Chitosan based bioadhesives for biomedical applications: A review

Hamedi, Hamid; Moradi, Sara; Hudson, Samuel M.; Tonelli, Alan E.; King, Martin W.

doi:10.1016/j.carbpol.2022.119100

Cited by 136 publications

(70 citation statements)

References 116 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Using a different method, Li et al reported surface-available chitosan in quantities of up to 89.5% ( Li et al, 2009 ). The surface availability is important not only for potential antimicrobial effects but also considering chitosan’s bioadhesive properties that can be beneficial in wound treatment ( Hamedi et al, 2022 ).…”

Section: Resultsmentioning

confidence: 99%

Chitosan-based delivery system enhances antimicrobial activity of chlorhexidine

Hemmingsen

Panchai²,

Julin³

et al. 2022

Front. Microbiol.

View full text Add to dashboard Cite

Infected chronic skin wounds and other skin infections are increasingly putting pressure on the health care providers and patients. The pressure is especially concerning due to the rise of antimicrobial resistance and biofilm-producing bacteria that further impair treatment success. Therefore, innovative strategies for wound healing and bacterial eradication are urgently needed; utilization of materials with inherent biological properties could offer a potential solution. Chitosan is one of the most frequently used polymers in delivery systems. This bioactive polymer is often regarded as an attractive constituent in delivery systems due to its inherent antimicrobial, anti-inflammatory, anti-oxidative, and wound healing properties. However, lipid-based vesicles and liposomes are generally considered more suitable as delivery systems for skin due to their ability to interact with the skin structure and provide prolonged release, protect the antimicrobial compound, and allow high local concentrations at the infected site. To take advantage of the beneficial attributes of the lipid-based vesicles and chitosan, these components can be combined into chitosan-containing liposomes or chitosomes and chitosan-coated liposomes. These systems have previously been investigated for use in wound therapy; however, their potential in infected wounds is not fully investigated. In this study, we aimed to investigate whether both the chitosan-containing and chitosan-coated liposomes tailored for infected wounds could improve the antimicrobial activity of the membrane-active antimicrobial chlorhexidine, while assuring both the anti-inflammatory activity and cell compatibility. Chlorhexidine was incorporated into three different vesicles, namely plain (chitosan-free), chitosan-containing and chitosan-coated liposomes that were optimized for skin wounds. Their release profile, antimicrobial activities, anti-inflammatory properties, and cell compatibility were assessed in vitro. The vesicles comprising chitosan demonstrated slower release rate of chlorhexidine and high cell compatibility. Additionally, the inflammatory responses in murine macrophages treated with these vesicles were reduced by about 60% compared to non-treated cells. Finally, liposomes containing both chitosan and chlorhexidine demonstrated the strongest antibacterial effect against Staphylococcus aureus. Both chitosan-containing and chitosan-coated liposomes comprising chlorhexidine could serve as excellent platforms for the delivery of membrane-active antimicrobials to infected wounds as confirmed by improved antimicrobial performance of chlorhexidine.

show abstract

Section: Resultsmentioning

confidence: 99%

Chitosan-based delivery system enhances antimicrobial activity of chlorhexidine

Hemmingsen

Panchai²,

Julin³

et al. 2022

Front. Microbiol.

View full text Add to dashboard Cite

show abstract

“…Some of its features include biocompatibility, biodegradability, antimicrobial nature, non-toxicity, hemostatic nature, antioxidant property, muco-adhesiveness, and structural similarity with extracellular matrix components, and protein degradability, makes it suitable for periodontal regeneration. 64 , 65 Different novel bio-scaffolds from chitosan can be created via surface alteration and lyophilization. Also, chitosan can easily be processed into different functional forms such as gels, nanofibers, membranes, beads, nanofibrils, nanoparticles, microparticles, scaffolds, and sponge-like structures.…”

Section: Chitosan-based Layered Scaffoldsmentioning

confidence: 99%

Layered scaffolds in periodontal regeneration

Abedi¹,

Rajabi²,

Kharaziha³

et al. 2022

Journal of Oral Biology and Craniofacial Research

View full text Add to dashboard Cite

“…Chitosan is a β-1,4-linked linear polymer of glucosamine extracted from crustacean shells, insects, and fungi by chitin deacetylation with concentrated alkalis (most frequently) or treatment with deacetylases (very rarely because of the high cost of enzymes) [ 1 , 2 , 3 ]. Chitosan-based materials are used for food packaging [ 4 , 5 ], encapsulation of food supplements [ 6 , 7 ], inhibition of formation of acrylamide and 5-hydroxymethylfurfural during thermal food processing [ 8 ], drug delivery [ 9 ], as a component of hemostatic agents and wound dressings [ 10 , 11 ], and as a material for suture-free surgery [ 12 , 13 ]. When used directly as a component of functional foods and therapeutic and preventive nutrition, chitosan can bind fatty and bile acids, phospholipids, and gliadin due to its ability to form micelles, thus making it possible to treat celiac disease, reduce cholesterol levels, and treat arthrosis and osteoporosis [ 8 , 14 , 15 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

Mechanical Amorphization of Chitosan with Different Molecular Weights

et al. 2022

View full text Add to dashboard Cite

Mechanical amorphization of three chitosan samples with high, medium, and low molecular weight was studied. It is shown that there are no significant differences between the course of amorphization process in a planetary ball mill of chitosan with different molecular weights, and the maximum degree of amorphization was achieved in 600 s of high intensity mechanical action. Specific energy consumption was 28 kJ/g, being comparable to power consumption for amorphization of cellulose determined previously (29 kJ/g) and 5–7-fold higher than that for amorphization of starch (4–6 kJ/g). Different techniques for determining the crystallinity index (CrI) of chitosan (analysis of the X-ray diffraction (XRD) data, the peak height method, the amorphous standard method, peak deconvolution, and full-profile Rietveld analysis) were compared. The peak height method is characterized by a broader working range but provides deviated CrI values. The peak deconvolution method (with the amorphous Voigt function) makes it possible to calculate the crystallinity index of chitosan with greater accuracy, but the analysis becomes more difficult with samples subjected to mechanical processing. In order to refine the structure and calculation of CrI by the Rietveld method, an attempt to optimize the structure file by the density functional theory (DFT) method was performed. The averaged profile of amorphous chitosan approximated by an eighth-order Fourier model improved the correctness of the description of the amorphous contribution for XRD data processing. The proposed equation may be used as a universal standard model of amorphous chitosan to determine the crystallinity index both for the amorphous standard method and for peak deconvolution of XRD patterns for arbitrary chitosan samples.

show abstract

Chitosan based bioadhesives for biomedical applications: A review

Cited by 136 publications

References 116 publications

Chitosan-based delivery system enhances antimicrobial activity of chlorhexidine

Chitosan-based delivery system enhances antimicrobial activity of chlorhexidine

Layered scaffolds in periodontal regeneration

Mechanical Amorphization of Chitosan with Different Molecular Weights

Contact Info

Product

Resources

About