumors

2016

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Little information is currently available regarding bloodstream infection (BSI) in patients with solid tumors who, for a variety of reasons, are particularly predisposed to develop this condition. In this review we focus on the incidence, epidemiology, clinical features, etiology, antimicrobial resistance, and outcomes of BSI of adult cancer patients with solid tumors. Most episodes of BSI occur in nonneutropenic patients, in whom the site of primary or metastatic tumor often serves as the portal of entry. The urinary tract and the abdomen are the most frequent sources of infection, and cholangitis is the most common recurrent source of BSI. Gram-negative bacilli are becoming the leading cause of BSI in patients with solid tumors, and the rate of multidrug resistance is increasingly being recognized. The case-fatality rate in patients with solid tumors and BSI is high, especially among those with comorbidities, advanced neoplasms, corticosteroid therapy, and shock at presentation.

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Section: Prevention Of Catheter-related Bloodstream Infectionmentioning

confidence: 99%

Bloodstream infections in patients with solid tumors

2016

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“…They determined that using chlorhexidine reduced the incidence of CoNS-associated CRBSIs. Kao et al 16 detected skin cleansing with chlorhexidine helped to decrease gram-positive bacteria associated CRBSIs in adult patients with solid cancers.…”

Section: Discussionmentioning

confidence: 99%

Is antibiotic lock therapy effective for the implantable longterm catheter-related bloodstream infections in children?

et al. 2019

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Is antibiotic lock therapy effective for the implantable long-term catheter-related bloodstream infections in children? Turk J Pediatr 2019; 61: 895-904. Catheter-related bloodstream infections (CRBSIs) are an important problem in pediatric patients with central venous catheters. This study aimed to determine the incidence of CRBSIs, responsible pathogens and outcomes of antibiotic lock treatment (ALT) in pediatric patients. Between January 2010 and November 2015 all hospitalized pediatric hematology, oncology and immunology patients diagnosed with CRBSIs were retrospectively analyzed. Seventy-eight CRBSI episodes were detected in 60 pediatric patients. The incidence of CRBSIs was 4.20/1000 catheter days. The most frequently detected pathogen was methicillin-resistant coagulase-negative Staphylococcus. Pseudomonas aeruginosa, Klebsiella spp., and Escherichia coli were other commonly isolated microorganisms. ALT was administered in 42 patients. The success rate of ALT was 81% (34/42). Catheter was removed without ALT in 36 episodes. Common reasons for catheter removal were sepsis and causative microorganisms which had high probability of biofilm formation. CRBSIs are an important cause of morbidity and mortality in pediatric patients. ALT is safe and effective. It is possible to obtain satisfactory results when ALT is used with intravenous systemic antibiotics for CRBSIs, though in some cases catheter removal is necessary. ALT helps to prevent unnecessary catheter removal in pediatric patients.

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“…Kao ve ark. 'nın [42] yaptığı çalışmada ise solid tümörlü hastalarda kateter bakımında klorheksidin uygulamaları ile özellikle Gram-olumlu mikroorganizmalara bağlı SKİ-KDE hızında azalma rapor edilmiştir.…”

Section: Santral Kateter İlişkili Kan Dolaşımı Enfeksiyonu öNleme Demetiunclassified

Infection Control Bundles for the Prevention of Hospital Infections

Yüce¹,

Alp²

2018

mjima

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Chlorhexidine for the prevention of bloodstream infection associated with totally implantable venous ports in patients with solid cancers

Abstract: Chlorhexidine topical skin disinfection may prevent PABSI caused by Gram-positive bacteria in patients with solid cancers. The nonsignificant effect on preventing overall PABSI may be attributed to the high incidence of Gram-negative bacteria related PABSI.

Cited by 14 publications

References 29 publications

Bloodstream infections in patients with solid tumors

Bloodstream infections in patients with solid tumors

Is antibiotic lock therapy effective for the implantable longterm catheter-related bloodstream infections in children?

Infection Control Bundles for the Prevention of Hospital Infections

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