Chlamydia pneumoniae exposure and inflammatory markers in acute coronary syndrome (CIMACS)

Chandra, Harish; Choudhary, Nivedita; O'Neill, Christina; Boura, Judith; Timmis, Gerald C.; O’Neill, William W.

doi:10.1016/s0002-9149(01)01628-9

Cited by 25 publications

(11 citation statements)

References 28 publications

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“…However, it is not simply the sample exposure to C. pneumoniae, but the way in which the infection is handled by the individual immune system (host-pathogen interaction) that affects CHD [14].…”

Section: Discussionmentioning

confidence: 99%

“…The aim of the present work was to investigate whether chronic chlamydial infection is correlated to CHD. Furthermore, as systemic inflammation is a link between infection and the pathogenesis of atherosclerosis [12][13][14], we examined the role of C. pneumoniae and of inflammatory markers in the pathogenesis of coronary disease, correlated to the production of IL-7, which may be involved in the inflammatory processes observed in atherosclerosis and acute coronary syndromes [9].…”

Section: Introductionmentioning

confidence: 99%

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Relationship between Chlamydia pneumoniae infection, inflammatory markers, and coronary heart diseases

Carratelli

Nuzzo

Cozzolino

et al. 2006

International Immunopharmacology

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Relationship between Chlamydia pneumoniae infection, inflammatory markers, and coronary heart diseases

Carratelli

Nuzzo

Cozzolino

et al. 2006

International Immunopharmacology

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“…In the Helsinki Heart Study (24), these authors demonstrated that chronic C. pneumoniae infectionwhich they defined by the presence of an elevated IgA titer and LPS containing immune complexes-was an independent risk factor for the development of CHD 3 to 6 months before the coronary event. Since these initial reports, many studies have confirmed an association between antibodies to C. pneumoniae and coronary artery disease, but negative findings have also been frequently reported (2,4,12,13,18,19).…”

mentioning

confidence: 99%

Importance of Methodology in Determination of Chlamydia pneumoniae Seropositivity in Healthy Subjects and in Patients with Coronary Atherosclerosis

Hoymans¹,

Bosmans²,

Renterghem³

et al. 2003

J Clin Microbiol

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A significant difference in seroprevalence between patients and healthy subjects was observed with the LS EIA, while seropositivities in the two study groups appeared equal when the Focus MIF assay was applied. The MC rELISA and MCp sELISA gave statistically significant differences in antibody seroprevalence in patients with two-vessel disease or when the patient group combined individuals with a two-or a three-vessel disease, respectively. The concordance between MIF and other commonly used serological assays for C. pneumoniae IgG antibody detection is good to fair. The choice of serological assay has important implications for C. pneumoniae antibody seroprevalence, as well as for the relationship between C. pneumoniae seropositivity and coronary artery disease.

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“…Provision of direct proof of persistent C. pneumoniae infection by PCR is still not routine (4,7,31,45); therefore, serological analysis represents the current routine method for the diagnosis of C. pneumoniae infection. However, findings reported on the basis of seroepidemiology have been controversial (11,12,42). The diagnostic method used must be accurate for a study to be valid, and the different accuracies of the diagnostic methods used might explain the opposing findings.…”

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confidence: 99%

Comparison of Eleven Commercial Tests for Chlamydia pneumoniae -Specific Immunoglobulin G in Asymptomatic Healthy Individuals

et al. 2002

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The seroprevalence of anti-Chlamydia pneumoniae-specific immunoglobulin G (IgG) antibodies is high in the adult population. Experience is required to perform a microimmunofluorescence test (MIF), the current "gold standard" for serological diagnosis, and the assay still lacks standardization. Partially automated enzymelinked immunosorbent assays (ELISAs) and enzyme immunoassays (EIAs), which are more standardized and for which the reading of results is less subjective, have been developed. The different commercially available serological tests differ in their sensitivities and specificities, depending primarily on the antigen used. Therefore, we evaluated 11 different tests (10 were species specific, 1 was genus specific) for IgG antibodies using serum samples of 80 apparently healthy volunteers. The interpretation of the results was based on the results of the gold standard, MIF: a sample was judged positive if it was positive by at least three of the four different MIFs. Based on this internal standard, we found that 71% of the samples were positive, while 8% were false positive by some tests. The correlations between the results of the different MIFs ranged from 83 to 99%, and the correlations between the results of the MIFs and the different ELISAs and EIAs ranged from 78 to 98%. Comparison of the IgG titers measured by MIF showed good agreement (r ‫؍‬ 0.76 to 0.91). This analysis revealed that some ELISAs and EIAs fail to detect low IgG titers. The specificities of the species-specific tests varied from 95 to 100%, and the sensitivities varied from 58 to 100%. These results indicate that serological assays for the detection of anti-C. pneumoniae-specific IgG vary greatly in their sensitivities and specificities. MIF must still be considered the best method for the detection of IgG in apparently healthy subjects, but the sensitivities and specificities of new ELISAs approximate those of MIFs.

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Chlamydia pneumoniae exposure and inflammatory markers in acute coronary syndrome (CIMACS)

Cited by 25 publications

References 28 publications

Relationship between Chlamydia pneumoniae infection, inflammatory markers, and coronary heart diseases

Relationship between Chlamydia pneumoniae infection, inflammatory markers, and coronary heart diseases

Importance of Methodology in Determination of Chlamydia pneumoniae Seropositivity in Healthy Subjects and in Patients with Coronary Atherosclerosis

Comparison of Eleven Commercial Tests for Chlamydia pneumoniae -Specific Immunoglobulin G in Asymptomatic Healthy Individuals

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