Chitosan scaffolds, films and microgranules for medical application — preparation and drug release studies

Abstract

The paper presents various structural forms of chitosan for medical applications. These are films and microgranules for transdermal and oral application of active substances and porous scaffolds constituting support for the regenerating cells in bone tissue engineering. Tested porous systems were obtained by lyophilization or electrolytic method. Methods of sample preparation and the morphology analyses were presented. The influence of water on properties of transdermal systems and changes in release kinetics of active substances for microgranules and films under modification of their structures, were carried out.

Performance of PRP Associated with Porous Chitosan as a Composite Scaffold for Regenerative Medicine

“…Regarding the technological aspects, chitosan can be easily processed in diverse forms in the absence of toxic solvents, such as films [ 32 ], sponges [ 33 , 34 ], fibers [ 35 ], beads [ 36 ], hydrogels [ 37 ], and microparticles/nanoparticles [ 38 ]. Furthermore, chitosan supports sterilization [ 39 ], is abundant in nature, and requires only low-cost processing in nonaggressive ecological conditions before being used as a raw material [ 17 ].…”

The mineralization effect on chitosan hydrogel structure containing collagen and alkaline phosphatase

“…Response to Reviewers Figure 8. XRD diffraction patterns before (B) and after (A) mineralization for chitosan gel (1); chitosan-collagen 1.0 ml gel (2); chitosan-ALP gel (3) and chitosan-collagen-ALP (4) gel respectively 2.The structure and property of these hydrogel and their mineralization composites have been well characterized, however, the potential applications of these materials have not evaluated or at least discussed. In this study hydrogels were fabricated and evaluated by determining its structural changes after mineralization for biomedical applications as a scaffolds for bone regeneration.…”

“…Chitosan, as a biomaterial, has unique properties (biocompatible, biodegradable) and is used to formed scaffolds for cell culture. They are produced as either dried forms or gels [1][2][3][4][5][6][7].…”

Polymer coated magnetite nanoparticles for biomedical application. Part I. Preparation of nanoparticles Fe3O4 coated by polysaccharides

“…Chitozan ze wzglêdu na swoj¹ wytrzyma³ooeae mecha-niczn¹, biozgodnooeae, nietoksycznooeae oraz podatnooeae na modyfikacje chemiczne jest powszechnie stosowany do produkcji materia³ów medycznych [9][10][11][12]. W strukturze chitozanu wystêpuj¹ wolne grupy aminowe, które po sprotonowaniu w oerodowisku kwaoenym zyskuj¹ ³adunek dodatni i mog¹ reagowaae z ujemnie na³adowanymi grupami kwasów nukleinowych, co jest wykorzystywane np.…”