Chitosan-coated doxorubicin nano-particles drug delivery system inhibits cell growth of liver cancer via p53/PRC1 pathway

Ye, Bailiang; Zheng, Rujie; Ruan, Xiuhang; Zheng, Zhenlin; Cai, Huajie

doi:10.1016/j.bbrc.2017.10.156

Cited by 56 publications

(19 citation statements)

References 29 publications

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“…In many studies, chitosan in its various forms is considered bactericidal [43,44], but these properties have recently been limited to biostatic ones [45][46][47][48]. The research carried out in the present work will also be useful in explaining this phenomenon.…”

Section: Introductionmentioning

confidence: 85%

Silver Nanoparticles on Chitosan/Silica Nanofibers: Characterization and Antibacterial Activity

Zienkiewicz-Strzałka

Deryło–Marczewska

Skorik

et al. 2019

IJMS

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A simple, low-cost, and reproducible method for creating materials with even silver nanoparticles (AgNP) dispersion was established. Chitosan nanofibers with silica phase (CS/silica) were synthesized by an electrospinning technique to obtain highly porous 3D nanofiber scaffolds. Silver nanoparticles in the form of a well-dispersed metallic phase were synthesized in an external preparation step and embedded in the CS/silica nanofibers by deposition for obtaining chitosan nanofibers with silica phase decorated by silver nanoparticles (Ag/CS/silica). The antibacterial activity of investigated materials was tested using Gram-positive and Gram-negative bacteria. The results were compared with the properties of the nanocomposite without silver nanoparticles and a colloidal solution of AgNP. The minimum inhibitory concentration (MIC) of obtained AgNP against Staphylococcus aureus (S. aureus) ATCC25923 and Escherichia coli (E. coli) ATCC25922 was determined. The physicochemical characterization of Ag/CS/silica nanofibers using various analytical techniques, as well as the applicability of these techniques in the characterization of this type of nanocomposite, is presented. The resulting Ag/CS/silica nanocomposites (Ag/CS/silica nanofibers) were characterized by small angle X-ray scattering (SAXS), X-ray diffraction (XRD), and atomic force microscopy (AFM). The morphology of the AgNP in solution, both initial and extracted from composite, the properties of composites, the size, and crystallinity of the nanoparticles, and the characteristics of the chitosan fibers were determined by electron microscopy (SEM and TEM).

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Section: Introductionmentioning

confidence: 85%

Silver Nanoparticles on Chitosan/Silica Nanofibers: Characterization and Antibacterial Activity

Zienkiewicz-Strzałka

Deryło–Marczewska

Skorik

et al. 2019

IJMS

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“…Ye et al, (2018) evaluated the effect of chitosan coated doxorubicin loaded nanocarrier in liver cancer where it showed excellent inhibitions of cell growth of liver cancer. 15 Loutfy et al, (2016) synthesized chitosan nanoparticle (CS-NPs) for evaluation of the in vitro human liver cancer cell model (HepG2). They investigated that the cytotoxic effect of CS-NPs towards liver cancer cells is relatively good and they suggested that CS-NPs are suitable for drug delivery proposes for liver cancer.…”

Section: Chitosan Nanoparticlesmentioning

confidence: 99%

<p>Nanocarrier-Based Therapeutics and Theranostics Drug Delivery Systems for Next Generation of Liver Cancer Nanodrug Modalities</p>

Ruman

Fakurazi

Masarudin

et al. 2020

IJN

111

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The development of therapeutics and theranostic nanodrug delivery systems have posed a challenging task for the current researchers due to the requirement of having various nanocarriers and active agents for better therapy, imaging, and controlled release of drugs efficiently in one platform. The conventional liver cancer chemotherapy has many negative effects such as multiple drug resistance (MDR), high clearance rate, severe side effects, unwanted drug distribution to the specific site of liver cancer and low concentration of drug that finally reaches liver cancer cells. Therefore, it is necessary to develop novel strategies and novel nanocarriers that will carry the drug molecules specific to the affected cancerous hepatocytes in an adequate amount and duration within the therapeutic window. Therapeutics and theranostic systems have advantages over conventional chemotherapy due to the high efficacy of drug loading or drug encapsulation efficiency, high cellular uptake, high drug release, and minimum side effects. These nanocarriers possess high drug accumulation in the tumor area while minimizing toxic effects on healthy tissues. This review focuses on the current research on nanocarrier-based therapeutics and theranostic drug delivery systems excluding the negative consequences of nanotechnology in the field of drug delivery systems. However, clinical developments of theranostics nanocarriers for liver cancer are considered outside of the scope of this article. This review discusses only the recent developments of nanocarrier-based drug delivery systems for liver cancer therapy and diagnosis. The negative consequences of individual nanocarrier in the drug delivery system will also not be covered in this review.

