Chitosan hybrid microgels for oral drug delivery

Pellá, Michelly Cristina Galdioli; Simão, Andressa Renatta; Lima-Tenório, Michele K.; Tenório‐Neto, Ernandes T.; Scariot, Débora B.; Nakamura, Celso Vataru; Rubira, Adley F.

doi:10.1016/j.carbpol.2020.116236

Cited by 27 publications

(11 citation statements)

References 45 publications

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“…(18.7 ± 12.3) μm while the diameter of the microparticles produced using low-molecular-weight chitosan was (1.62 ± 0.38) μm. 38,58 Even though both microparticles were suitable for biological applications, the control over molecular weight and PDI would allow the production of particles with a narrower size distribution, preventing deviations from desired behaviors.…”

Section: Discussionmentioning

confidence: 99%

Adjusting Experimental Parameters to Modify Corn Starch with Glycidyl Methacrylate to Tune Specific Properties

Pellá¹,

Simão²,

Maurício³

et al. 2023

J. Braz. Chem. Soc.

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Chemical modification reactions are viable alternatives for improving the properties of starch because they allow the insertion of molecules that change the original behavior of the polymer. Glycidyl methacrylate (GMA) is an example of a vinylic molecule added to starch to decrease its hydrophilicity and improve mechanical properties. This modification reaction is affected by parameters like the volume of the modifier, time, and temperature. Furthermore, the correlation between these parameters might change the response of an individual parameter on the degree of substitution (DS), crystallinity (Xc), and molecular-weight-related parameters. This work evaluated how these effects and their correlations would affect the DS, Xc, molecular weight, and the polydispersity index (PDI) of starch. The results suggested that, while higher volumes of GMA and temperatures decreased the DS and Xc, the correlation between them increased the DS by 2.47, and Xc by 1.25. On the other hand, higher temperatures also favored the occurrence of hydrolysis. Also, although none of the parameter correlations had a significant effect on the assessed properties (at 95%), the statistical analysis confirmed that the correlation between two parameters changed the effect of individual parameters.

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Section: Discussionmentioning

confidence: 99%

Adjusting Experimental Parameters to Modify Corn Starch with Glycidyl Methacrylate to Tune Specific Properties

Pellá¹,

Simão²,

Maurício³

et al. 2023

J. Braz. Chem. Soc.

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“…Oral delivery [135] Dex-GCS/OHA Physical and Chemical crosslinking pH Eye Inflammation Lev was rapidly released from the hydrogel film within 10 min, with Dex initially releasing 18% of the total drug and then continuing to release.…”

Section: Physical and Chemical Crosslinking Phmentioning

confidence: 99%

Advances in Stimuli‐Responsive Chitosan Hydrogels for Drug Delivery Systems

Xia,

Ma,

et al. 2023

Macromolecular Bioscience

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Sustainable and controllable drug transport is one of the most efficient ways of disease treatment. Due to high biocompatibility, good biodegradability, and low costs, chitosan and its derivatives are widely used in biomedical fields. Specifically, chitosan hydrogel enables drugs to pass through biological barriers because of their abundant amino and hydroxyl groups that can interact with human tissues. Moreover, the multi‐responsive nature (pH, temperature, ions strength, and magnetic field, etc.) of chitosan hydrogels makes precise drug release a possibility. Here, the synthesis methods, modification strategies, stimuli‐responsive mechanisms of chitosan‐based hydrogels, and their recent progress in drug delivery are summarized. Chitosan hydrogels that carry and release drugs through subcutaneous (dealing with wound dressing), oral (dealing with gastrointestinal tract), and facial (dealing with ophthalmic, ear, and brain) are reviewed. Finally, challenges toward clinic application and the future prospects of stimuli‐responsive chitosan‐based hydrogels are indicated.

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“…The conformation of hydrogels with micrometric precision at the level of individual cells has allowed their application as artificial cells [22,23], drug and cell carrier systems [24,25], and assembled elemental units in artificial tissue construction [26,27]. Polysaccharide-based microgels are one of the most commonly used hydrogels.…”

Section: Family Of Hydrogelsmentioning

confidence: 99%

The Advantages of Polymeric Hydrogels in Calcineurin Inhibitor Delivery

2020

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In recent years, polymeric hydrogels (PolyHy) have been extensively explored for their applications in biomedicine as biosensors, in tissue engineering, diagnostic processes, and drug release. The physical and chemical properties of PolyHy indicate their potential use in regulating drug delivery. Calcineurin inhibitors, particularly cyclosporine (CsA) and tacrolimus (TAC), are two important immunosuppressor drugs prescribed upon solid organ transplants. Although these drugs have been used since the 1970s to significantly increase the survival of transplanted organs, there are concerns regarding their undesirable side effects, primarily due to their highly variable concentrations. In fact, calcineurin inhibitors lead to acute and chronic toxicities that primarily cause adverse effects such as hypertension and nephrotoxicity. It is suggested from the evidence that the encapsulation of calcineurin inhibitors into PolyHy based on polysaccharides, specifically alginate (Alg), offers effective drug delivery with a stable immunosuppressive response at the in vitro and in vivo levels. This not only may reduce the adverse effects but also would improve the adherence of the patients by the effective preservation of drug concentrations in the therapeutic ranges.

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Chitosan hybrid microgels for oral drug delivery

Cited by 27 publications

References 45 publications

Adjusting Experimental Parameters to Modify Corn Starch with Glycidyl Methacrylate to Tune Specific Properties

Adjusting Experimental Parameters to Modify Corn Starch with Glycidyl Methacrylate to Tune Specific Properties

Advances in Stimuli‐Responsive Chitosan Hydrogels for Drug Delivery Systems

The Advantages of Polymeric Hydrogels in Calcineurin Inhibitor Delivery

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