1999
DOI: 10.1084/jem.189.12.1931
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Abstract: We report that chlamydiae, which are obligate intracellular bacterial pathogens, can inhibit interferon (IFN)-γ–inducible major histocompatibility complex (MHC) class II expression. However, the IFN-γ–induced IFN regulatory factor-1 (IRF-1) and intercellular adhesion molecule 1 (ICAM-1) expression is not affected, suggesting that chlamydia may selectively target the IFN-γ signaling pathways required for MHC class II expression. Chlamydial inhibition of MHC class II expression is correlated with degradation of … Show more

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Cited by 186 publications
(174 citation statements)
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“…Thus, it may be that chlamydia-dependent, proteasomelike activity activates caspase-1. This is analogous to what has been hypothesized for the inactivation of the transcription factor upstream stimulatory factor during C. trachomatis infection (38).…”
Section: Discussionmentioning
confidence: 65%
“…Thus, it may be that chlamydia-dependent, proteasomelike activity activates caspase-1. This is analogous to what has been hypothesized for the inactivation of the transcription factor upstream stimulatory factor during C. trachomatis infection (38).…”
Section: Discussionmentioning
confidence: 65%
“…Degradation of the transcription factors RFX5 and USF-1 during C. trachomatis infection has been shown to reduce expression of the major histocompatibility complex genes and thereby serve as a putative immune evasion strategy (45,46). Likewise, degradation of the BH3 (Bcl-2 homology domain 3) family of proapoptotic factors protects C. trachomatis-infected cells from programmed cell death (8,12,41).…”
Section: Discussionmentioning
confidence: 99%
“…In addition to cyclin B1, several other host proteins have been reported to undergo proteolytic cleavage in response to C. trachomatis infection (8,9,12,41,45,46). Degradation of the transcription factors RFX5 and USF-1 during C. trachomatis infection has been shown to reduce expression of the major histocompatibility complex genes and thereby serve as a putative immune evasion strategy (45,46).…”
Section: Discussionmentioning
confidence: 99%
“…For example, Chlamydia trachomatis has been found to inhibit interferon-gamma induced CIITA expression and therefore MHC class II gene expression, by causing degradation of the transcription factor Upstream Stimulatory Factor 1. 105 Moreover, the lack of MHC class II gene expression among patients with BLS is associated with reduced positive selection of CD4 þ T cells in the thymus and inability of mature CD4 þ cells to respond to antigens in the periphery. 31 As a result, BLS patients suffer from severe and recurrent bacterial and viral infections.…”
Section: Hla-drb9 Dr8mentioning
confidence: 99%