Chitosan for overweight or obesity

Abstract

There is some evidence that chitosan is more effective than placebo in the short-term treatment of overweight and obesity. However, many trials to date have been of poor quality and results have been variable. Results obtained from high quality trials indicate that the effect of chitosan on body weight is minimal and unlikely to be of clinical significance.

Association of Microalbuminuria with Ischemic Heart Disease, Dyslipidemia and Obesity among Diabetic Patients: Experience from 5 Year Follow up Study of 1415 Patients

“…Association of weight and high BMI with blood pressure in young adults and children has been demonstrated in research trials [106][107][108][109][110][111][112][113]. Obesity is also associated with cardiovascular risk as well [114,115]. Our data has indicated that obesity is associated with development of high systolic BP and HTN.…”

Association of Microalbuminuria with Ischemic Heart Disease, Dyslipidemia and Obesity among Diabetic Patients: Experience from 5 Year Follow up Study of 1415 Patients

“…Association of weight and high BMI with blood pressure in young adults and children has been demonstrated in research trials [106][107][108][109][110][111][112][113]. Obesity is also associated with cardiovascular risk as well [114,115]. Our data has indicated that obesity is associated with development of high systolic BP and HTN.…”

A Meta-Analysis Evaluating the Impact of Chitosan on Serum Lipids in Hypercholesterolemic Patients

“…The results of our chitosan meta-analysis vary importantly from those of a previous Cochrane systematic review and meta-analysis last updated in 2005 [8] . The previous meta-analysis found that chitosan statistically significantly decreased total cholesterol (17.4 mg/dl), LDL cholesterol (6.6 mg/dl) and triglycerides (10.6 mg/dl) and increased HDL cholesterol (1.2 mg/dl) (p !…”

Complementary and Alternative Medicine for the Treatment of Obesity: A Critical Review

“…Although initial analyses ascribed a considerable weight loss to the use of chitosan preparations (mean loss: 1.7 kg; 95%CI: 1.3-2.1 kg, P < 0.00001), high quality trials, conducted later, revealed that the anti-obesity effect of chitosan was not nearly as large as the previous subliminal trials claimed. In fact, the anti-obesity effect of chitosan was deemed minimal at best and therefore clinically irrelevant ( 60 ).…”

“…Gambisan is a newly developed extract formula which was designated as HH911G at Kyung Hee University and Korean Medicine Hospital, Seoul, South Korea ( 60 ). In spite of the fact that its mechanism of action is yet to be understood, Gambisan has been clinically used as a popular supplement, with over 2800000 prescribed doses from 2010 to 2013.…”

Association of Microalbuminuria with Ischemic Heart Disease, Dyslipidemia and Obesity among Diabetic Patients: Experience from 5 Year Follow up Study of 1415 Patients

“…Association of weight and high BMI with blood pressure in young adults and children has been demonstrated in research trials [106][107][108][109][110][111][112][113]. Obesity is also associated with cardiovascular risk as well [114,115]. Our data has indicated that obesity is associated with development of high systolic BP and HTN.…”

A Meta-Analysis Evaluating the Impact of Chitosan on Serum Lipids in Hypercholesterolemic Patients

“…The results of our chitosan meta-analysis vary importantly from those of a previous Cochrane systematic review and meta-analysis last updated in 2005 [8] . The previous meta-analysis found that chitosan statistically significantly decreased total cholesterol (17.4 mg/dl), LDL cholesterol (6.6 mg/dl) and triglycerides (10.6 mg/dl) and increased HDL cholesterol (1.2 mg/dl) (p !…”

Complementary and Alternative Medicine for the Treatment of Obesity: A Critical Review

“…Although initial analyses ascribed a considerable weight loss to the use of chitosan preparations (mean loss: 1.7 kg; 95%CI: 1.3-2.1 kg, P < 0.00001), high quality trials, conducted later, revealed that the anti-obesity effect of chitosan was not nearly as large as the previous subliminal trials claimed. In fact, the anti-obesity effect of chitosan was deemed minimal at best and therefore clinically irrelevant ( 60 ).…”

“…Gambisan is a newly developed extract formula which was designated as HH911G at Kyung Hee University and Korean Medicine Hospital, Seoul, South Korea ( 60 ). In spite of the fact that its mechanism of action is yet to be understood, Gambisan has been clinically used as a popular supplement, with over 2800000 prescribed doses from 2010 to 2013.…”

Association of Microalbuminuria with Ischemic Heart Disease, Dyslipidemia and Obesity among Diabetic Patients: Experience from 5 Year Follow up Study of 1415 Patients

“…Association of weight and high BMI with blood pressure in young adults and children has been demonstrated in research trials [106][107][108][109][110][111][112][113]. Obesity is also associated with cardiovascular risk as well [114,115]. Our data has indicated that obesity is associated with development of high systolic BP and HTN.…”

A Meta-Analysis Evaluating the Impact of Chitosan on Serum Lipids in Hypercholesterolemic Patients

“…The results of our chitosan meta-analysis vary importantly from those of a previous Cochrane systematic review and meta-analysis last updated in 2005 [8] . The previous meta-analysis found that chitosan statistically significantly decreased total cholesterol (17.4 mg/dl), LDL cholesterol (6.6 mg/dl) and triglycerides (10.6 mg/dl) and increased HDL cholesterol (1.2 mg/dl) (p !…”

Complementary and Alternative Medicine for the Treatment of Obesity: A Critical Review

“…Although initial analyses ascribed a considerable weight loss to the use of chitosan preparations (mean loss: 1.7 kg; 95%CI: 1.3-2.1 kg, P < 0.00001), high quality trials, conducted later, revealed that the anti-obesity effect of chitosan was not nearly as large as the previous subliminal trials claimed. In fact, the anti-obesity effect of chitosan was deemed minimal at best and therefore clinically irrelevant ( 60 ).…”

“…Gambisan is a newly developed extract formula which was designated as HH911G at Kyung Hee University and Korean Medicine Hospital, Seoul, South Korea ( 60 ). In spite of the fact that its mechanism of action is yet to be understood, Gambisan has been clinically used as a popular supplement, with over 2800000 prescribed doses from 2010 to 2013.…”