2022
DOI: 10.1002/jctb.7018
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Abstract: BACKGROUND Enantiomerically pure compounds occupy an important position in industrial production of pharmaceuticals, food, chemical engineering, etc. The separation of d and l molecules is an important and challenging task. The ‘tailor‐made’ additive method is a simple and efficient crystallization separation technology. However, according to reports, there is a poor crystal yield when obtaining a relatively ideal enantiopurity and vice versa. Furthermore, the crystallization time always needs to be controlled… Show more

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Cited by 4 publications
(2 citation statements)
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“…Zhou et al 149 proposed effective strategies to selectively crystallize pure D-Glu from a racemic solution of DL-Glu. Only pure D-crystals were precipitated from the solution via precisely controlling the amount of L-additives in the solution or combining the circulation crystallization technology.…”
Section: Process Optimization For Chiral Resolutionmentioning
confidence: 99%
“…Zhou et al 149 proposed effective strategies to selectively crystallize pure D-Glu from a racemic solution of DL-Glu. Only pure D-crystals were precipitated from the solution via precisely controlling the amount of L-additives in the solution or combining the circulation crystallization technology.…”
Section: Process Optimization For Chiral Resolutionmentioning
confidence: 99%
“…Concurrently, the use of the enantiomer pure glutamic acid obtained thereby will effectively avoid the adverse consequences of the racemate on the organism and even the human body and avoid the recurrence of events similar to “thalidomide”. So far, the methods for separating glutamic acid enantiomers mainly included ultrasonic field, MISPE, crystallization separation technology, and CE . In unison, the approaches for detecting glutamic acid enantiomers incorporated fluorometry, electrochemical, continuous fractional crystallization, ELISA, microbiological assay, ion channel sensors, etc.…”
Section: Introductionmentioning
confidence: 99%