Chitosan–starch nanocomposite particles as a drug carrier for the delivery of bis-desmethoxy curcumin analog

Subramanian, Sindhuja Bala; Francis, Arul Prakash; Thiyagarajan, Devasena

doi:10.1016/j.carbpol.2014.07.053

Cited by 76 publications

(28 citation statements)

References 32 publications

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“…These results are found to be similar to previous reports (Adina et al 2010;Huang et al 2006;Medhat et al 2006). The IR spectrum of chitosan, however, showed three characteristic peaks at 3455 cm -1 (OH stretching), 1646 cm -1 (NH2), and 1080 cm -1 (C O C stretching), similar to the previous report by Subramanian et al (2014).…”

Section: Ft-ir Spectral Analysissupporting

confidence: 89%

Carbohydrates–chitosan composite carrier for Vero cell culture

Lin

Chen

2016

Cytotechnology

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In this study, carbohydrate-chitosan composite including glucose-chitosan, sucrose-chitosan and starch-chitosan with varied carbohydrate concentrations were prepared as carriers for Vero cell culture. Our results show that among these composites, 30 % starch-chitosan composite (STC) were the best carriers for the growth of Vero cells. The initial number of attached cells on the surface of composite carriers did not have any significant effect on subsequent cell production. A higher glucose level in the growth medium during the exponential phase of cell growth, however, played an important factor for cell production. Vero cells on the STC carriers were able to convert starch inside the composite carriers into glucose and further utilized the glucose for their growth. Moreover, by crosslink with serum the STC carriers supported an even better cell production in the normal medium without adding fetal bovine serum, as well as a good extracellular virus production. The STC composite is therefore a promising alternative carrier for Vero cell culture.

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Section: Ft-ir Spectral Analysissupporting

confidence: 89%

Carbohydrates–chitosan composite carrier for Vero cell culture

Lin

Chen

2016

Cytotechnology

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“…A nanocomposite of chitosan-starch loaded with BDMCA, (BDMCA-CS), an enhanced drug delivery system capable of inducing cytotoxicity in breast cancer cells has a very slow, sustained, and controlled diffused release of BDMCA in MCF-7 cancer cell line. 127 Breast cancer HER2-positive MCF-7 cell growth is inhibited in the presence of curcumin loaded PLGA nanoparticles. In the delivery system, curcumin can be released in a time and dose dependent manner intracellularly at low drug concentration yielding cell proliferation inhibition by G2/M cell arrest.…”

Section: The Effect Of Curcumin On Various Breast Cancer Signaling Pamentioning

confidence: 99%

Recent advances of curcumin and its analogues in breast cancer prevention and treatment

2015

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More than 230,000 diagnosed cases of invasive breast cancer in women was estimated in 2014 and an expected 40,000 deaths attributed to the aggressive carcinoma. An effective approach to diminish the morbidity and mortality of breast cancer is the development of chemopreventive and chemotherapeutic agents. Nutraceuticals have demonstrated their ability to proficiently halt carcinogenesis. The administration of natural compounds able to effectively serve as chemoprevention and chemotherapeutics without causing harm or adverse effects is imperative. Curcumin derived from the rhizome of Curcuma longa L., is a common spice of India, used for centuries because of its medicinal properties. The main component of curcumin possesses a wide range of biological activities; anti-proliferative, anti-inflammatory, and apoptotic characteristics modulated through the inactivation of pathways such as EGK and Akt/mTOR. In addition, curcumin alters the expression of cytokines, transcription factors, and enzymes involved in cell vitality. The in vivo application of curcumin in breast cancer is hindered by its limited bioavailabiity. The synthesis of curcumin analogues and delivery via nanoparticles has demonstrated enhanced bioavailability of curcumin in the malignancy. This review focuses on recent developments in the use of curcumin, curcumin analogues, and novel delivery systems as a preventive and therapeutic method for breast cancer.

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“…Fundamental research encompassing chemistry in nanoscience or nanotechnology, as they relate to achieving new developments in biomedicine, is important because nanomedicine has the realistic potential to bring a paradigm shift in the way diseases in humans are diagnosed and treated . Compared to chemotherapy, nanomedicines have been designed toward the aim of particular biomedical applications such as controllable release, lower systematic toxicity, and high drug bioavailability . Such a nano drug delivery system is an emerging technique to deliver multiple drugs, which are to be extensively distributed in the target site.…”

Section: Introductionmentioning

confidence: 99%

Phosphorylated κ‐Carrageenan‐Facilitated Chitosan Nanovehicle for Sustainable Anti‐Tuberculosis Multi Drug Delivery

et al. 2017

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Phosphorylated κ‐carrageenan has the potential to exhibit higher antioxidant activity than other polysaccharides. Low‐molecular‐weight κ‐carrageenan polysaccharides (LMW κ‐CAR) were prepared through oxidative degradation of high‐molecular‐weight κ‐carrageenan, and LMW κ‐CAR subjected into phosphorylation. Phosphorylated κ‐carrageenan (PCAR)‐chitosan (CS) nanoparticles was prepared by emulsification technique, followed by ionic gelation technique. Rifampicin (RF) and isoniazid (INH) were used as model drugs and encapsulated in CS‐PCAR nanocarriers. The encapsulation of drugs (RF and INH) in the CS‐PCAR polymeric carrier was verified by Fourier transform infrared spectroscopy (FT‐IR). The analysis of X‐ray diffraction (XRD) data demonstrated both RF and INH were loaded in the CS‐PCAR nanocarrier in an amorphous form. As observed by scanning electron microscopy (SEM) and transmission electron microscopy (TEM), CS‐PCAR nanoparticles shows spherical structure with soft surface and exhibited good aggregation, whereas INH and RF loaded CS‐PCAR nanoparticles had varying shapes like hexagonal, that indicates their different compositions and structures. Encapsulation efficiency was determined by UV‐Vis, which was interrelated to the initial concentration of INH and RF. Cumulative release of RF and INH from CS‐PCAR nanoparticles was observed in in‐vitro studies. An initial, tremendous release was observed from both RF and INH drug formulated carriers, which was followed a regular prolonged releases. The outcome of the drug release was controlled by their drug quantity, indicating that the discharge could be suffered by concentration of drug. The results suggest that CS‐PCAR nanoparticles are a pretty system for simultaneous release of RF and INH in the treatment of tuberculosis.

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Chitosan–starch nanocomposite particles as a drug carrier for the delivery of bis-desmethoxy curcumin analog

Cited by 76 publications

References 32 publications

Carbohydrates–chitosan composite carrier for Vero cell culture

Carbohydrates–chitosan composite carrier for Vero cell culture

Recent advances of curcumin and its analogues in breast cancer prevention and treatment

Phosphorylated κ‐Carrageenan‐Facilitated Chitosan Nanovehicle for Sustainable Anti‐Tuberculosis Multi Drug Delivery

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