Chitosan associated with chlorhexidine in gel form: Synthesis, characterization and healing wounds applications

Ferreira, Maria Onaira Gonçalves; Lima, Idglan S. de; Morais, Alan Ícaro Sousa; Silva, Silvana Oliveira; Carvalho, Rusbene Bruno Fonseca de; Ribeiro, Alessandra Braga; Osajima, Josy Anteveli; Filho, Edson Cavalcanti da Silva

doi:10.1016/j.jddst.2018.12.003

Cited by 24 publications

(21 citation statements)

References 32 publications

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“…The wound treatment of each group was administered topically in the injured region, with the products assigned to each group. The wounds were cleaned with saline (0.9%) before the everyday new application of the test products (Ferreira et al, 2019). Euthanasia of three animals from each group was performed on 3rd, 7th, 14th, and 21st days and it was provoked by using pentobarbital overdose 10-15 mg/100 g of animal weight, intraperitoneally, followed by skin flap excision for histological analysis, and finish on 21st day of treatment.…”

Section: Wound Treatment and Evaluationmentioning

confidence: 99%

“…After euthanization, a skin fragment of the backs of three animals in each group was desiccated on 3rd, 7th, 14th, and 21st days of treatment, the size of this fragment was sufficient to cover the entire injured region (Ferreira et al, 2019). All skin lesion samples obtained were fixed in 10% buffered lkformaldehyde for 24 h and taken to a battery with a crescent sequence of alcohol for dehydration and diaphanized in xylol.…”

Section: Qualitative Histopathological Evaluationmentioning

confidence: 99%

“…The 1700-1500 cm −1 regions were observed the presence of C=O of fatty acids of oil structure [19,20]. The graphics of CGB material, Figure 2b, was observed that the spectrum was a combination of the main bands characteristic of chitosan and buriti oil [3]. Figure 3 showed the micrograph images of the synthesized materials after lyophilized, with three images (different magnifications) related to the chitosan gel (a-c) and the other three (d-f) referring to the chitosan gel with buriti oil.…”

Section: Infrared Spectroscopymentioning

confidence: 99%

“…Chitosan is a biopolymer that has been widely studied to be used in several areas, as it has biocompatibility, biodegradability, non-toxicity, mucoadhesion, and antimicrobial activity [1]. It has been used in tissue engineering [2], dressings, accelerating healing [3,4], wound care [5], and other biomedical and pharmaceutical applications [6].…”

Section: Introductionmentioning

confidence: 99%

“…Chitosan gel associated with other substances may acquire new properties that optimize and extend its applicability and efficiency in wound healing [3]. In this work, the substance associated with the chitosan gel was buriti oil (Mauritia flexuosa L.), which presents an adequate profile in bioactive and antioxidant compounds, and it can be further explored properly by regional industries for the development of products.…”

Section: Introductionmentioning

confidence: 99%

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Biocompatible Gels of Chitosan–Buriti Oil for Potential Wound Healing Applications

et al. 2020

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The buriti oil (Mauritia flexuosa L.) can be associated with polymeric matrices for biomedical applications. This study aimed to evaluate the effect of chitosan gel (CG) associated with buriti oil (CGB) as a healing agent. The fatty acids and volatile compounds composition of buriti oil were performed and the composite gels were characterized using FTIR and thermal analysis. Biological tests including antimicrobial, antioxidant, anti-inflammatory and healing effects were also investigated. Buriti oil is composed of oleic and palmitic acids, and the main volatile compounds were identified. The buriti oil did not show antimicrobial activity, on the other hand, the composite gel (chitosan and oil) proved to be efficient against Staphylococcus aureus and Klebsiella pneumonia at the 10 mg/mL. Similar behavior was observed for antioxidant activity, determined by the β-carotene bleaching assay, composite gels presenting higher activity and buriti oil showed anti-inflammatory activity, which may be related to the inhibition of the release of free radicals. Regarding wound healing performed using in vivo testing, the composite gel (CGB) was found to promote faster and complete wound retraction. The results indicated that the gel chitosan–buriti oil has a set of properties that improve its antibacterial, antioxidant and healing action, suggesting that this material can be used to treat skin lesions.

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Section: Wound Treatment and Evaluationmentioning

confidence: 99%

Section: Qualitative Histopathological Evaluationmentioning

confidence: 99%

Section: Infrared Spectroscopymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Biocompatible Gels of Chitosan–Buriti Oil for Potential Wound Healing Applications

et al. 2020

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Synthesis and Characterization of Cassava Gum Hydrogel Associated with Chlorhexidine and Evaluation of Release and Antimicrobial Activity

Lima,

Silva,

Nascimento

et al. 2024

Macromolecular Bioscience

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Hydrogels from natural sources are attracting increasing interest due to their ability to protect biologically active molecules. Starch extracted from cassava tubers is a promising material for synthesizing these hydrogels. Copolymerization of cassava gum and incorporation of Chlorhexidine Digluconate (CLX) into the hydrogels was confirmed by changes in the crystallographic profile, as observed through X‐ray diffraction (XRD), and a shift in the 1000 cm−1 band in the Fourier‐transform infrared spectroscopy (FTIR) spectrum. The Differential Scanning Calorimetry (DSC) revealed changes in the decomposition temperature of the synthesized hydrogels related to CLX volatility. Micrographs illustrate the material's porosity. Release tests indicate a constant linear release over 72 hours, while antimicrobial activity against Staphylococcus aureus, Escherichia coli, and Candida albicans was satisfactory, with 100% effectiveness from 0.5% CLX and the formation of inhibition halos. Toxicity and biocompatibility studies show no cytotoxicity. The continuous release of chlorhexidine is promising for components of biomedical implants and applications as it can ensure antimicrobial action according to specific therapeutic needs.This article is protected by copyright. All rights reserved

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Traditional and advanced wound dressings: physical characterization and desirable properties for wound healing

Bülbül

Okur

et al. 2022

Natural Polymers in Wound Healing and Repair

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Chitosan associated with chlorhexidine in gel form: Synthesis, characterization and healing wounds applications

Cited by 24 publications

References 32 publications

Biocompatible Gels of Chitosan–Buriti Oil for Potential Wound Healing Applications

Biocompatible Gels of Chitosan–Buriti Oil for Potential Wound Healing Applications

Synthesis and Characterization of Cassava Gum Hydrogel Associated with Chlorhexidine and Evaluation of Release and Antimicrobial Activity

Traditional and advanced wound dressings: physical characterization and desirable properties for wound healing

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