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“…Merging strong corrosion inhibitors with such coatings is necessary. When the corrosion inhibitor is trapped in the coating material, it is activated in the corrosive media and the inhibitor material can slowly exit the host matrix . Various studies have reported the positive effects of including organic inhibitors in the sol–gel matrix on improving corrosion resistance of metals and alloys.…”

Section: Introductionmentioning

confidence: 99%

“…When the corrosion inhibitor is trapped in the coating material, it is activated in the corrosive media and the inhibitor material can slowly exit the host matrix. [19][20][21] Various studies have reported the positive effects of including organic inhibitors in the sol-gel matrix on improving corrosion resistance of metals and alloys. In other studies, benzotriazole inhibitor is considered as sol-gel lattice modifier.…”

Section: Introductionmentioning

confidence: 99%

A study on the effect of presence of CeO₂ and benzotriazole on activation of self‐healing mechanism in ZrO₂ ceramic‐based coating

Dezfuli

Sabzi

2018

Int J Applied Ceramic Tech

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In this study, the effect of presence of CeO2 and benzotriazole inhibitor agent on activation of self‐healing reactions and the corrosion behavior of ZrO2 ceramic‐based coating are evaluated. The ZrO2 and ZrO2‐CeO2‐benzotriazole ceramic‐based coatings were synthesized using sol–gel process and heat treated at 150°C. Afterward, X‐ray diffraction analysis (XRD), and Field Emission Scanning Electron Microscopy (FE‐SEM) were utilized to evaluate the phase analysis and morphology of these coatings. In addition, Energy Dispersive Spectroscopy (EDS) was used for elemental analysis of obtained coatings. Corrosion and self‐healing behavior of the coatings were investigated in 3.5 wt% NaCl solution using Electrochemical Impedance Spectroscopy (EIS) and potentiodynamic polarization tests. The results of XRD analysis revealed the amorphous nature of both coatings. FE‐SEM observations and EDS analysis results showed the presence of benzotriazole inhibitor agent and self‐healing reactions in the cracks and defects of ZrO2‐CeO2‐benzotriazole ceramic‐based coating. Moreover, results of electrochemical tests revealed that the presence of CeO2 and benzotriazole inhibitor agent in the ZrO2 ceramic‐based coating results in intense increases in the corrosion resistance of this coating by activating the self‐healing mechanism and forming passive layers.

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Chitosan-coated doxorubicin nano-particles drug delivery system inhibits cell growth of liver cancer via p53/PRC1 pathway

Cited by 56 publications

References 29 publications

Silver Nanoparticles on Chitosan/Silica Nanofibers: Characterization and Antibacterial Activity

Silver Nanoparticles on Chitosan/Silica Nanofibers: Characterization and Antibacterial Activity

<p>Nanocarrier-Based Therapeutics and Theranostics Drug Delivery Systems for Next Generation of Liver Cancer Nanodrug Modalities</p>

A study on the effect of presence of CeO₂ and benzotriazole on activation of self‐healing mechanism in ZrO₂ ceramic‐based coating

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Chitosan-coated doxorubicin nano-particles drug delivery system inhibits cell growth of liver cancer via p53/PRC1 pathway

Cited by 56 publications

References 29 publications

Silver Nanoparticles on Chitosan/Silica Nanofibers: Characterization and Antibacterial Activity

Silver Nanoparticles on Chitosan/Silica Nanofibers: Characterization and Antibacterial Activity

<p>Nanocarrier-Based Therapeutics and Theranostics Drug Delivery Systems for Next Generation of Liver Cancer Nanodrug Modalities</p>

A study on the effect of presence of CeO2 and benzotriazole on activation of self‐healing mechanism in ZrO2 ceramic‐based coating

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A study on the effect of presence of CeO₂ and benzotriazole on activation of self‐healing mechanism in ZrO₂ ceramic‐based coating