Chitosan as a machine for biomolecule delivery: A review

Mohammadi, Zohreh; Eini, Maryam; Rastegari, Ali; Tehrani, Morteza Rafiee

doi:10.1016/j.carbpol.2020.117414

Cited by 56 publications

(27 citation statements)

References 136 publications

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“…chitosan as an anti-influenza agent (Zheng et al 2016;Mohammadi et al 2020;Popescu et al 2020). Hassan et al (2016) tested the antiviral activity of chitosan against Rift Valley Fever virus (RVFV), Herpes Simplex-1 (HSV-1) and Coxsackie viruses.…”

Section: Accepted Articlementioning

confidence: 99%

“…The researchers used bifunctional fusion protein vector in order to achieve dendritic cell selective targeting. The increase in the mucosal IgA and systemic IgG against N-protein indicating that chitosan is a promising gene delivery vehicle (Sun et al 2009;Mohammadi et al 2020). Chitosan nanoparticles were used for intranasal delivery of plasmid DNA encoding nucleocapsid SARS-CoV-2.…”

Section: Chitosan In Vaccine Preparations Against Coronavirusesmentioning

confidence: 99%

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A review of the antiviral activity of Chitosan, including patented applications and its potential use against COVID‐19

Jaber

Al-Remawi

Al-Akayleh

et al. 2021

J of Applied Microbiology

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Chitosan is a plentiful organic polysaccharide, which can be relatively easily obtained by chemical modification of animal or fungal source materials. Chitosan and its derivatives have been shown to exhibit direct anti-viral activity, to be useful vaccine adjuvants and to have potential anti-SARS-CoV-2 activity. This thorough and timely review looks at the recent history of investigations into the role of chitosan and its derivatives as an antiviral agent and proposes a future application in the treatment of endemic SARS-CoV-2.

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Section: Accepted Articlementioning

confidence: 99%

Section: Chitosan In Vaccine Preparations Against Coronavirusesmentioning

confidence: 99%

A review of the antiviral activity of Chitosan, including patented applications and its potential use against COVID‐19

Jaber

Al-Remawi

Al-Akayleh

et al. 2021

J of Applied Microbiology

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“…It possess unique chemical and physical properties by controlling the length of chitin chain and the degree of chemical processing, such as the depolymerization and the deacetylation [ 36 ]. The structure of chitosan contains some amino groups and hydroxyl groups, that are readily available for crosslinking [ 37 ]. The complexation between cations and anions is easily happened [ 38 ], resulting in the formation of chitosan with various morphologies, including nanoparticles, films, and hydrogels have been developed.…”

Section: Structures and Properties Of Biopolymersmentioning

confidence: 99%

Recent Advances in Natural Functional Biopolymers and Their Applications of Electronic Skins and Flexible Strain Sensors

Wang

Sun

et al. 2021

Polymers

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In order to replace nonrenewable resources and decrease electronic waste disposal, there is a rapidly rising demand for the utilization of reproducible and degradable biopolymers in flexible electronics. Natural biopolymers have many remarkable characteristics, including light weight, excellent mechanical properties, biocompatibility, non-toxicity, low cost, etc. Thanks to these superior merits, natural functional biopolymers can be designed and optimized for the development of high-performance flexible electronic devices. Herein, we provide an insightful overview of the unique structures, properties and applications of biopolymers for electronic skins (e-skins) and flexible strain sensors. The relationships between properties and sensing performances of biopolymers-based sensors are also investigated. The functional design strategies and fabrication technologies for biopolymers-based flexible sensors are proposed. Furthermore, the research progresses of biopolymers-based sensors with various functions are described in detail. Finally, we provide some useful viewpoints and future prospects of developing biopolymers-based flexible sensors.

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“…Exposure to heat, change of pH, change of salt concentration, and strain are all susceptible to result in protein misfolding. Moreover, endogenous proteases are responsible for most of the inactivation processes of protein drugs in the body [ 105 ]. Once conjugated to CS through electrostatic interactions, proteins are stabilized and protected from exposure to chemical and physical strains.…”

Section: Non-covalent Modificationsmentioning

confidence: 99%

Chitosan Functionalization: Covalent and Non-Covalent Interactions and Their Characterization

2021

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Chitosan (CS) is a natural biopolymer that has gained great interest in many research fields due to its promising biocompatibility, biodegradability, and favorable mechanical properties. The versatility of this low-cost polymer allows for a variety of chemical modifications via covalent conjugation and non-covalent interactions, which are designed to further improve the properties of interest. This review aims at presenting the broad range of functionalization strategies reported over the last five years to reflect the state-of-the art of CS derivatization. We start by describing covalent modifications performed on the CS backbone, followed by non-covalent CS modifications involving small molecules, proteins, and metal adjuvants. An overview of CS-based systems involving both covalent and electrostatic modification patterns is then presented. Finally, a special focus will be given on the characterization techniques commonly used to qualify the composition and physical properties of CS derivatives.

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Chitosan as a machine for biomolecule delivery: A review

Cited by 56 publications

References 136 publications

A review of the antiviral activity of Chitosan, including patented applications and its potential use against COVID‐19

A review of the antiviral activity of Chitosan, including patented applications and its potential use against COVID‐19

Recent Advances in Natural Functional Biopolymers and Their Applications of Electronic Skins and Flexible Strain Sensors

Chitosan Functionalization: Covalent and Non-Covalent Interactions and Their Characterization

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