Chiral resolution of a carboxylic acid using droplet counter-current chromatography

Enantiomer Separation by Countercurrent Chromatography Using Cinchona Alkaloid Derivatives as Chiral Selectors

“…However, as mentioned before, there are not many examples described of enantiomer separations using this technique. [23][24][25][26][27][28][29][30][31][32][33][34] The difficulty of finding a suitable CS (being highly selective for the given racemic compounds) and the appropriate system of solvents, which might not suppress this selectivity and keep the capacity to elute the chiral solutes of interest, can presumably be the main reasons for the scarcity of applications in this field. The CSs employed until present were in general those directly used also in liquid chromatography or in other separation techniques.…”

Enantiomer Separation by Countercurrent Chromatography Using Cinchona Alkaloid Derivatives as Chiral Selectors

“…However, as mentioned before, there are not many examples described of enantiomer separations using this technique. [23][24][25][26][27][28][29][30][31][32][33][34] The difficulty of finding a suitable CS (being highly selective for the given racemic compounds) and the appropriate system of solvents, which might not suppress this selectivity and keep the capacity to elute the chiral solutes of interest, can presumably be the main reasons for the scarcity of applications in this field. The CSs employed until present were in general those directly used also in liquid chromatography or in other separation techniques.…”

Enantiomer Separation by Countercurrent Chromatography Using Cinchona Alkaloid Derivatives as Chiral Selectors

“…However, as mentioned before, there are not many examples described of enantiomer separations using this technique. [23][24][25][26][27][28][29][30][31][32][33][34] The difficulty of finding a suitable CS (being highly selective for the given racemic compounds) and the appropriate system of solvents, which might not suppress this selectivity and keep the capacity to elute the chiral solutes of interest, can presumably be the main reasons for the scarcity of applications in this field. The CSs employed until present were in general those directly used also in liquid chromatography or in other separation techniques.…”

Enantiomer Separation by Countercurrent Chromatography Using Cinchona Alkaloid Derivatives as Chiral Selectors

“…However, as mentioned before, there are not many examples described of enantiomer separations using this technique. [23][24][25][26][27][28][29][30][31][32][33][34] The difficulty of finding a suitable CS (being highly selective for the given racemic compounds) and the appropriate system of solvents, which might not suppress this selectivity and keep the capacity to elute the chiral solutes of interest, can presumably be the main reasons for the scarcity of applications in this field. The CSs employed until present were in general those directly used also in liquid chromatography or in other separation techniques.…”