Abstract:Purpose: Regenerative medicine offers new techniques for osteoarthritis disorders, especially while considering simultaneous chondral and subchondral regenerations. Methods: Chitosan and hyaluronan were chemically bound as the chondral phase and the osteogenic layer was prepared with alginate and nano-hydroxyapatite (nHAP). These scaffolds were fixed by fibrin glue as a biphasic scaffold and then examined. Results: Scanning electron microscopy (SEM) confirmed the porosity of 61.45 ± 4.51 and 44.145 ± 2.81 % … Show more
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