Cell Reports volume 3, issue 6, P1921-1931 2013 DOI: 10.1016/j.celrep.2013.04.027 View full text
Erika I. Lutter, Alexandra C. Barger, Vinod Nair, Ted Hackstadt

Abstract: Summary Chlamydia trachomatis replicates within a membrane bound compartment termed an inclusion. The inclusion membrane is modified by the insertion of multiple proteins known as Incs. In a yeast two-hybrid screen, an interaction was found between the inclusion membrane protein CT228 and MYPT1, a subunit of myosin phosphatase. MYPT1 was recruited peripherally around the inclusion while the phosphorylated inactive form was localized to active Src-family kinase-rich microdomains. Phosphorylated myosin light ch…

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