Chiral Metal–DNA Four‐Arm Junctions and Metalated Nanotubular Structures

Yang, Hua; Altvater, Florian; Bruijn, A. Dowine de; McLaughlin, Christopher K.; Lo, Pik Kwan; Sleiman, Hanadi F.

doi:10.1002/ange.201007403

Cited by 34 publications

(15 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…134−140 For example, Sleiman and coworkers used a DNA-templated method to form a chiral (righthanded) metal−DNA junction, which contains a single copper-(I)−bisphenanthroline unit at its central point and four singlestranded DNA arms of different sequences (Figure 7A). 139 The copper-binding ligand diphenylphenanthroline (dpp) was chemically synthesized in the middle of two DNA strands. The two strands were then brought together by a linker DNA to achieve close proximity of the two dpp ligands.…”

Section: Other Strategies For the Construction Of Dna Nanostructuresmentioning

confidence: 99%

DNA Nanotechnology-Enabled Drug Delivery Systems

et al. 2018

View full text Add to dashboard Cite

Over the past decade, we have seen rapid advances in applying nanotechnology in biomedical areas including bioimaging, biodetection, and drug delivery. As an emerging field, DNA nanotechnology offers simple yet powerful design techniques for self-assembly of nanostructures with unique advantages and high potential in enhancing drug targeting and reducing drug toxicity. Various sequence programming and optimization approaches have been developed to design DNA nanostructures with precisely engineered, controllable size, shape, surface chemistry, and function. Potent anticancer drug molecules, including Doxorubicin and CpG oligonucleotides, have been successfully loaded on DNA nanostructures to increase their cell uptake efficiency. These advances have implicated the bright future of DNA nanotechnology-enabled nanomedicine. In this review, we begin with the origin of DNA nanotechnology, followed by summarizing state-of-the-art strategies for the construction of DNA nanostructures and drug payloads delivered by DNA nanovehicles. Further, we discuss the cellular fates of DNA nanostructures as well as challenges and opportunities for DNA nanostructure-based drug delivery.

show abstract

Section: Other Strategies For the Construction Of Dna Nanostructuresmentioning

confidence: 99%

DNA Nanotechnology-Enabled Drug Delivery Systems

et al. 2018

View full text Add to dashboard Cite

show abstract

“…Taking advantages of synthetic molecules as rigid junctions, this can reduce the amount of DNA strands needed for the structural definition as compared to the previous two methods. For example, Sleiman's group have successfully developed DNA-conjugated m-terphenyl-based organic vertices for modular construction of cyclic polygons, a library of DNA polyhedral structures and nanotubes with good control over their geometry [32], dimension [33], and flexibility [34]. Besides the organic insertions, other important self-assembly strategies take advantages of transition metal-, ligand-, lipidand block copolymer-based environments [35][36][37].…”

Section: Dna Nanotechnologymentioning

confidence: 99%

Multifunctional DNA Nanomaterials for Biomedical Applications

Tam

2015

Journal of Nanomaterials

Self Cite

View full text Add to dashboard Cite

The rapidly emerging DNA nanotechnology began with pioneer Seeman’s hypothesis that DNA not only can carry genetic information but also can be used as molecular organizer to create well-designed and controllable nanomaterials for applications in materials science, nanotechnology, and biology. DNA-based self-assembly represents a versatile system for nanoscale construction due to the well-characterized conformation of DNA and its predictability in the formation of base pairs. The structural features of nucleic acids form the basis of constructing a wide variety of DNA nanoarchitectures with well-defined shapes and sizes, in addition to controllable permeability and flexibility. More importantly, self-assembled DNA nanostructures can be easily functionalized to construct artificial functional systems with nanometer scale precision for multipurposes. Apparently scientists envision artificial DNA-based nanostructures as tool for drug loading andin vivotargeted delivery because of their abilities in selective encapsulation and stimuli-triggered release of cargo. Herein, we summarize the strategies of creating multidimensional self-assembled DNA nanoarchitectures and review studies investigating their stability, toxicity, delivery efficiency, loading, and control release of cargos in addition to their site-specific targeting and delivery of drug or cargo molecules to cellular systems.

show abstract

“…Copyright 2010 Macmillan Publishers Ltd) (j) Metal–DNA nanotubes formed from triangular rungs containing copper‐stabilized chiral junctions. (Reprinted with permission from Ref 130. Copyright 2011 John Wiley and Sons) (k) DNA nanotubes built upon a template strand produced by rolling circle amplification (RCA nanotubes).…”

Section: Dna Nanotechnologymentioning

confidence: 99%

“…The modular approach also gave access to metal–DNA nanotubes. In this work, chiral metal–DNA junctions composed of a copper(I)‐bisphenanthroline central unit and four single‐stranded DNA arms were used as the vertices of triangular rungs joined into nanotubes with linking strands 130. Another modification of the original construct was made to produce a DNA‐economic approach yielding more robust nanotubes that are resistant to nuclease degradation.…”

Section: Dna Nanotechnologymentioning

confidence: 99%

Long‐range assembly of DNA into nanofibers and highly ordered networks

Carneiro

Avakyan

Sleiman

2013

WIREs Nanomed Nanobiotechnol

Self Cite

View full text Add to dashboard Cite

Long-range assembly of DNA currently comprises both top-down and bottom-up methods. The top-down techniques consist of physical alignment of DNA and lithographic patterning to organize DNA on surfaces. The bottom-up approaches include lipid-and polymer-DNA co-assembly, the self-assembly of DNA amphiphiles, and the remarkably specific and versatile methods of DNA nanotechnology. DNA-based materials possess unprecedented molecular control and may offer innovative solutions in the fields of nanotechnology, sensing, nanomedicine, as well as optical and electronic devices. To realize the potential of these materials, a number of hurdles must be addressed. Bridging the gap between top-down fabrication and bottom-up assembly is of critical importance to the successful development of functional DNA-based technology. A profound understanding of both regimes is necessary to achieve this goal.

show abstract

Chiral Metal–DNA Four‐Arm Junctions and Metalated Nanotubular Structures

Cited by 34 publications

References 48 publications

DNA Nanotechnology-Enabled Drug Delivery Systems

DNA Nanotechnology-Enabled Drug Delivery Systems

Multifunctional DNA Nanomaterials for Biomedical Applications

Long‐range assembly of DNA into nanofibers and highly ordered networks

Contact Info

Product

Resources

About